NANOVESICLES FOR ENGINEERING IMMUNE CELLS
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Family 94823859
Abstract
The present invention concerns, among others, a nanovesicle comprising an aqueous core and a shell formed from a plurality of conjugates, each conjugate comprising a head portion, a tail portion and an intermediate portion in-between, wherein the head portion contains a first drug component, the tail portion contains a polymer component and optionally a second drug component and/or a targeting ligand, and the intermediate portion contains a cleavable linker, and wherein the head portion has a higher hydrophobicity than the tail portion.
Inventors 2
- Yang Mei Shi Aachen author as filed: Shi, Yang
- Bi, Wang
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE AACHEN, ABGEKÜRZT RWTH AACHEN, KÖRPERSCHAFT DES ÖFFENTLICHEN RECHTS RWTH Aachen University
Cited papers 2 in the database
Non-patent literature as cited (2)
- - WANG BI ET AL: "Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles", LANGMUIR, vol. 142, no. 28, 15 July 2020 (2020-07-15), pages 12133 - 12139, XP055857884, Retrieved from the Internet <URL:https://pubs.acs.org/doi/pdf/10.1021/jacs.0c01928> DOI: 10.1021/jacs.0c01928
- - WANG BI ET AL: "Targeting intracellular and extracellular receptors with nano-to-macroscale biomaterials to activate immune cells", JOURNAL OF CONTROLLED RELEASE, vol. 357, 1 May 2023 (2023-05-01), NL, pages 52 - 66, XP093279054, ISSN: 0168-3659, Retrieved from the Internet <URL:https://pdf.sciencedirectassets.com/271103/1-s2.0-S0168365923X00042/1-s2.0-S0168365923001955/main.pdf?hash=b823648e6dc54acdf6b52336baf8918630c7bf9114190ff9b40a5b8ce5ca1ed6&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0168365923001955&tid=spdf-aaad4c62-302a-4ede-a914-403> DOI: 10.1016/j.jconrel.2023.03.028