-
Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations2021 Journal of Pharmacokinetics and Pharmacodynamics article Neuroscience Barrier Structure and Function Studies Open access
Mohammed A. A. Saleh, Chi Fong Loo, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
43citations -
Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM12020 Journal of Pharmacokinetics and Pharmacodynamics article Medicine HER2/EGFR in Cancer Research Open access
Alison M. Betts, Tracey H. Clark, Paul Jasper, John E. Tolsma, Piet H. van der Graaf, Edmund I. Graziani, +4 more
25citations -
A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis2022 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Sepsis Diagnosis and Treatment Open access
Feiyan Liu, Linda B. S. Aulin, Sebastiaan S. A. Kossen, Julius Cathalina, Marlotte Bremmer, Amanda C. Foks, +3 more
11citations -
Generation of realistic virtual adult populations using a model-based copula approach2024 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Pharmaceutical studies and practices Open access
Yuchen Guo, Tingjie Guo, Catherijne A. J. Knibbe, Laura B. Zwep, J. G. Coen van Hasselt
8citations -
Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?2025 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Berfin Gülave, Ariel Lesmana, Elizabeth C. M. de Lange, J. G. Coen van Hasselt
4citations -
Semi-mechanistic modeling of resistance development to β-lactam and β-lactamase-inhibitor combinations2023 Journal of Pharmacokinetics and Pharmacodynamics article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Sebastian Tommi Tandar, Linda B. S. Aulin, Eva M. J. Leemkuil, Apostolos Liakopoulos, J. G. Coen van Hasselt
3citations -
Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?2025 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Daan W. van Valkengoed, Makoto Hirasawa, Vivi Rottschäfer, Elizabeth C. M. de Lange
3citations -
Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling2020 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Growth Hormone and Insulin-like Growth Factors Open access
Michiel Joost van Esdonk, Jacobus Burggraaf, Marion Dehez, Piet H. van der Graaf, Jasper Stevens
3citations -
Mechanism-based modeling of the effect of a novel inhibitor of vascular adhesion protein-1 on albuminuria and renal function markers in patients with diabetic kidney disease2020 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Chronic Kidney Disease and Diabetes Open access
Sven Hoefman, Nelleke Snelder, Alberto García-Hernández, Hartmut Onkels, Tobias E. Larsson, Kirsten Riber Bergmann
3citations -
Simulation-based assessment of the P-glycoprotein expression-activity relationship shows a drug and system dependency2026 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Daan W. van Valkengoed, Vivi Rottschäfer, Elizabeth C. M. de Lange
1citations -
Assessing the impact of bacterial heterogeneity on bacteriophage population dynamics2026 Journal of Pharmacokinetics and Pharmacodynamics article Environmental Science Bacteriophages and microbial interactions Open access
Massinissa Beldjenna, J Y Guedj, J. G. Coen van Hasselt, Tingjie Guo
1citations -
Population pharmacokinetics and pharmacodynamics of a novel vascular adhesion protein-1 inhibitor using a multiple-target mediated drug disposition model2020 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Pharmaceutical studies and practices Open access
Nelleke Snelder, Sven Hoefman, Alberto García-Hernández, Hartmut Onkels, Tobias E. Larsson, Kirsten Riber Bergmann
1citations -
Aggregate data modelling: A fast implementation for fitting pharmacometrics models to summary-level data in R2025 Journal of Pharmacokinetics and Pharmacodynamics article Mathematics Statistical Methods in Clinical Trials Open access
Hidde van de Beek, Pyry A. J. Välitalo, J. G. Coen van Hasselt, Laura B. Zwep
0citations -
A mechanism-based model of immune status effects on antibiotic PK/PD targets in bacteremia2026 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Antibiotics Pharmacokinetics and Efficacy Open access
Marinda van de Kreeke, Anh Duc Pham, Michelle Mehciz, Tamara Jordens, Marnix G. Uyterlinde, Rob Christiaan van Wijk, +5 more
0citations
19 results