Toward Ultra‐High‐Quality‐Factor Wireless Masing Magnetic Resonance Sensing
Angewandte Chemie International Edition, vol. 63, pp. e202406551
Abstract
Abstract It has recently been shown that a bolus of hyperpolarized nuclear spins can yield stimulated emission signals similar in nature to maser signals, potentially enabling new ways of sensing hyperpolarized contrast media, including most notably [1‐ 13 C]pyruvate that is under evaluation in over 50 clinical trials for metabolic imaging of cancer. The stimulated NMR signal emissions lasting for minutes do not require radio‐frequency excitation, offering unprecedented advantages compared to conventional MR sensing. However, creating nuclear spin maser emission is challenging in practice due to stringent fundamental requirements, making practical in vivo applications hardly possible using conventional passive MR detectors. Here, we demonstrate the utility of a wireless NMR maser detector, the quality factor of which was enhanced 22‐fold (to 1,670) via parametric pumping. This active‐feedback technique breaks the intrinsic fundamental limit of NMR detector circuit quality factor. We show the use of parametric pumping to reduce the threshold requirement for inducing nuclear spin masing at 300 MHz resonance frequency in a preclinical MRI scanner. Indeed, stimulated emission from hyperpolarized protons was obtained under highly unfavorable conditions of low magnetic field homogeneity ( T 2 * of 3 ms). Greater gains of the quality factor of the MR detector (up to 1 million) were also demonstrated.
Authors 12
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Wayne State University · The Barbara Ann Karmanos Cancer Institute
Affiliation as printed
Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI) Wayne State University Detroit, Michigan 48202 United States
Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI) Wayne State University Detroit, Michigan 48202 United States
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Wayne State University · The Barbara Ann Karmanos Cancer Institute
Affiliation as printed
Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI) Wayne State University Detroit, Michigan 48202 United States
Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI) Wayne State University Detroit, Michigan 48202 United States
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Karlsruhe Institute of Technology
Affiliation as printed
Institute of Microstructure Technology Karlsruhe Institute of Technology 76344 Eggenstein-Leopoldshafen, Karlsruhe Germany
Institute of Microstructure Technology Karlsruhe Institute of Technology 76344 Eggenstein-Leopoldshafen, Karlsruhe Germany
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North Carolina State University
Affiliation as printed
Department of Chemistry North Carolina State University Raleigh, North Carolina 27695-8204 United States
Department of Chemistry North Carolina State University Raleigh, North Carolina 27695-8204 United States
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University of Freiburg · German Cancer Research Center · University Medical Center Freiburg · Deutsches Konsortium für Translationale Krebsforschung
Affiliation as printed
Division of Medical Physics, Department of Radiology, Medical Center, Faculty of Medicine University of Freiburg Killianstr. 5a Freiburg 79106 Germany
German Cancer Consortium (DKTK), Partner site Freiburg and German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280 Heidelberg 69120 Germany
Division of Medical Physics, Department of Radiology, Medical Center, Faculty of Medicine University of Freiburg Killianstr. 5a Freiburg 79106 Germany
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University of Freiburg · German Cancer Research Center · Wayne State University · University Medical Center Freiburg · The Barbara Ann Karmanos Cancer Institute · Deutsches Konsortium für Translationale Krebsforschung
Affiliation as printed
Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI) Wayne State University Detroit, Michigan 48202 United States
Division of Medical Physics, Department of Radiology, Medical Center, Faculty of Medicine University of Freiburg Killianstr. 5a Freiburg 79106 Germany
German Cancer Consortium (DKTK), Partner site Freiburg and German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280 Heidelberg 69120 Germany
Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI) Wayne State University Detroit, Michigan 48202 United States
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Karlsruhe Institute of Technology
Affiliation as printed
Institute of Microstructure Technology Karlsruhe Institute of Technology 76344 Eggenstein-Leopoldshafen, Karlsruhe Germany
Institute of Microstructure Technology Karlsruhe Institute of Technology 76344 Eggenstein-Leopoldshafen, Karlsruhe Germany
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Harvard University · Massachusetts General Hospital · Athinoula A. Martinos Center for Biomedical Imaging
Affiliation as printed
Department of Physics Harvard University Cambridge, Massachusetts 02138 United States
Massachusetts General Hospital A. A. Martinos Center for Biomedical Imaging Boston, Massachusetts 02129 United States
Massachusetts General Hospital A. A. Martinos Center for Biomedical Imaging Boston, Massachusetts 02129 United States
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Forschungszentrum Jülich · RWTH Aachen University
Affiliation as printed
Central Institute for Engineering, Electronics and Analytics—Electronic Systems (ZEA-2) Forschungszentrum Jülich GmbH D-52425 Jülich Germany
Institute of Technical and Macromolecular Chemistry RWTH Aachen University 52056 Aachen Germany
Institute of Technical and Macromolecular Chemistry RWTH Aachen University 52056 Aachen Germany
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North Carolina State University
Affiliation as printed
Department of Chemistry North Carolina State University Raleigh, North Carolina 27695-8204 United States
Department of Chemistry North Carolina State University Raleigh, North Carolina 27695-8204 United States
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Affiliation as printed
Department of Radiology Michigan State University East Lansing, Michigan 48824 United States
Department of Radiology Michigan State University East Lansing, Michigan 48824 United States
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Eduard Y. Chekmenev corresponding
Wayne State University · The Barbara Ann Karmanos Cancer Institute
Affiliation as printed
Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI) Wayne State University Detroit, Michigan 48202 United States
Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI) Wayne State University Detroit, Michigan 48202 United States
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