The mast cell: A Janus in kidney transplants

Frontiers in Immunology, vol. 14, pp. 1122409

Abstract

Mast cells (MCs) are innate immune cells with a versatile set of functionalities, enabling them to orchestrate immune responses in various ways. Aside from their known role in allergy, they also partake in both allograft tolerance and rejection through interaction with regulatory T cells, effector T cells, B cells and degranulation of cytokines and other mediators. MC mediators have both pro- and anti-inflammatory actions, but overall lean towards pro-fibrotic pathways. Paradoxically, they are also seen as having potential protective effects in tissue remodeling post-injury. This manuscript elaborates on current knowledge of the functional diversity of mast cells in kidney transplants, combining theory and practice into a MC model stipulating both protective and harmful capabilities in the kidney transplant setting.

Authors 12

1. G. van der Elst

   Erasmus MC · Erasmus University Rotterdam

   Affiliation as printed

   Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands

2. Hilal Varol

   Erasmus MC · Erasmus University Rotterdam

   Affiliation as printed

   Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands

3. Maud A.W. Hermans

   Erasmus MC · Erasmus University Rotterdam

   Affiliation as printed

   Department of Internal Medicine, Division of Allergy and Clinical Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands

4. Carla C. Baan

   Erasmus MC · Erasmus University Rotterdam

   Affiliation as printed

   Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands

5. J. P. Duong-van Huyen

   Assistance Publique – Hôpitaux de Paris · Hôpital Necker-Enfants Malades

   Affiliation as printed

   Department of Pathology, Necker Hospital, APHP, Paris, France

6. Dennis Alexander Hesselink

   Erasmus MC · Erasmus University Rotterdam

   Affiliation as printed

   Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands

7. Rafael Kramann Aachen Division of Nephrology and Clinical Immunology Institute of Experimental Medicine and Systems Biology

   RWTH Aachen University · Universitätsklinikum Aachen · Erasmus MC · Erasmus University Rotterdam

   Affiliation as printed

   Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands

   Division of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany

   Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany

8. Marion Rabant

   Assistance Publique – Hôpitaux de Paris · Hôpital Necker-Enfants Malades

   Affiliation as printed

   Department of Pathology, Necker Hospital, APHP, Paris, France

9. Marlies E. J. Reinders

   Erasmus MC · Erasmus University Rotterdam

   Affiliation as printed

   Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands

10. Jan H. von der Thüsen

    Erasmus MC · Erasmus University Rotterdam

    Affiliation as printed

    Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands

11. Thierry P. P. van den Bosch

    Erasmus MC · Erasmus University Rotterdam

    Affiliation as printed

    Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands

12. Marian C. Clahsen‐van Groningen corresponding Aachen Institute of Experimental Medicine and Systems Biology

    RWTH Aachen University · Erasmus MC · Erasmus University Rotterdam

    Affiliation as printed

    Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands

    Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany