A

Understanding metric-related pitfalls in image analysis validation

Nature Methods, vol. 21, pp. 182–194

Authors 69

  1. Annika Reinke corresponding

    German Cancer Research Center · Heidelberg University

    Affiliation as printed

    Faculty of Mathematics and Computer Science, Heidelberg University, Heidelberg, Germany. a.reinke@dkfz-heidelberg.de

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany. a.reinke@dkfz-heidelberg.de

    German Cancer Research Center (DKFZ) Heidelberg, HI Helmholtz Imaging, Heidelberg, Germany. a.reinke@dkfz-heidelberg.de

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany

  2. Minu D. Tizabi corresponding

    German Cancer Research Center · National Center for Tumor Diseases

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany. m.tizabi@dkfz-heidelberg.de

    National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and University Medical Center Heidelberg, Heidelberg, Germany. m.tizabi@dkfz-heidelberg.de

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany

  3. German Cancer Research Center

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Heidelberg, Germany

  4. German Cancer Research Center

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany

  5. German Cancer Research Center · National Center for Tumor Diseases

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany

    National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and University Medical Center Heidelberg, Heidelberg, Germany

  6. German Cancer Research Center

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany

    German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Heidelberg, Germany

    German Cancer Research Center (DKFZ) Heidelberg, HI Applied Computer Vision Lab, Heidelberg, Germany

  7. German Cancer Research Center

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany

    German Cancer Research Center (DKFZ) Heidelberg, HI Helmholtz Imaging, Heidelberg, Germany

  8. King's College London · MRC Unit for Lifelong Health and Ageing · University College London

    Affiliation as printed

    MRC Unit for Lifelong Health and Ageing at UCL and Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK

    School of Biomedical Engineering and Imaging Science, King's College London, London, UK

  9. Consejo Nacional de Investigaciones Científicas y Técnicas · Universidad de Buenos Aires

    Affiliation as printed

    Instituto de Cálculo, CONICET - Universidad de Buenos Aires, Buenos Aires, Argentina

    Instituto de Cálculo, CONICET – Universidad de Buenos Aires, Buenos Aires, Argentina

  10. King's College London · University College London

    Affiliation as printed

    Centre for Medical Image Computing, University College London, London, UK

    School of Biomedical Engineering and Imaging Science, King's College London, London, UK

  11. Mila - Quebec Artificial Intelligence Institute · McGill University

    Affiliation as printed

    Centre for Intelligent Machines and MILA (Quebec Artificial Intelligence Institute), McGill University, Montréal, Quebec, Canada

  12. Indiana University Indianapolis · Indiana University School of Medicine · University of Pennsylvania

    Affiliation as printed

    Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, USA

    Division of Computational Pathology, Dept of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

  13. Holon Institute of Technology

    Affiliation as printed

    Department of Digital Medical Technologies, Holon Institute of Technology, Holon, Israel

    European Federation for Medical Informatics, Le Mont-sur-Lausanne, Switzerland

  14. Goethe University Frankfurt · German Cancer Research Center · Frankfurt Cancer Institute

    Affiliation as printed

    Frankfurt Cancer Insititute, Frankfurt am Main, Germany

    German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, a partnership between DKFZ and UCT Frankfurt-Marburg, Frankfurt am Main, Germany

    German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany

    Goethe University Frankfurt, Department of Informatics, Frankfurt am Main, Germany

    Goethe University Frankfurt, Department of Medicine, Frankfurt am Main, Germany

  15. King's College London

    Affiliation as printed

    School of Biomedical Engineering and Imaging Science, King's College London, London, UK

  16. IT University of Copenhagen

    Affiliation as printed

    Department of Computer Science, IT University of Copenhagen, Copenhagen, Denmark

  17. Leibniz Institute for Analytical Sciences - ISAS

    Affiliation as printed

    Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany

    Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V., Dortmund, Germany

  18. German Cancer Research Center

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany

  19. Broad Institute

    Affiliation as printed

    Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA

  20. National Cancer Institute

    Affiliation as printed

    Center for Biomedical Informatics and Information Technology, National Cancer Institute, Bethesda, MD, USA

  21. Consejo Nacional de Investigaciones Científicas y Técnicas · Universidad de Buenos Aires

    Affiliation as printed

    Instituto de Investigación en Ciencias de la Computación (ICC), CONICET-UBA, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

  22. Universitat Pompeu Fabra · The University of Adelaide

    Affiliation as printed

    Universitat Pompeu Fabra, Barcelona, Spain

    University of Adelaide, Adelaide, South Australia, Australia

  23. Radboud University Nijmegen · Radboud University Medical Center · Fraunhofer Institute for Digital Medicine · Radboud Institute for Health Sciences

    Affiliation as printed

    Fraunhofer MEVIS, Bremen, Germany

    Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands

  24. Imperial College London

    Affiliation as printed

    Department of Computing, Imperial College London, South Kensington Campus, London, UK

  25. German Cancer Research Center · Heidelberg University · National Center for Tumor Diseases

    Affiliation as printed

    Faculty of Mathematics and Computer Science, Heidelberg University, Heidelberg, Germany

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany

    National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and University Medical Center Heidelberg, Heidelberg, Germany

  26. University of Pennsylvania

    Affiliation as printed

    Department of Surgery, Perelman School of Medicine, Philadelphia, PA, USA

    General Robotics Automation Sensing and Perception Laboratory, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA

  27. University Health Network · University of Toronto · Princess Margaret Cancer Centre · Vector Institute

    Affiliation as printed

    Department of Computer Science, University of Toronto, Toronto, Ontario, Canada

    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

    Vector Institute for Artificial Intelligence, Toronto, Ontario, Canada

  28. Radboud University Medical Center

    Affiliation as printed

    Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands

  29. German Cancer Research Center

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Heidelberg, Germany

    German Cancer Research Center (DKFZ) Heidelberg, HI Applied Computer Vision Lab, Heidelberg, Germany

  30. Inserm · Laboratoire Traitement du Signal et de l'Image · Université Rennes 1 · Université de Rennes

    Affiliation as printed

    INSERM, Paris, France

    Laboratoire Traitement du Signal et de l'Image - UMR_S 1099, Université de Rennes 1, Rennes, France

    Laboratoire Traitement du Signal et de l'Image – UMR_S 1099, Université de Rennes 1, Rennes, France

  31. University of Pennsylvania

    Affiliation as printed

    Department of Radiology and Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA

  32. University of Potsdam · Max Delbrück Center

    Affiliation as printed

    Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Biomedical Image Analysis and HI Helmholtz Imaging, Berlin, Germany

    University of Potsdam, Digital Engineering Faculty, Potsdam, Germany

  33. Friedrich-Alexander-Universität Erlangen-Nürnberg · Imperial College London

    Affiliation as printed

    Department AIBE, Friedrich-Alexander-Universität (FAU), Erlangen-Nürnberg, Germany

    Department of Computing, Faculty of Engineering, Imperial College London, London, UK

  34. Institut de Chirurgie Guidée par l'Image

    Affiliation as printed

    IHU Strasbourg, Strasbourg, France

  35. Essen University Hospital · Stiftung Universitätsmedizin Essen

    Affiliation as printed

    Translational Image-guided Oncology (TIO), Institute for AI in Medicine (IKIM), University Medicine Essen, Essen, Germany

  36. Affiliation as printed

    Helmholtz AI, Oberschleißheim, Germany

  37. Lunit (South Korea)

    Affiliation as printed

    Lunit, Seoul, South Korea

  38. German Cancer Research Center

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Biostatistics, Heidelberg, Germany

  39. Masaryk University

    Affiliation as printed

    Centre for Biomedical Image Analysis and Faculty of Informatics, Masaryk University, Brno, Czech Republic

  40. European Molecular Biology Laboratory

    Affiliation as printed

    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

  41. Stony Brook University

    Affiliation as printed

    Department of Biomedical Informatics, Stony Brook University, Health Science Center, Stony Brook, NY, USA

  42. Vanderbilt University

    Affiliation as printed

    Electrical Engineering, Vanderbilt University, Nashville, TN, USA

  43. Radboud University Medical Center

    Affiliation as printed

    Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands

  44. Affiliation as printed

    Department of Surgery, University Health Network, Philadelphia, PA, USA

  45. Klaus Hermann Maier-Hein corresponding

    German Cancer Research Center · Heidelberg University · University Hospital Heidelberg

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Heidelberg, Germany

    Pattern Analysis and Learning Group, Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany

  46. University of Toronto · Sunnybrook Hospital · Sunnybrook Research Institute

    Affiliation as printed

    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada

  47. UNSW Sydney

    Affiliation as printed

    School of Computer Science and Engineering, University of New South Wales, UNSW Sydney, Kensington, New South Wales, Australia

  48. University of Zurich

    Affiliation as printed

    Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland

  49. Utrecht University · University Medical Center Utrecht

    Affiliation as printed

    Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, Utrecht, the Netherlands

  50. University of Geneva · HES-SO University of Applied Sciences and Arts Western Switzerland

    Affiliation as printed

    Information Systems Institute, University of Applied Sciences Western Switzerland (HES-SO), Sierre, Switzerland

    Medical Faculty, University of Geneva, Geneva, Switzerland

  51. Mila - Quebec Artificial Intelligence Institute

    Affiliation as printed

    MILA (Quebec Artificial Intelligence Institute), Montréal, Quebec, Canada

  52. University Medical Center Hamburg-Eppendorf

    Affiliation as printed

    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  53. German Cancer Research Center

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Heidelberg, Germany

  54. Allen Institute for Cell Science

    Affiliation as printed

    Allen Institute for Cell Science, Seattle, WA, USA

  55. University of Bern · University Hospital of Bern

    Affiliation as printed

    ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland

    Department of Radiation Oncology, University Hospital Bern, University of Bern, Bern, Switzerland

  56. Simula Metropolitan Center for Digital Engineering · UiT The Arctic University of Norway

    Affiliation as printed

    Simula Metropolitan Center for Digital Engineering, Oslo, Norway

    UiT The Arctic University of Norway, Tromsø, Norway

  57. Affiliation as printed

    NVIDIA GmbH, München, Germany

  58. Heidelberg University · University Hospital Heidelberg

    Affiliation as printed

    Faculty of Medicine, Heidelberg University Hospital, Heidelberg, Germany

    Institute for Computational Biomedicine, Heidelberg University, Heidelberg, Germany

  59. University of Amsterdam

    Affiliation as printed

    Informatics Institute, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands

  60. Google (United States)

    Affiliation as printed

    Google Health, Google, Palo Alto, CA, USA

  61. National Institutes of Health · National Institutes of Health Clinical Center

    Affiliation as printed

    National Institutes of Health Clinical Center, Bethesda, MD, USA

  62. TU Wien

    Affiliation as printed

    Institute of Information Systems Engineering, TU Wien, Vienna, Austria

  63. Oulu University Hospital · University of Oulu

    Affiliation as printed

    Neurocenter Oulu, Oulu University Hospital, Oulu, Finland

    Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland

  64. University of Edinburgh

    Affiliation as printed

    School of Engineering, The University of Edinburgh, Edinburgh, Scotland

  65. Leiden University Medical Center · KU Leuven

    Affiliation as printed

    Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands

    Department of Development and Regeneration and EPI-centre, KU Leuven, Leuven, Belgium

  66. Institut national de recherche en sciences et technologies du numérique · Centre Inria de Saclay

    Affiliation as printed

    Parietal project team, INRIA Saclay-Île de France, Palaiseau, France

  67. National Institute of Allergy and Infectious Diseases

    Affiliation as printed

    National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA

  68. Paul F. Jäger corresponding

    German Cancer Research Center

    Affiliation as printed

    German Cancer Research Center (DKFZ) Heidelberg, HI Helmholtz Imaging, Heidelberg, Germany. p.jaeger@dkfz-heidelberg.de

    German Cancer Research Center (DKFZ) Heidelberg, Interactive Machine Learning Group, Heidelberg, Germany. p.jaeger@dkfz-heidelberg.de

    German Cancer Research Center (DKFZ) Heidelberg, Interactive Machine Learning Group, Heidelberg, Germany

  69. Lena Maier‐Hein corresponding

    German Cancer Research Center · Heidelberg University · University Hospital Heidelberg · National Center for Tumor Diseases

    Affiliation as printed

    Faculty of Mathematics and Computer Science, Heidelberg University, Heidelberg, Germany. l.maier-hein@dkfz-heidelberg.de

    Faculty of Medicine, Heidelberg University Hospital, Heidelberg, Germany. l.maier-hein@dkfz-heidelberg.de

    German Cancer Research Center (DKFZ) Heidelberg, Division of Intelligent Medical Systems, Heidelberg, Germany. l.maier-hein@dkfz-heidelberg.de

    German Cancer Research Center (DKFZ) Heidelberg, HI Helmholtz Imaging, Heidelberg, Germany. l.maier-hein@dkfz-heidelberg.de

    National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and University Medical Center Heidelberg, Heidelberg, Germany. l.maier-hein@dkfz-heidelberg.de

    Faculty of Medicine, Heidelberg University Hospital, Heidelberg, Germany

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References 38