A Versatile Compact Parahydrogen Membrane Reactor

ChemPhysChem, vol. 22, pp. 2526–2534

Abstract

Abstract We introduce a Spin Transfer Automated Reactor (STAR) that produces continuous parahydrogen induced polarization (PHIP), which is stable for hours to days. We use the PHIP variant called signal amplification by reversible exchange (SABRE), which is particularly well suited to produce continuous hyperpolarization. The STAR is operated in conjunction with benchtop (1.1 T) and high field (9.4 T) NMR magnets, highlighting the versatility of this system to operate with any NMR or MRI system. The STAR uses semipermeable membranes to efficiently deliver parahydrogen into solutions at nano to milli Tesla fields, which enables 1 H, 13 C, and 15 N hyperpolarization on a large range of substrates including drugs and metabolites. The unique features of the STAR are leveraged for important applications, including continuous hyperpolarization of metabolites, desirable for examining steady‐state metabolism in vivo, as well as for continuous RASER signals suitable for the investigation of new physics.

Authors 7

1. Patrick M. TomHon corresponding

   North Carolina State University

   Affiliation as printed

   Department of Chemistry North Carolina State University Raleigh NC, 27695 USA

   Department of Chemistry, North Carolina State University, Raleigh, NC, 27695 USA

   These authors contributed equally

2. Suyong Han

   North Carolina State University

   Affiliation as printed

   Department of Chemical and Biomolecular Engineering North Carolina State University Raleigh NC, 27606 USA

   Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27606 USA

   These authors contributed equally

3. Sören Lehmkuhl

   North Carolina State University

   Affiliation as printed

   Department of Chemistry North Carolina State University Raleigh NC, 27695 USA

   Department of Chemistry, North Carolina State University, Raleigh, NC, 27695 USA

4. Stephan Appelt Aachen Institut für Technische Chemie und Makromolekulare Chemie (ITMC)

   Forschungszentrum Jülich · RWTH Aachen University

   Affiliation as printed

   Central Institute for Engineering, Electronics and Analytics – Electronic Systems (ZEA-2) Forschungszentrum Jülich GmbH 52425 Jülich Germany

   Institut für Technische Chemie und Makromolekulare Chemie (ITMC) RWTH Aachen University 52056 Aachen Germany

5. Eduard Y. Chekmenev

   Russian Academy of Sciences · Wayne State University · The Barbara Ann Karmanos Cancer Institute

   Affiliation as printed

   Department of Chemistry Integrative Biosciences (Ibio) Karmanos Cancer Institute (KCI) Wayne State University Detroit MI, 48202 USA

   Russian Academy of Sciences Leninskiy Prospekt 14 119991 Moscow Russia

   Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI, 48202 USA

   Russian Academy of Sciences, Leninskiy Prospekt 14, 119991 Moscow, Russia

6. Milad Abolhasani

   North Carolina State University

   Affiliation as printed

   Department of Chemical and Biomolecular Engineering North Carolina State University Raleigh NC, 27606 USA

   Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27606 USA

7. Thomas Theis corresponding

   University of North Carolina at Chapel Hill · North Carolina State University

   Affiliation as printed

   Department of Chemistry North Carolina State University Raleigh NC, 27695 USA

   Department of Physics North Carolina State University Raleigh NC, 27695 USA

   Joint Department of Biomedical Engineering University of North Carolina, Chapel Hill and North Carolina State University Chapel Hill and Raleigh NC, 27606 USA

   Department of Chemistry, North Carolina State University, Raleigh, NC, 27695 USA

   Department of Physics, North Carolina State University, Raleigh, NC, 27695 USA

   Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill and North Carolina State University, Chapel Hill and Raleigh, NC, 27606 USA