Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications
Angewandte Chemie, vol. 133, pp. 23880–23887
Abstract
Abstract Adhesive hydrogels have been developed for wound healing applications. However, their adhesive performance is impaired dramatically due to their high swelling on wet tissues. To tackle this challenge, we fabricated a new type of non‐swelling protein adhesive for underwater and in vivo applications. In this soft material, the electrostatic complexation between supercharged polypeptides with oppositely charged surfactants containing 3,4‐dihydroxylphenylalanine or azobenzene moieties plays an important role for the formation of ultra‐strong adhesive coacervates. Remarkably, the adhesion capability is superior to commercial cyanoacrylate when tested in ambient conditions. Moreover, the adhesion is stronger than other reported protein‐based adhesives in underwater environment. The ex vivo and in vivo experiments demonstrate the persistent adhesive performance and outstanding behaviors for wound sealing and healing.
Authors 10
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University of Groningen · Zernike Institute for Advanced Materials · Tsinghua University
Affiliation as printed
Department of Chemistry Tsinghua University Beijing 100084 China
Zernike Institute for Advanced Materials University of Groningen Nijenborgh 4 9747 AG Groningen The Netherlands
Department of Chemistry, Tsinghua University, Beijing, 100084 China
These authors contributed equally to this work
Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
These authors contributed equally to this work
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
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Yu Jerry Zhou Aachen
DWI – Leibniz Institute for Interactive Materials
Affiliation as printed
DWI—Leibniz Institute for Interactive Materials Forckenbeckstr. 50 52056 Aachen Germany
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University of Groningen · Zernike Institute for Advanced Materials
Affiliation as printed
Zernike Institute for Advanced Materials University of Groningen Nijenborgh 4 9747 AG Groningen The Netherlands
Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization
Affiliation as printed
State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
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Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization · Tsinghua University
Affiliation as printed
Department of Chemistry Tsinghua University Beijing 100084 China
State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
Department of Chemistry, Tsinghua University, Beijing, 100084 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
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Kai Liu corresponding
Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · State Key Laboratory of Rare Earth Resources Utilization · Tsinghua University
Affiliation as printed
Department of Chemistry Tsinghua University Beijing 100084 China
State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
Department of Chemistry, Tsinghua University, Beijing, 100084 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
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