A hierarchical dynamic model used for investigating feed efficiency and its relationship with hepatic gene expression in APOE*3‐Leiden.CETP mice
Physiological Reports, vol. 9, pp. e14832
Abstract
BACKGROUND: Feed efficiency (FE) is an important trait for livestock and humans. While the livestock industry focuses on increasing FE, in the current obesogenic society it is more of interest to decrease FE. Hence, understanding mechanisms involved in the regulation of FE and particularly how it can be decreased would help tremendously in counteracting the obesity pandemic. However, it is difficult to accurately measure or calculate FE in humans. In this study, we aimed to address this challenge by developing a hierarchical dynamic model based on humanized mouse data. METHODS: We analyzed existing experimental data derived from 105 APOE*3-Leiden.CETP (E3L.CETP) mice fed a high-fat high-cholesterol (HFHC) diet for 1 (N = 20), 2 (N = 19), 3 (N = 20), and 6 (N = 46) month. We developed an ordinary differential equation (ODE) based model to estimate the FE based on the longitudinal data of body weight and food intake. Since the liver plays an important role in maintaining metabolic homeostasis, we evaluated associations between FE and hepatic gene expression levels. Depending on the feeding duration, we observed different relationships between FE and hepatic gene expression levels. RESULTS: After 1-month feeding of HFHC diet, we observed that FE was associated with vitamin A metabolism, arachidonic acid metabolism, and the PPAR signaling pathway. After 3- and 6-month feeding of HFHC diet, we observed that FE was associated most strongly with expression levels of Spink1 and H19, genes involved in cell proliferation and glucose metabolism, respectively. CONCLUSIONS: In conclusion, our analysis suggests that various biological processes such as vitamin A metabolism, hepatic response to inflammation, and cell proliferation associate with FE at different stages of diet-induced obesity.
Authors 5
-
Xiang Zhang corresponding
Utrecht University · Amsterdam University Medical Centers · University of Amsterdam · Wageningen University & Research
Affiliation as printed
Department of Experimental Vascular Medicine Amsterdam University Medical CenterUniversity of Amsterdam Amsterdam The Netherlands
Human and Animal Physiology Wageningen University Wageningen The Netherlands
Theoretical Biology and Bioinformatics Utrecht University Utrecht The Netherlands
Department of Experimental Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands
Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands
-
University Medical Center Groningen
Affiliation as printed
Department of Pediatrics University Medical Center Groningen Groningen The Netherlands
Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands
-
Yanan Wang Aachen Department of Medicine Division of Endocrinology Leiden University Medical Center Leiden The Netherlands Department of Medicine Division of Endocrinology, Leiden University Medical Center Einthoven Laboratory for Experimental Vascular Medicine
University Medical Center Groningen · Leiden University Medical Center
Affiliation as printed
Department of Medicine Division of Endocrinology Leiden University Medical Center Leiden The Netherlands
Department of Pediatrics University Medical Center Groningen Groningen The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden The Netherlands
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
-
Patrick C.N. Rensen Aachen Department of Medicine Division of Endocrinology Leiden University Medical Center Leiden The Netherlands Department of Medicine Division of Endocrinology, Leiden University Medical Center Einthoven Laboratory for Experimental Vascular Medicine
Leiden University Medical Center
Affiliation as printed
Department of Medicine Division of Endocrinology Leiden University Medical Center Leiden The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden The Netherlands
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
-
University Medical Center Groningen · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Department of Experimental Vascular Medicine Amsterdam University Medical CenterUniversity of Amsterdam Amsterdam The Netherlands
Department of Pediatrics University Medical Center Groningen Groningen The Netherlands
Department of Experimental Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands
Cited by 4 stored of 4
4 results
No patents citing this paper on Lens.org (checked 2026-10-11).