Regulatory T cell function in autoimmune disease

Journal of Translational Autoimmunity, vol. 4, pp. 100130

Abstract

Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function.

Authors 2

1. Anandhi Rajendiran Aachen Department of Pediatrics, Pediatric Rheumatology

   RWTH Aachen University

   Affiliation as printed

   RWTH Aachen University , Department of Pediatrics, Pediatric Rheumatology , Pauwelsstr 30 , 52074 , Aachen , Germany

2. Klaus Tenbrock corresponding Aachen Department of Pediatrics, Pediatric Rheumatology

   RWTH Aachen University

   Affiliation as printed

   RWTH Aachen University, Department of Pediatrics, Pediatric Rheumatology, Pauwelsstr 30, 52074, Aachen, Germany