Cover Feature: Natural Product Diversification by One‐Step Biocatalysis using Human P450 3A4 (ChemCatChem 1/2022)

ChemCatChem, vol. 14

Abstract

The Cover Feature shows cytochrome P450 3A4 revealing its magic ability to diversify natural products such as nootkatone to many functionalised metabolites in one step, as illustrated by a grey butterfly transforming into coloured butterflies. In their Research Article, N. D. Fessner et al. explored the synthetic potential of promiscuous human liver P450 3A4 for the late-stage diversification of natural products to produce oxyfunctionalised compound libraries of pharmaceutical or olfactory interest. The isolation of 31 authentic human metabolites at a 100 mg-scale from the P450 3A4-catalysed biotransformation of six selected terpenes, alkaloids and steroids represented an unprecedented degree of diversification. This study extends the synthetic repertoire for efficient enzymatic natural product modification. More information can be found in the Research Article by N. D. Fessner et al.

Authors 7

1. Nico D. Fessner corresponding

   Graz University of Technology · Nawi Graz

   Affiliation as printed

   Institute of Molecular Biotechnology NAWI Graz Graz University of Technology Petersgasse 14 8010 Graz Austria

   Institute of Molecular Biotechnology, NAWI Graz, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria

2. Christopher Grimm

   University of Graz · Nawi Graz

   Affiliation as printed

   Institute of Chemistry NAWI Graz University of Graz Heinrichstraße 28 8010 Graz Austria

3. Matic Srdič
   Affiliation as printed

   Bisy GmbH Wuenschendorf 292 Hofstätten an der Raab 8200 Hofstaetten Austria

   SeSaM-Biotech GmbH Forckenbeckstraße 50 52074 Aachen Germany

4. Hansjörg Weber

   Graz University of Technology · Nawi Graz

   Affiliation as printed

   Institute of Organic Chemistry NAWI Graz Graz University of Technology Stremayrgasse 9 8010 Graz Austria

   Institute of Organic Chemistry, NAWI Graz, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria

5. Wolfgang Kroutil

   University of Graz · Nawi Graz

   Affiliation as printed

   Institute of Chemistry NAWI Graz University of Graz Heinrichstraße 28 8010 Graz Austria

6. Ulrich Schwaneberg Aachen Institute of Biotechnology

   RWTH Aachen University

   Affiliation as printed

   Institute of Biotechnology RWTH Aachen University Worringerweg 3 52074 Aachen Germany

   Institute of Biotechnology, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany

7. Anton Glieder

   Graz University of Technology · Nawi Graz

   Affiliation as printed

   Institute of Molecular Biotechnology NAWI Graz Graz University of Technology Petersgasse 14 8010 Graz Austria

   Institute of Molecular Biotechnology, NAWI Graz, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria