Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice
Frontiers in Pharmacology, vol. 12, pp. 693453
Abstract
Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-generation sequencing (NGS) technologies are emerging as a more comprehensive and time- and cost-effective approach in PGx. This review presents the main considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both the advantages and the challenges of implementing NGS-based tests in PGx. Moreover, the limitations of each NGS platform are revealed, and the solutions for setting up and management of these technologies in clinical practice are addressed.
Authors 5
-
Medical University of Białystok
Affiliation as printed
Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
Department of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, Bialystok, Poland
-
Leiden University Medical Center
Affiliation as printed
Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands
Leiden Network of Personalized Therapeutics, Leiden, Netherlands
-
Medical University of Białystok
Affiliation as printed
Department of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, Bialystok, Poland
-
Medical University of Białystok
Affiliation as printed
Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
-
Leiden University Medical Center
Affiliation as printed
Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands
Leiden Network of Personalized Therapeutics, Leiden, Netherlands
Cited by 65 stored of 65
No patents citing this paper on Lens.org (checked 2026-10-11).