Supplementary Data from Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism

Abstract

Supplemental Tables Supplemental Figures Supplemental Methods

Authors 15

1. Marije B. Overdijk

   Genmab (Netherlands)

   Affiliation as printed

   Genmab , Utrecht , The Netherlands , Copenhagen , Denmark , Princeton , USA

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

2. Kristin Strumane

   Genmab (Netherlands)

   Affiliation as printed

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

3. Frank J M Beurskens

   Genmab (Netherlands)

   Affiliation as printed

   Beijing , China

   Genmab , Utrecht , The Netherlands , Copenhagen , Denmark , Princeton , USA

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

4. Antonio Ortiz Buijsse

   Genmab (Netherlands)

   Affiliation as printed

   Genmab , Utrecht , The Netherlands , Copenhagen , Denmark , Princeton , USA

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

5. Claudine Vermot‐Desroches
   Affiliation as printed

   iDD biotech , Lyon , France

   iDD biotech, Lyon, France

6. Boris S. Vuillermoz
   Affiliation as printed

   iDD biotech , Lyon , France

   iDD biotech, Lyon, France

7. Thessa Kroes

   Genmab (Netherlands) · The University of Adelaide

   Affiliation as printed

   Current affiliation: Robinson Research Institute and Adelaide Medical School , University of Adelaide , Adelaide , Australia

   Genmab , Utrecht , The Netherlands , Copenhagen , Denmark , Princeton , USA

   Current affiliation: Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, Australia

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

8. Bart de Jong

   Genmab (Netherlands)

   Affiliation as printed

   Genmab , Utrecht , The Netherlands , Copenhagen , Denmark , Princeton , USA

   NU / NU ( Vital River Laboratories Research Models and Services , Beijing , China

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

9. Naomi Hoevenaars

   Genmab (Netherlands)

   Affiliation as printed

   Genmab , Utrecht , The Netherlands , Copenhagen , Denmark , Princeton , USA

   Genmab, Utrecht,

   The Netherlands, Copenhagen, Denmark, Princeton, USA

10. Richard G. Hibbert

    Genmab (Netherlands)

    Affiliation as printed

    Genmab , Utrecht , The Netherlands , Copenhagen , Denmark , Princeton , USA

    Genmab, Utrecht,

    The Netherlands, Copenhagen, Denmark, Princeton, USA

11. Ulf Forssmann

    Genmab (Netherlands)

    Affiliation as printed

    Genmab , Utrecht , The Netherlands , Copenhagen , Denmark , Princeton , USA

    Genmab, Utrecht,

    The Netherlands, Copenhagen, Denmark, Princeton, USA

12. Janine Schuurman

    Genmab (Netherlands) · Jackson Laboratory

    Affiliation as printed

    Genmab , Utrecht , The Netherlands , Copenhagen , Denmark , Princeton , USA

    NOD-SCID (Envigo , US or Jackson Laboratory , US) NSG (Envigo , US

    Genmab, Utrecht,

    The Netherlands, Copenhagen, Denmark, Princeton, USA

13. Paul W.H.I. Parren Aachen

    Leiden University Medical Center · Genmab (Netherlands) · Lava Therapeutics (Netherlands)

    Affiliation as printed

    Current affiliation: Lava Therapeutics, Utrecht, The Netherlands

    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center; Leiden, The Netherlands

    Genmab, Utrecht,

    The Netherlands, Copenhagen, Denmark, Princeton, USA

14. Rob N. de Jong

    Genmab (Netherlands) · Jackson Laboratory · Champions Oncology (United States) · Crown Bioscience (China) · Nanjing University

    Affiliation as printed

    Genmab , Utrecht , The Netherlands , Copenhagen , Denmark , Princeton , USA

    or Jackson Laboratory , US

    CrownBio, Beijing, China

    Nanjing Biomedical Research Institute of Nanjing University (BRI) or NU/NU (Vital River Laboratories Research Models and Services, Beijing, China)

    athymic nude (Beijing AK Bio-Technology Co. Ltd. or

    1010, CTG-0775, CTG-1234, CTG-0147, Athymic Nude-Foxn1 nu (Envigo, US

    Champions Oncology

    Genmab, Uppsalalaan 15, 3584CT, Utrecht, The Netherlands;

    NOD-SCID (Envigo, US or Jackson Laboratory, US) NSG (Envigo, US or Jackson Laboratory, US) for CR5089 CrownBio, San Diego, US

    NOD-SCID NSG for LU11714 CrownBio, San Diego, US

15. Esther C.W. Breij

    Genmab (Netherlands)

    Affiliation as printed

    Genmab, Utrecht,

    The Netherlands, Copenhagen, Denmark, Princeton, USA