Pressurized Natural Deep Eutectic Solvent Extraction of Galanthamine and Related Alkaloids from Narcissus pseudonarcissus
Planta Medica, vol. 88, pp. 814–825
Abstract
Abstract The isolation of a compound from a natural source involves many organic and mostly toxic solvents for extraction and purification. Natural deep eutectic solvents have been shown to be efficient options for the extraction of natural products. They have the advantage of being composed of abundantly available common primary metabolites, being nontoxic and environmentally safe solvents. The aim of this study was to develop a natural deep eutectic solvent-based extraction method for galanthamine, an important therapeutic agent for the treatment of Alzheimerʼs disease. This alkaloid can be produced by synthesis or by extraction from Narcissus bulbs. To develop an efficient extraction method, a number of different natural deep eutectic solvents was first tested for their solubilization capacity of galanthamine bromide salt. Promising results were obtained for ionic liquids, as well as some amphoteric and acidic natural deep eutectic solvents. In a two-cycle extraction process, the best solvents were tested for the extraction of galanthamine from bulbs. The ionic liquids produced poor yields, and the best results were obtained with some acid and sugar mixtures, among which malic acid-sucrose-water (1 : 1 : 5) proved to be the best, showing similar yields to that of the exhaustive Soxhlet extraction with methanol. Furthermore, the natural deep eutectic solvent was more selective for galanthamine.
Authors 5
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Institut Teknologi Sepuluh Nopember
Affiliation as printed
Institute Technology of Sepuluh Nopember, Chemical Engineering Department, Surabaya, Indonesia
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Affiliation as printed
Natural Products Laboratory, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands
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Leiden University · Kyung Hee University
Affiliation as printed
College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea
Natural Products Laboratory, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands
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King Abdullah University of Science and Technology
Affiliation as printed
King Abdullah University of Science and Technology (KAUST), Biology and Environmental Science and Engineering, Thuwal, Saudi Arabia
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Affiliation as printed
Natural Products Laboratory, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands
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