Supplementary Data from Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism

Abstract

Supplemental Tables Supplemental Figures Supplemental Methods

Authors 15

1. Marije B. Overdijk

   Genmab (Netherlands)

   Affiliation as printed

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

2. Kristin Strumane

   Genmab (Netherlands)

   Affiliation as printed

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

3. Frank J M Beurskens

   Genmab (Netherlands)

   Affiliation as printed

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

4. Antonio Ortiz Buijsse

   Genmab (Netherlands)

   Affiliation as printed

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

5. Claudine Vermot‐Desroches
   Affiliation as printed

   iDD biotech, Lyon, France

6. Boris S. Vuillermoz
   Affiliation as printed

   iDD biotech, Lyon, France

7. Thessa Kroes

   Genmab (Netherlands) · The University of Adelaide

   Affiliation as printed

   Current affiliation: Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, Australia

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

8. Bart de Jong

   Genmab (Netherlands)

   Affiliation as printed

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

9. Naomi Hoevenaars

   Genmab (Netherlands)

   Affiliation as printed

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

10. Richard G. Hibbert

    Genmab (Netherlands)

    Affiliation as printed

    Genmab, Utrecht,

    The Netherlands, Copenhagen, Denmark, Princeton, USA

11. Ulf Forssmann

    Genmab (Netherlands)

    Affiliation as printed

    Genmab, Utrecht,

    The Netherlands, Copenhagen, Denmark, Princeton, USA

12. Janine Schuurman

    Genmab (Netherlands)

    Affiliation as printed

    Genmab, Utrecht,

    The Netherlands, Copenhagen, Denmark, Princeton, USA

13. Paul W.H.I. Parren Aachen

    Leiden University Medical Center · Genmab (Netherlands) · Lava Therapeutics (Netherlands)

    Affiliation as printed

    Current affiliation: Lava Therapeutics, Utrecht, The Netherlands

    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center; Leiden, The Netherlands

    Genmab, Utrecht,

    The Netherlands, Copenhagen, Denmark, Princeton, USA

14. Rob N. de Jong

    Genmab (Netherlands) · Champions Oncology (United States) · Crown Bioscience (China) · Nanjing University

    Affiliation as printed

    CrownBio, Beijing, China

    Nanjing Biomedical Research Institute of Nanjing University (BRI) or NU/NU (Vital River Laboratories Research Models and Services, Beijing, China)

    athymic nude (Beijing AK Bio-Technology Co. Ltd. or

    1010, CTG-0775, CTG-1234, CTG-0147, Athymic Nude-Foxn1 nu (Envigo, US

    Champions Oncology

    Genmab, Uppsalalaan 15, 3584CT, Utrecht, The Netherlands;

    NOD-SCID (Envigo, US or Jackson Laboratory, US) NSG (Envigo, US or Jackson Laboratory, US) for CR5089 CrownBio, San Diego, US

    NOD-SCID NSG for LU11714 CrownBio, San Diego, US

15. Esther C.W. Breij

    Genmab (Netherlands)

    Affiliation as printed

    Genmab, Utrecht,

    The Netherlands, Copenhagen, Denmark, Princeton, USA