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Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes2020 Toxicological Sciences article Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access
Umber Saleem, Berend J. van Meer, Puspita Anggraini Katili, Nurul Ain Nasim Mohd Yusof, Ingra Mannhardt, Ana Krotenberg García, +16 more
74citations -
Aneugen Versus Clastogen Evaluation and Oxidative Stress-Related Mode-of-Action Assessment of Genotoxic Compounds Using the ToxTracker Reporter Assay2020 Toxicological Sciences article Biochemistry, Genetics and Molecular Biology Carcinogens and Genotoxicity Assessment
Inger Brandsma, Nynke Moelijker, Remco S. Derr, Giel Hendriks
22citations -
A systems approach reveals species differences in hepatic stress response capacity2023 Toxicological Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Giusy Russomanno, Rowena L. C. Sison-Young, Lucia A Livoti, Hannah Coghlan, Rosalind E. Jenkins, Steven J. Kunnen, +14 more
16citations -
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury2023 Toxicological Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Lukas S. Wijaya, Attila Gábor, Iris Pot, Luca van de Have, Julio Sáez-Rodríguez, James L. Stevens, +3 more
13citations -
Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds2021 Toxicological Sciences article Biochemistry, Genetics and Molecular Biology Estrogen and related hormone effects Open access
Britt Duijndam, Annabel Goudriaan, Tineke van den Hoorn, Wanda van der Stel, Sylvia E. Le Dévédec, Peter Bouwman, +2 more
11citations -
Systematic comparison of temporal hepatotoxicant-induced gene network responses across 3 liver test systems2026 Toxicological Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Tamara Y Danilyuk, Marou Schouten, Elsje J Burgers, Barira Islam, Joost B. Beltman, Peter Bouwman, +2 more
0citations -
Analytical choices drive toxicogenomic potency estimates: a systematic evaluation of transcriptomic points of departure2026 Toxicological Sciences article Biochemistry, Genetics and Molecular Biology Carcinogens and Genotoxicity Assessment Open access
Imke B. Bruns, Dayna R. Schultz, Emmanuel Demuynck, Friedel Dewulf, Ioannis Theologidis, Steven J. Kunnen, +12 more
0citations -
Towards Bayesian-based quantitative adverse outcome pathways using in vitro data from open literature and continuous variables: a case example for liver fibrosis2026 Toxicological Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Robin Durník, Tereza Juchelková, Helge Hecht, Levi M. T. Winkelman, Joost B. Beltman, Xavier Coumoul, +4 more
0citations
12 results