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January 01, 2020 article Open access Aachen paper

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Cancer Cell, vol. 37, pp. 21–36.e13

DOI: 10.1016/j.ccell.2019.12.001 Full text (OA) OpenAlex

Authors 49

  1. Jermaine Goveia

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  2. Kateřina Rohlenová

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  3. Federico Taverna

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  4. Lucas Treps

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  5. Lena‐Christin Conradi

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  6. Andreas Pircher

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  7. Vincent Geldhof

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  8. Laura P. M. H. de Rooij

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  9. Joanna Maria Kalucka

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  10. Liliana Sokol

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  11. Melissa García‐Caballero

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  12. Yingfeng Zheng

    Sun Yat-sen University · State Key Laboratory of Ophthalmology · Zhongshan Ophthalmic Center, Sun Yat-sen University

    Affiliation as printed

    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, China

  13. Junbin Qian

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Translational Genetics, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  14. Laure-Anne Marie Nicole Teuwen

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  15. Shawez Khan

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  16. Bram Boeckx

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Translational Genetics, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  17. Els Wauters

    Universitair Ziekenhuis Leuven

    Affiliation as printed

    Respiratory Oncology Unit (Respiratory Medicine) and Leuven Lung Cancer Group, University Hospitals Leuven, Leuven 3000, Belgium

  18. Herbert Decaluwé

    Universitair Ziekenhuis Leuven

    Affiliation as printed

    Respiratory Oncology Unit (Respiratory Medicine) and Leuven Lung Cancer Group, University Hospitals Leuven, Leuven 3000, Belgium; Department of Thoracic Surgery, University Hospitals Leuven, Leuven 3000, Belgium

    Department of Thoracic Surgery, University Hospitals Leuven, Leuven 3000, Belgium

    Respiratory Oncology Unit (Respiratory Medicine) and Leuven Lung Cancer Group, University Hospitals Leuven, Leuven 3000, Belgium

  19. Paul De Leyn

    Universitair Ziekenhuis Leuven

    Affiliation as printed

    Respiratory Oncology Unit (Respiratory Medicine) and Leuven Lung Cancer Group, University Hospitals Leuven, Leuven 3000, Belgium; Department of Thoracic Surgery, University Hospitals Leuven, Leuven 3000, Belgium

    Department of Thoracic Surgery, University Hospitals Leuven, Leuven 3000, Belgium

    Respiratory Oncology Unit (Respiratory Medicine) and Leuven Lung Cancer Group, University Hospitals Leuven, Leuven 3000, Belgium

  20. Johan Vansteenkiste

    Universitair Ziekenhuis Leuven

    Affiliation as printed

    Respiratory Oncology Unit (Respiratory Medicine) and Leuven Lung Cancer Group, University Hospitals Leuven, Leuven 3000, Belgium

  21. Birgit Weynand

    KU Leuven

    Affiliation as printed

    Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Leuven 3000, Belgium

  22. Xavier Sagaert

    KU Leuven

    Affiliation as printed

    Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Leuven 3000, Belgium

  23. Erik K. Verbeken

    KU Leuven

    Affiliation as printed

    Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Leuven 3000, Belgium

  24. Albert M. Wolthuis

    Universitair Ziekenhuis Leuven

    Affiliation as printed

    Department of Abdominal Surgery, University Hospitals Leuven, Leuven 3000, Belgium

  25. Baki Topal

    Universitair Ziekenhuis Leuven

    Affiliation as printed

    Department of Abdominal Surgery, University Hospitals Leuven, Leuven 3000, Belgium

  26. Wouter Everaerts

    Universitair Ziekenhuis Leuven · KU Leuven

    Affiliation as printed

    Laboratory for Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium; Department of Urology, University Hospitals Leuven, Leuven 3000, Belgium

    Department of Urology, University Hospitals Leuven, Leuven 3000, Belgium

    Laboratory for Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium

  27. Hanibal Bohnenberger

    Universitätsmedizin Göttingen · University of Göttingen

    Affiliation as printed

    Institute of Pathology, University Medical Center, Göttingen 37075, Germany

  28. Alexander Emmert

    Universitätsmedizin Göttingen · University of Göttingen

    Affiliation as printed

    Department of Thoracic and Cardiovascular Surgery, University Medical Center, Göttingen 37075, Germany

  29. Dena Panovska

    KU Leuven

    Affiliation as printed

    Laboratory for Precision Cancer Medicine, Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Leuven 3000, Belgium

  30. Frederik De Smet

    KU Leuven

    Affiliation as printed

    Laboratory for Precision Cancer Medicine, Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Leuven 3000, Belgium

  31. Frank J. T. Staal Aachen Department of Immunology and Blood Transfusion

    Leiden University Medical Center

    Affiliation as printed

    Department of Immunology and Blood Transfusion, Leiden University Medical Center, Leiden 2300 RC, the Netherlands

  32. Rene J. McLaughlin Aachen Department of Immunology and Blood Transfusion

    Leiden University Medical Center

    Affiliation as printed

    Department of Immunology and Blood Transfusion, Leiden University Medical Center, Leiden 2300 RC, the Netherlands

  33. Francis Impens

    Vlaams Instituut voor Biotechnologie · Ghent University · VIB-UGent Center for Medical Biotechnology

    Affiliation as printed

    VIB Proteomics Core and VIB Center for Medical Biotechnology, Ghent 9000, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent 9000, Belgium

    Department of Biomolecular Medicine, Ghent University, Ghent 9000, Belgium

    VIB Proteomics Core and VIB Center for Medical Biotechnology, Ghent 9000, Belgium

  34. Vincenzo Lagani

    Ilia State University

    Affiliation as printed

    Institute of Chemical Biology, Ilia State University, Tbilisi 0162, Georgia; Gnosis Data Analysis PC, Heraklion GR-700 13, Greece

    Gnosis Data Analysis PC, Heraklion GR-700 13, Greece

    Institute of Chemical Biology, Ilia State University, Tbilisi 0162, Georgia

  35. Stefan Vinckier

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  36. Massimiliano Mazzone

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Tumor Inflammation and Angiogenesis, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  37. Luc Schoonjans

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  38. Mieke A. Dewerchin

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  39. Guy Eelen

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  40. Tobias K. Karakach

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  41. Huanming Yang

    BGI Group (China) · China National GeneBank

    Affiliation as printed

    BGI-Shenzhen, Shenzhen 518083, China; China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China

    BGI-Shenzhen, Shenzhen 518083, China

    China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China

  42. Jian Wang

    BGI Group (China) · China National GeneBank

    Affiliation as printed

    BGI-Shenzhen, Shenzhen 518083, China; China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China

    BGI-Shenzhen, Shenzhen 518083, China

    China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China

  43. Lars Bolund

    BGI Group (China) · Aarhus University

    Affiliation as printed

    Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark; Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China

    Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark

    Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China

  44. Lin Lin

    BGI Group (China) · Aarhus University

    Affiliation as printed

    Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark; Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China

    Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark

    Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China

  45. Bernard Thienpont

    KU Leuven

    Affiliation as printed

    Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium

  46. Xuri Li corresponding

    Sun Yat-sen University · State Key Laboratory of Ophthalmology · Zhongshan Ophthalmic Center, Sun Yat-sen University

    Affiliation as printed

    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, China. Electronic address: lixr6@mail.sysu.edu.cn

    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, China

  47. Diether Lambrechts

    VIB-KU Leuven Center for Cancer Biology · KU Leuven

    Affiliation as printed

    Laboratory of Translational Genetics, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

  48. Yonglun Luo corresponding

    BGI Group (China) · Aarhus University · China National GeneBank

    Affiliation as printed

    BGI-Shenzhen, Shenzhen 518083, China; China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China; Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark; Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China. Electronic address: alun@biomed.au.dk

    BGI-Shenzhen, Shenzhen 518083, China

    China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China

    Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark

    Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China

  49. Peter Carmeliet corresponding

    Sun Yat-sen University · VIB-KU Leuven Center for Cancer Biology · State Key Laboratory of Ophthalmology · Zhongshan Ophthalmic Center, Sun Yat-sen University · KU Leuven

    Affiliation as printed

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, China. Electronic address: peter.carmeliet@kuleuven.vib.be

    Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, Leuven 3000, Belgium

    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, China

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References 69