Papers matching “pharmacodynamic evaluation” 143
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Apply-PNH: Analysis of complement pathway biomarkers provides evidence for pharmacodynamic response in PNH patients who receive oral iptacopan monotherapy versus continuing anti-C5 therapy2025 Blood conference-abstract Immunology and Microbiology Complement system in diseases Open access
Régis Peffault de Latour, Richard Kelly, Austin Gladston Kulasekararaj, Alexander Röth, Phillip Scheinberg, Yasutaka Ueda, +4 more
0citations -
Alemtuzumab Exposure and T Lymphocyte Depletion: A Population Pharmacokinetic‐Pharmacodynamic Model of Alemtuzumab Induction Therapy for Kidney Transplantation2025 Clinical Pharmacology & Therapeutics article Medicine Renal Transplantation Outcomes and Treatments Open access
Lukas K. van Vugt, Tom C. Zwart, Suzanne Bezstarosti, Sebastiaan Heidt, Marlies E. J. Reinders, Dennis Alexander Hesselink, +3 more
2citations -
Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development2026 Clinical Pharmacology & Therapeutics article Immunology and Microbiology Immunotoxicology and immune responses Open access
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, +6 more
0citations -
Strain-dependent variability in pharmacodynamic interactions for phage-antibiotic combinations in Pseudomonas aeruginosa2026 International Journal of Antimicrobial Agents article Environmental Science Bacteriophages and microbial interactions Open access
Laura R. Baars, Meng Gu, Tingjie Guo, J. G. Coen van Hasselt
2citations -
Glycoprotein Non‐Metastatic Melanoma Protein B ( GPNMB ): A Translational Pharmacodynamic Biomarker for PIKfyve Inhibition With VRG506352026 Clinical and Translational Science article Medicine Amyotrophic Lateral Sclerosis Research Open access
Géraldine Gontier, Grace Kim, Chao Wang, Raymond Gau, Ningzhe Zhang, Swati B. Naphade, +11 more
0citations -
Towards Fixed Dosing of Tocilizumab in ICU-Admitted COVID-19 Patients: Results of an Observational Population Pharmacokinetic and Descriptive Pharmacodynamic Study
Dirk Jan A. R. Moes, David J. van Westerloo, Sandra M. Arend, Jesse Joachim Swen, Annick de Vries, Henk‐Jan Guchelaar, +4 more
16citations -
Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study
Annette Janus, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, +2 more
4citations -
Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans2020 Translational Psychiatry article Neuroscience Neurotransmitter Receptor Influence on Behavior Open access cited by 2 patents
Giacomo Salvadore, Pascal Bonaventure, Anantha Shekhar, Philip L. Johnson, Brian Lord, Brock T. Shireman, +14 more
51citations -
Pharmacodynamic Profiles of Patients (Pts) with Newly Diagnosed (ND) Vs Relapsed/Refractory Multiple Myeloma (RRMM) Who Received Teclistamab (Tec) or Talquetamab (Tal) Plus Daratumumab (Dara) and Lenalidomide (Len) in the Phase 1b Majestec-2 and Monumental-2 Studies
Brendan Paul Hodkinson, Ashwini Kumar, Sheri Skerget, Gary E. Mason, Elizabeth Shearin, Hein Ludlage, +26 more
1citations -
Evaluation of single-strain Prevotella histicola on KLH-driven immune responses in healthy volunteers: A randomized controlled trial with EDP18152023 Medicine in Microecology article Agricultural and Biological Sciences Probiotics and Fermented Foods Open access
Mahdi Saghari, Pim Gal, Hendrika W. Grievink, Erica Surya Klaassen, Ahnjili Zhuparris, Andrea A. Itano, +3 more
0citations -
Comprehensive evaluation of microneedle‐based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial2021 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Advancements in Transdermal Drug Delivery Open access
Justin Jacobse, Wouter ten Voorde, Anushka Tandon, Stefan G. Romeijn, Hendrika W. Grievink, Koen van der Maaden, +16 more
32citations -
Characterization of the Pharmacokinetic and Pharmacodynamic Profile of Apraglutide, a Glucagon-Like Peptide-2 Analog, in Healthy Volunteers2023 Journal of Pharmacology and Experimental Therapeutics article Nursing Clinical Nutrition and Gastroenterology Open access
Federico Bolognani, Annelieke C. Kruithof, Pascal Schulthess, Matthias Macháček, Marieke L. de Kam, Kirsten Riber Bergmann, +5 more
9citations -
Fixed dosing of tocilizumab in ICU admitted COVID-19 patients is a superior choice compared to bodyweight based dosing; an observational population pharmacokinetic and pharmacodynamic study
Dirk Jan A. R. Moes, David J. van Westerloo, Sandra M. Arend, Jesse Joachim Swen, Annick de Vries, Henk‐Jan Guchelaar, +4 more
3citations -
Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS)
Kathryn Thomson, Calie Dyer, Feiyan Liu, Kirsty M. Sands, Edward A. R. Portal, Maria J. Carvalho, +79 more
138citations -
Model‐based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug‐resistant tuberculosis2023 British Journal of Clinical Pharmacology article Medicine Tuberculosis Research and Epidemiology Open access
Krina Mehta, Tingjie Guo, Piet H. van der Graaf, J. G. Coen van Hasselt
10citations -
Time‐to‐Event Modeling for Remimazolam for the Indication of Induction and Maintenance of General Anesthesia2020 The Journal of Clinical Pharmacology article Medicine Anesthesia and Sedative Agents Open access
Lauren L. Lohmer, Frank Schippers, Karl Uwe Petersen, Thomas Stoehr, Virginia D. Schmith
90citations