High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

• Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery

  2023 Pharmaceuticals article Medicine Ocular Oncology and Treatments Open access

  16

  citations
• FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma

  2023 Cancers article Medicine Ocular Oncology and Treatments Open access

  16

  citations
• Supplementary Data from Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism

  2023 supplementary-materials Biochemistry, Genetics and Molecular Biology Cell death mechanisms and regulation Open access

  0

  citations
• Supplementary Data from Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism

  2023 supplementary-materials Biochemistry, Genetics and Molecular Biology Cell death mechanisms and regulation Open access

  0

  citations
• Preclinical Evaluation of Trabectedin in Combination With Targeted Inhibitors for Treatment of Metastatic Uveal Melanoma

  2022 Investigative Ophthalmology & Visual Science article Medicine Ocular Oncology and Treatments Open access

  6

  citations
• A 3D Perfusable Platform for In Vitro Culture of Patient Derived Xenografts

  2022 Advanced Healthcare Materials article Engineering 3D Printing in Biomedical Research Open access

  10

  citations
• Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

  2022 Nature Communications article Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics Open access cited by 4 patents

  27

  citations
• Immune cell infiltration pattern in non-small cell lung cancer PDX models is a model immanent feature and correlates with a distinct molecular and phenotypic make-up

  2022 Journal for ImmunoTherapy of Cancer article Medicine Cancer Immunotherapy and Biomarkers Open access

  14

  citations
• Predicting patient response with models trained on cell lines and patient-derived xenografts by nonlinear transfer learning

  2021 Proceedings of the National Academy of Sciences article Computer Science Computational Drug Discovery Methods Open access

  42

  citations
• Combi-Seq: Multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

  2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics Open access

  4

  citations
• Identification of high‐dimensional omics‐derived predictors for tumor growth dynamics using machine learning and pharmacometric modeling

  2021 CPT Pharmacometrics & Systems Pharmacology article Mathematics Mathematical Biology Tumor Growth Open access

  5

  citations
• Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy

  2021 Scientific Reports article Biochemistry, Genetics and Molecular Biology Breast Cancer Treatment Studies Open access

  60

  citations
• Patient-derived tumour models for personalized therapeutics in urological cancers

  2020 Nature Reviews Urology review Medicine Prostate Cancer Treatment and Research

  34

  citations
• Π electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer

  2020 Biomaterials article Materials Science Nanoparticle-Based Drug Delivery Open access

  47

  citations
• Predicting clinical drug response from model systems by non-linear subspace-based transfer learning

  2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Computer Science Computational Drug Discovery Methods Open access

  9

  citations
• Stratification and prediction of drug synergy based on target functional similarity

  2020 npj Systems Biology and Applications article Computer Science Computational Drug Discovery Methods Open access

  60

  citations
• Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma

  2020 European Journal of Cancer article Medicine Ocular Oncology and Treatments Open access

  28

  citations

17 results