Nup50 plays more than one instrument

Cell Cycle, vol. 21, pp. 1785–1794

Abstract

Nup50 is nuclear pore complex component localized to the nuclear side of the pore and in the nucleoplasm. It has been characterized as an auxiliary factor in nuclear transport reactions. Our recent work indicates that it interacts with and stimulates RCC1, the sole guanine nucleotide exchange factor for the GTPase Ran. Here, we discuss how this interaction might contribute to Nup50 function in nuclear transport but also its other functions like control of gene expression, cell cycle and DNA damage repair.

Authors 2

1. Guillaume Holzer corresponding Aachen Institute of Biochemistry and Molecular Cell Biology Medical School

   RWTH Aachen University

   Affiliation as printed

   Institute of Biochemistry and Molecular Cell Biology, Medical School, RWTH Aachen University, Aachen, Germany

2. Wolfram Antonin Aachen Institute of Biochemistry and Molecular Cell Biology Medical School

   RWTH Aachen University

   Affiliation as printed

   Institute of Biochemistry and Molecular Cell Biology, Medical School, RWTH Aachen University, Aachen, Germany