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Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer2022 Breast Cancer Research article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Leonie Ratz, Chiara Svetlana Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, +16 more
16citations -
Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers2025 Nature Genetics article Biochemistry, Genetics and Molecular Biology Cancer, Lipids, and Metabolism Open access
Tim Arnoldus, Alex v. Vliet, Onno B. Bleijerveld, Qinglin Piao, Niek Blomberg, Désirée Schatton, +12 more
5citations -
Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer2022 Geburtshilfe und Frauenheilkunde article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer
Leonie Ratz, Chiara Svetlana Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, +16 more
0citations -
The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer2021 Nature Cancer article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access cited by 1 patent
Salomé Adam, Silvia Emma Rossi, Nathalie Moatti, Mara De Marco Zompit, Yibo Xue, Timothy F. Ng, +19 more
119citations -
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance2021 Nature Communications article Medicine PARP inhibition in cancer therapy Open access cited by 18 patents
Diana A. Zatreanu, Helen M.R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, +53 more
370citations -
Exploiting Synthetic Lethality between Germline BRCA1 Haploinsufficiency and PARP Inhibition in JAK2V617F-Positive Myeloproliferative Neoplasms2023 International Journal of Molecular Sciences article Medicine PARP inhibition in cancer therapy Open access
Max Bermes, María Jimena Rodriguez, Marcelo A. S. Toledo, Sabrina Ernst, Gerhard Müller‐Newen, Tim H. Brümmendorf, +3 more
7citations -
Loss of the Mechanistic Target of Rapamycin Complex 1 Causes a Lethal Alpha-1 Antitrypsin Deficiency–Associated Liver Disease2026 RWTH Publications (RWTH Aachen) article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Lisa Bewersdorf, S. Haber, Ines Volkert, Katharina Remih, Annika Groß, Christian Preisinger, +11 more
0citations -
Finding novel vulnerabilities of hypomorphic BRCA1 alleles2026 Molecular Oncology article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Gois, Rosalie A. Kampen, Marta San Martín Alonso, +5 more
0citations -
603O First clinical results from a phase I trial of PRT3789: A first-in-class intravenous SMARCA2 degrader, in patients with advanced solid tumors with a SMARCA4 mutation2024 Annals of Oncology article Biochemistry, Genetics and Molecular Biology Chromatin Remodeling and Cancer Open access
Robin Guo, Afshin Dowlati, Ibiayi Dagogo‐Jack, Julien Vibert, Alexander I. Spira, Victor Moreno Garcia, +12 more
15citations -
A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection2022 Nature Communications article Medicine SARS-CoV-2 and COVID-19 Research Open access cited by 2 patents
Iris N. Pardieck, Tetje Cornelia van der Sluis, Esmé T.I. van der Gracht, Dominique M. B. Veerkamp, Felix M. Behr, Suzanne van Duikeren, +20 more
54citations -
CpG-ODN induced antimicrobial immunity in neonatal chicks involves a substantial shift in serum metabolic profiles2021 Scientific Reports article Immunology and Microbiology Immune Response and Inflammation Open access
Kalhari Bandara Goonewardene, Naama Karu, Khawaja Ashfaque Ahmed, Shelly Popowich, Betty Chow-Lockerbie, Lisanework E. Ayalew, +9 more
10citations -
Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control2026 Science Advances article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access
Nila K. van Overbeek, Linda Clijsters, Martina Wirth, Ilona J. de Graaf, Klaas de Lint, Sidrit Uruci, +12 more
0citations
21 results