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Activated regulatory T-cells, dysfunctional and senescent T-cells dominate the microenvironment of pancreatic cancer2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics
Shivan Sivakumar, Enas Abu‐Shah, David Ahern, Edward H. Arbe-Barnes, Nagina Mangal, Srikanth Reddy, +9 more
1citations -
Pseudotime dynamics of T cells in pancreatic ductal adenocarcinoma inform distinct functional states within the regulatory and cytotoxic T cells2023 iScience article Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics Open access
Ashwin Jainarayanan, Nithishwer Mouroug-Anand, Edward H. Arbe-Barnes, Adam J. Bush, Rachael J. M. Bashford-Rogers, Adam Enver Frampton, +5 more
12citations -
A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke2020 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Sphingolipid Metabolism and Signaling Open access
Alexandra Lucaciu, Sandra Trautmann, Nerea Ferreirós, Helmuth Steinmetz, Josef M. Pfeilschifter, Robert Brunkhorst, +3 more
41citations -
EGF-Receptor against Amphiregulin (AREG) Influences Costimulatory Molecules on Monocytes and T Cells and Modulates T-Cell Responses2023 Journal of Immunology Research article Immunology and Microbiology Immune Cell Function and Interaction Open access
Stephan Dreschers, Christopher Platen, Louise Oppermann, Andreas Ludwig, Aaron Babendreyer, Thorsten W Orlikowsky
9citations -
Therapeutic depletion of CCR8 + tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy2021 Journal for ImmunoTherapy of Cancer article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 26 patents
Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Elizabeth Allen, Eva Van Overmeire, +23 more
215citations -
Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment2024 Cancer Research article Medicine Myeloproliferative Neoplasms: Diagnosis and Treatment Open access
Dominik Schmidt, Cornelia Endres, Rouven Hoefflin, Geoffroy Andrieux, Melissa Zwick, Nikolaos Karantzelis, +23 more
23citations -
Identification of CD8+ T cell PRDM1 in high-risk human plaques and its regulatory role in murine lesion development2022 Cardiovascular Research article Immunology and Microbiology Atherosclerosis and Cardiovascular Diseases Open access
Han Young Jin, Chang Wei Lu, Jan Nagenborg, Marco Manca, Joël Karel, Rachel Cavill, +7 more
0citations -
Identification of CD8+ T cell PRDM1 in high-risk human plaques and its regulatory role in murine lesion development2022 Atherosclerosis article Immunology and Microbiology Atherosclerosis and Cardiovascular Diseases Open access
Han Young Jin, S.L. Maas, C. Lu, J. Nagenborg, Marco Manca, J.M.H. Karel, +9 more
0citations -
Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis2024 Nature Cardiovascular Research article Immunology and Microbiology Atherosclerosis and Cardiovascular Diseases Open access
Yvonne Döring, Emiel P. C. van der Vorst, Yi Yan, Carlos Neideck, Xavier Blanchet, Yvonne J. F. M. Jansen, +22 more
34citations -
Multimodal single-cell analysis uncovers transcription factor networks underlying T-cell aging2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics Open access
Mina Shaigan, Deepika Puri, Giulia Fornero, René Krüger, Mara Steiger, Hannes Klump, +3 more
0citations -
Multimodal single-cell profiling reveals crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients2026 npj Precision Oncology article Medicine Cholangiocarcinoma and Gallbladder Cancer Studies Open access
Lara Heij, Sikander Hayat, Konrad Reichel, Sidrah Maryam, Colm J. O’Rourke, Xiuxiang Tan, +27 more
3citations