Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b

• Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens

  2025 Cell Reports Medicine article Medicine Monoclonal and Polyclonal Antibodies Research Open access

  0

  citations
• Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation

  2025 PNAS Nexus article Immunology and Microbiology Complement system in diseases Open access

  1

  citations
• Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches

  2024 Seminars in Immunology article Immunology and Microbiology Complement system in diseases Open access

  18

  citations
• Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein

  2024 Proceedings of the National Academy of Sciences article Immunology and Microbiology Biomarkers in Disease Mechanisms Open access cited by 2 patents

  26

  citations
• Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation

  2024 The Journal of Immunology article Immunology and Microbiology Complement system in diseases Open access

  5

  citations
• Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators

  2024 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent

  11

  citations
• DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation

  2024 Journal of the American Chemical Society article Immunology and Microbiology Complement system in diseases Open access cited by 2 patents

  16

  citations
• Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein

  2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Biomarkers in Disease Mechanisms Open access cited by 2 patents

  3

  citations
• Selection and characterization of a peptide-based complement modulator targeting C1 of the innate immune system

  2024 RSC Chemical Biology article Immunology and Microbiology Complement system in diseases Open access

  2

  citations
• Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation

  2023 Proceedings of the National Academy of Sciences article Medicine Systemic Lupus Erythematosus Research Open access cited by 3 patents

  18

  citations
• DNA nanostructure-templated antibody complexes provide insights into the geometric requirements of human complement cascade activation

  2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Complement system in diseases Open access

  0

  citations
• Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

  2023 Nature Communications article Immunology and Microbiology Complement system in diseases Open access cited by 2 patents

  50

  citations
• Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

  2023 Nature Communications article Medicine Malaria Research and Control Open access

  22

  citations
• PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation

  2022 Proceedings of the National Academy of Sciences article Immunology and Microbiology Biomarkers in Disease Mechanisms Open access

  45

  citations
• Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

  2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Malaria Research and Control Open access

  3

  citations
• Avidity in antibody effector functions and biotherapeutic drug design

  2022 Nature Reviews Drug Discovery review Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 1 patent

  267

  citations
• At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity

  2022 The Journal of Immunology article Immunology and Microbiology Complement system in diseases Open access

  27

  citations
• C1q binding to surface-bound IgG is stabilized by C1r 2 s 2 proteases

  2021 Proceedings of the National Academy of Sciences article Immunology and Microbiology Complement system in diseases Open access cited by 1 patent

  62

  citations
• C1q binding to surface-bound IgG is stabilized by C1r 2 s 2 proteases

  2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Complement system in diseases Open access

  1

  citations

19 results