POLYMERIC MICELLES COMPRISING GLUCURONIDE-PRODRUGS
Espacenet
Family 77155733
Abstract
The invention relates to a polymeric micelle comprising a block copolymer comprising a polyethylene glycol (PEG) hydrophilic block and a hydrophobic block, and a compound according to formula (I) or formula (III) encapsulated within said polymeric micelle and to uses thereof.
Inventors 3
- Yang Mei Shi Aachen author as filed: Shi, Yang
- Twan Lammers Aachen author as filed: Lammers, Twan
- Josbert M. Metselaar Aachen author as filed: Metselaar, Josbert Maarten
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN RWTH Aachen University
Cited papers 7 in the database
Non-patent literature as cited (24)
- - CHEMICAL REVIEWS, vol. 71, no. 6, 1971
- - RIOS-DORIA, J.DURHAM, N.WETZEL, L.ROTHSTEIN, R.CHESEBROUGH, J.HOLOWECKYJ, N.ZHAO, W.LEOW, C. C.HOLLINGSWORTH, R.: "Doxil synergizes with cancer immunotherapies to enhance antitumor responses in syngeneic mouse models", NEOPLASIA, vol. 17, 2015, pages 661 - 670, XP002753467, DOI: 10.1016/j.neo.2015.08.004
- - ZHAO, X.YANG, K.ZHAO, R.JI, T.WANG, X.YANG, X.ZHANG, Y.CHENG, K.LIU, S.HAO, J.: "Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy", BIOMATERIALS, vol. 102, 2016, pages 187 - 197, XP029630728, DOI: 10.1016/j.biomaterials.2016.06.032
- - BOLLENBACK ET AL., THE SYNTHESIS OF ARYL-D-GLUCOPYRANOSIDURONIC ACIDS, 1954, pages 3310 - 3315
- - BOSCO ET AL., LEWIS-ACIDIC POLYOXOMETALATES AS REUSABLE CATALYSTS FOR THE SYNTHESIS OF GLUCURONIC ACID ESTERS UNDER MICROWAVE IRRADIATION, 2010, pages 1249 - 1252
- - BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 26, 2018, pages 5624 - 5630
- - MOLECULES, vol. 23, 2018, pages 2608 - 2020
- - DE GRAAF ET AL., BIOCHEM PHARMACOL, vol. 68, no. 11, 1 December 2004 (2004-12-01), pages 2273
- - DE GROOT ET AL., J ORG CHEM, vol. 66, no. 26, 28 December 2001 (2001-12-28), pages 8815 - 30
- - HOUBA ET AL., BR J CANCER, vol. 78, no. 12, December 1998 (1998-12-01), pages 1600 - 6
- - HOUBA ET AL., BR J CANCER, vol. 84, no. 4, February 2001 (2001-02-01), pages 550 - 7
- - LEENDERS ET AL., BIOORG MED CHEM, vol. 7, no. 8, August 1999 (1999-08-01), pages 1597 - 610
- - D. NERADOVIC ET AL., MACROMOLECULES, vol. 34, no. 22, 2001, pages 7589 - 7591
- - RUIZ-HERNANDEZ ET AL., POLYM CHEM, vol. 5, 7 March 2014 (2014-03-07), pages 1674 - 1681
- - SHI ET AL., BIOMACROMOLECULES, vol. 14, 2013, pages 1826 - 1837
- - TALLELI ET AL., BIOCONJUG CHEM, vol. 22, no. 12, 21 December 2011 (2011-12-21), pages 2519 - 30
- - TRANOY-OPALINSKI ET AL., ANTICANCER AGENTS MED CHEM, vol. 8, no. 6, August 2008 (2008-08-01), pages 618 - 37
- - GRAAF M D ET AL: "A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 68, no. 11, 1 December 2004 (2004-12-01), pages 2273 - 2281, XP004605771, ISSN: 0006-2952, DOI: 10.1016/J.BCP.2004.08.004
- - BONT DE D B A ET AL: "SYNTHESIS AND BIOLOGICAL ACTIVITY OF BETA-GLUCURONYL CARBAMATE-BASED PRODRUGS OF PACLITAXEL AS POTENTIAL CANDIDATES FOR ADEPT", BIOORGANIC, ELSEVIER, AMSTERDAM, NL, vol. 5, no. 2, 1 February 1997 (1997-02-01), pages 405 - 414, XP002047866, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(96)00249-0
- - LEENDERS RUBEN G.G. ET AL: "Novel anthracycline-spacer-[beta]-glucuronide, -[beta]-glucoside, and -[beta]-galactoside prodrugs for application in selective chemotherapy", BIOORGANIC, vol. 7, no. 8, 1 August 1999 (1999-08-01), AMSTERDAM, NL, pages 1597 - 1610, XP055858139, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(99)00095-4
- - RUIZ-HERNÁNDEZ EDUARDO ET AL: "PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses", POLYMER CHEMISTRY, vol. 5, no. 5, 1 January 2014 (2014-01-01), pages 1674 - 1681, XP055858135, ISSN: 1759-9954, Retrieved from the Internet <URL:https://pubs.rsc.org/en/content/articlepdf/2014/py/c3py01097j> DOI: 10.1039/C3PY01097J
- - M. TALELLI ET AL: "Synthesis and Characterization of Biodegradable and Thermosensitive Polymeric Micelles with Covalently Bound Doxorubicin-Glucuronide Prodrug via Click Chemistry", BIOCONJUGATE CHEMISTRY, vol. 22, no. 12, 21 December 2011 (2011-12-21), US, pages 2519 - 2530, XP055770371, ISSN: 1043-1802, DOI: 10.1021/bc2003499
- - LEENDERS R G G ET AL: "@b-Glucuronyl Carbamate Based Pro-moieties Designed for Prodrugs in ADEPT", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 36, no. 10, 6 March 1995 (1995-03-06), pages 1701 - 1704, XP004028569, ISSN: 0040-4039, DOI: 10.1016/0040-4039(95)00049-I
- - WANG BI ET AL: "Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 142, no. 28, 15 July 2020 (2020-07-15), pages 12133 - 12139, XP055857884, ISSN: 0002-7863, Retrieved from the Internet <URL:https://pubs.acs.org/doi/pdf/10.1021/jacs.0c01928> DOI: 10.1021/jacs.0c01928