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Abstract PR009: Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal cancers2024 Molecular Cancer Therapeutics conference-abstract Biochemistry, Genetics and Molecular Biology Cancer, Lipids, and Metabolism
Tim Arnoldus, Alex van Vliet, Adriaan F. Hubertus de Groot, Niek Blomberg, Onno B. Bleijerveld, Susan E. van Hal-van Veen, +6 more
0citations -
Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer2022 Breast Cancer Research article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Leonie Ratz, Chiara Svetlana Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, +16 more
16citations -
Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers2025 Nature Genetics article Biochemistry, Genetics and Molecular Biology Cancer, Lipids, and Metabolism Open access
Tim Arnoldus, Alex v. Vliet, Onno B. Bleijerveld, Qinglin Piao, Niek Blomberg, Désirée Schatton, +12 more
5citations -
EZH2 Inhibition Sensitizes BRCA1-Deficient Breast Cancer to Synthetic Lethal Therapy with ATM Inhibitors2021 Research Square preprint Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Leonie Ratz, Chiara Svetlana Brambillasca, Leandra Bartke, Marieke van de Ven, Natalie Proost, Bjørn Siteur, +12 more
0citations -
Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer2022 Geburtshilfe und Frauenheilkunde article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer
Leonie Ratz, Chiara Svetlana Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, +16 more
0citations -
Abstract B001: Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal cancers2024 Molecular Cancer Therapeutics conference-abstract Biochemistry, Genetics and Molecular Biology Cancer, Lipids, and Metabolism
Tim Arnoldus, Alex van Vliet, Adriaan F. Hubertus de Groot, Niek Blomberg, Onno B. Bleijerveld, Susan E. van Hal-van Veen, +6 more
0citations -
The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer2021 Nature Cancer article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access cited by 1 patent
Salomé Adam, Silvia Emma Rossi, Nathalie Moatti, Mara De Marco Zompit, Yibo Xue, Timothy F. Ng, +19 more
119citations -
Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal cancers2023 Research Square preprint Biochemistry, Genetics and Molecular Biology Cancer, Lipids, and Metabolism Open access
Tim Arnoldus, Alex van Vliet, Niek Blomberg, Onno B. Bleijerveld, Susan E. van Hal-van Veen, Anita E. Grootemaat, +5 more
0citations -
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance2021 Nature Communications article Medicine PARP inhibition in cancer therapy Open access cited by 18 patents
Diana A. Zatreanu, Helen M.R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, +53 more
370citations -
Abstract P056: Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance2021 Molecular Cancer Therapeutics conference-abstract Medicine PARP inhibition in cancer therapy cited by 1 patent
Diana A. Zatreanu, Helen M.R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, +42 more
3citations -
Exploiting Synthetic Lethality between Germline BRCA1 Haploinsufficiency and PARP Inhibition in JAK2V617F-Positive Myeloproliferative Neoplasms2023 International Journal of Molecular Sciences article Medicine PARP inhibition in cancer therapy Open access
Max Bermes, María Jimena Rodriguez, Marcelo A. S. Toledo, Sabrina Ernst, Gerhard Müller‐Newen, Tim H. Brümmendorf, +3 more
7citations -
Loss of the Mechanistic Target of Rapamycin Complex 1 Causes a Lethal Alpha-1 Antitrypsin Deficiency–Associated Liver Disease2026 RWTH Publications (RWTH Aachen) article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Lisa Bewersdorf, S. Haber, Ines Volkert, Katharina Remih, Annika Groß, Christian Preisinger, +11 more
0citations -
Finding novel vulnerabilities of hypomorphic BRCA1 alleles2026 Molecular Oncology article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Gois, Rosalie A. Kampen, Marta San Martín Alonso, +5 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Anne Schreuder, Klaas de Lint, Mariana M. Gois, Rosalie A. Kampen, Marta San Martín Alonso, Ilse Nootenboom, +3 more
0citations