Papers matching “safety and tolerability” 650
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First-in-human study to evaluate safety, tolerability, and immunogenicity of heterologous regimens using the multivalent filovirus vaccines Ad26.Filo and MVA-BN-Filo administered in different sequences and schedules: A randomized, controlled study
Viki Bockstal, Georgi Shukarev, Chelsea M. McLean, Neil H. Goldstein, Stephan Bart, Auguste Gaddah, +12 more
34citations -
A first-in-human, phase 1 dose escalation and expansion study evaluating the safety, tolerability, and anti-tumor activity of [225Ac]Ac-FL-020, an anti-PSMA radioconjugate, in patients with metastatic castration-resistant prostate cancer (mCRPC).2025 Journal of Clinical Oncology conference-abstract Medicine Radiopharmaceutical Chemistry and Applications
Andrei H. Iagaru, GIUSEPPE T. CARDACI, Aaron Richard Hansen, Jeffrey Y.C. Wong, Carlos Artigas, Karolien E. Goffin, +7 more
0citations -
A randomized, double-blind, placebo-controlled, mechanistic trial on the safety, tolerability and pharmacodynamics of ninerafaxstat in patients with angina and chronic coronary syndrome
Juhani M. Knuuti, Roni Ranghoej Nielsen, Jerome J. Bax, Lars Christian Gormsen, Frank Arnold Flachskampf, Christina Jespersen, +8 more
0citations -
Safety, Tolerability, and Immunogenicity of the InvaplexAR-Detox Shigella Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protocol for a Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Phase Ia/b Clinical Trial2025 Vaccines article Biochemistry, Genetics and Molecular Biology Escherichia coli research studies Open access
Geert V.T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, +15 more
3citations -
Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Antitumor Activity of the Cyclin-Dependent Kinase-9 (CDK9) Inhibitor AZD4573 in Relapsed/Refractory Hematological Malignancies: A Phase 1 First-in-Human Study
Tim H. Brümmendorf, Patrick G. Medd, Raphael Koch, Stephan Stilgenbauer, Shringi Sharma, Yun He, +4 more
8citations -
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Muscarinic M3 Receptor‐Positive Allosteric Modulator ASP8302 Following Single and Multiple Ascending Oral Doses in Healthy Volunteers2024 Clinical Pharmacology in Drug Development article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Shin Takusagawa, Nicoline Treijtel, Masako Saitō, Ingrid N. Michon, Daisuke Miyatake, Fumio Osaki, +8 more
2citations -
First‐in‐human trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of STR‐324, a dual enkephalinase inhibitor for pain management2021 British Journal of Clinical Pharmacology article Medicine Pain Mechanisms and Treatments Open access
Laurence M. Moss, Cécile L. Berends, Emilie M.J. van Brummelen, Ingrid M. C. Kamerling, Erica Surya Klaassen, Kirsten Riber Bergmann, +4 more
11citations -
A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes2020 Diabetologia article Biochemistry, Genetics and Molecular Biology Diabetes and associated disorders Open access cited by 2 patents
Bart Keymeulen, André van Maurik, João Joaquim de Oliveira, Rene J. McLaughlin, Rachel Gittelman, Bart O. Roep, +7 more
51citations -
P537: SAFETY AND TOLERABILITY OF AZD0466 AS MONOTHERAPY FOR PATIENTS WITH ADVANCED HEMATOLOGICAL MALIGNANCIES - PRELIMINARY RESULTS FROM AN ONGOING PHASE I/II TRIAL2023 HemaSphere article Biochemistry, Genetics and Molecular Biology Cell death mechanisms and regulation Open access
Giovanni Marconi, Shukaib Arslan, Shaun A. Fleming, Antonio Curti, James Stewart Blachly, Giovanni Martinelli, +15 more
0citations -
Safety, Tolerability, and Pharmacokinetics of the Neuroprotectant 2-Iminobiotin in Patients With Large-Vessel Occlusion Ischemic Stroke Treated With Endovascular Thrombectomy
Erik M. Vos, Cacha M. P. C. D. Peeters‐Scholte, Jelis Boiten, Hajo M. Hund, Korné Jellema, Raoul P. Kloppenborg, +9 more
2citations -
Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study
Annette Janus, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, +2 more
4citations -
Safety, tolerability and pharmacokinetic characterisation of DACRA KBP‐042 in healthy male subjects2021 British Journal of Clinical Pharmacology article Medicine Diabetes Treatment and Management Open access
Kim Henriksen, Karen Broekhuizen, Wadim M. I. de Boon, M.A. Karsdal, Asger Reinstrup Bihlet, Claus Christiansen, +5 more
16citations -
Long‐Term Efficacy, Safety, and Tolerability of Alirocumab in 8242 Patients Eligible for 3 to 5 Years of Placebo‐Controlled Observation in the ODYSSEY OUTCOMES Trial2023 Journal of the American Heart Association article Medicine Lipoproteins and Cardiovascular Health Open access
Shaun G. Goodman, Philippe Gabríel Steg, Yann Poulouin, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, +8 more
43citations -
Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagement2021 British Journal of Clinical Pharmacology article Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders cited by 3 patents
Michelle L. Mellion, Lucienne V. Ronco, Cécile L. Berends, Lisa Pagan, Sander Brooks, Michiel Joost van Esdonk, +10 more
41citations -
Safety and Tolerability of AZD0466 As Monotherapy for Patients with Advanced Hematologic Malignancies. Results from a Phase I/II Trial2023 Blood conference-abstract Biochemistry, Genetics and Molecular Biology Cell death mechanisms and regulation
Shukaib Arslan, Giovanni Marconi, Giovanni Martinelli, Shaun A. Fleming, Antonio Curti, Shira Naomi Dinner, +19 more
5citations -
Pharmacokinetics, safety, tolerability and fluorescence imaging of nizaracianine triflutate administered in three divided doses to healthy volunteers2026 British Journal of Clinical Pharmacology article Medicine Optical Imaging and Spectroscopy Techniques Open access
Lisanne K. A. Neijenhuis, Cedric M. W. Pesch, John V. Frangioni, Alexander L. Vahrmeijer, Jacobus Burggraaf, Naomi B. Klarenbeek
0citations -
First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring2023 Drug Delivery article Pharmacology, Toxicology and Pharmaceutics Advanced Drug Delivery Systems Open access cited by 1 patent
Willem N.G.M. de Laat, Lisa Pagan, Karl R. Malcolm, Maarten Wiegerinck, Victor J. Nickolson, Bertine W. Huisman, +3 more
14citations -
Safety, Tolerability and Efficacy of Narsoplimab, a Novel MASP-2 Inhibitor for the Treatment of IgA Nephropathy2020 Kidney International Reports article Medicine Renal Diseases and Glomerulopathies Open access cited by 18 patents
Richard A. Lafayette, Brad H. Rovin, Heather N. Reich, James Alan Tumlin, Jürgen Floege, Jonathan Barratt
161citations