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Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk
Anita M. van den Hoek, Jelle C. B. C. de Jong, Nicole Worms, Anita van Nieuwkoop, Marijke Voskuilen, Aswin L. Menke, +4 more
53citations -
Diffusion‐tensor magnetic resonance imaging captures increased skeletal muscle fibre diameters in Becker muscular dystrophy2023 Journal of Cachexia Sarcopenia and Muscle article Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
Donnie Cameron, Tooba Abbassi‐Daloii, Laura G.M. Heezen, Nienke M. van de Velde, Zaïda Koeks, Thom T. J. Veeger, +10 more
23citations -
Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy2020 Journal of Neuromuscular Diseases article Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
Ingrid E.C. Verhaart, Ornella Cappellari, Christa L. Tanganyika-de Winter, Jaap J. Plomp, Sofia Nnorom, Kim E. Wells, +3 more
17citations -
Efficient Downregulation of Alk4 in Skeletal Muscle After Systemic Treatment with Conjugated siRNAs in a Mouse Model for Duchenne Muscular Dystrophy2022 Nucleic Acid Therapeutics article Biochemistry, Genetics and Molecular Biology RNA Interference and Gene Delivery Open access
Sarah Engelbeen, Svetlana Pasteuning-Vuhman, Rubina Giare Parmar, Klaus Charissé, Laura Sepp‐Lorenzino, Muthiah A. Manoharan, +2 more
14citations -
Integrin α1β1 Promotes Interstitial Fibrosis and Cyst Growth in a Mouse Model of Polycystic Kidney Disease2025 Journal of the American Society of Nephrology article Biochemistry, Genetics and Molecular Biology Genetic and Kidney Cyst Diseases Open access
Céline Grenier, I‐Hsuan Lin, Dorien J.M. Peters, Ambra Pozzi, Rachel Lennon, Richard William Naylor
3citations -
Antisense oligonucleotide-mediated terminal intron retention of endoglin: A potential strategy to inhibit renal interstitial fibrosis2024 Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease article Medicine Chronic Kidney Disease and Diabetes Open access
Tessa Gerrits, Kyra L. Dijkstra, Jan Anthonie Bruijn, Marion Scharpfenecker, Roel Bijkerk, Hans J. Baelde
4citations -
Association of endothelial to mesenchymal transition and cellular senescence with fibrosis in skin biopsies of systemic sclerosis patients: a cross-sectional study2022 Clinical and Experimental Rheumatology article Medicine Systemic Sclerosis and Related Diseases Open access
Yu‐Hsiang Chiu, Julia Spierings, Jacob M. van Laar, Jeska Kirsten De Vries-Bouwstra, Marijke R. van Dijk, Roel Goldschmeding
15citations -
Towards Bayesian-based quantitative adverse outcome pathways using in vitro data from open literature and continuous variables: a case example for liver fibrosis2026 Toxicological Sciences article Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Robin Durník, Tereza Juchelková, Helge Hecht, Levi M. T. Winkelman, Joost B. Beltman, Xavier Coumoul, +4 more
0citations -
Response to: Low molecular weight guluronate: A potential therapies for inspiratory muscle dysfunction and restrictive lung function impairment in congenital heart disease by Guiyuan He, Ruiting Zhou, Tingyuan Huang, Fanjun Zeng
Jens Spießhoefer, Binaya Regmi, Stefan Orwat, Hans‐Joachim Kabitz, Alberto Giannoni, Michael Dreher, +2 more
0citations -
Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases2021 Journal of Cachexia Sarcopenia and Muscle article Medicine Liver Disease Diagnosis and Treatment Open access
David P.J. van Dijk, Junfang Zhao, Katrin Kemter, Vickie Elaine Baracos, Cornelis H.C. Dejong, Sander S. Rensen, +1 more
33citations -
Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease2021 Cancers article Biochemistry, Genetics and Molecular Biology Endoplasmic Reticulum Stress and Disease Open access
Chaobo Chen, Hanghang Wu, Hui Ye, Agustín Tortajada, Sandra Rodríguez, Raúl Torres-Ruiz, +23 more
8citations -
Activation of the unfolded protein response (UPR) and fibrosis is associated withcholangiocellular injury in an experimental model of fibropolycystic liver disease2022 Zeitschrift für Gastroenterologie article Biochemistry, Genetics and Molecular Biology Endoplasmic Reticulum Stress and Disease
Hanghang Wu, Chaobo Chen, Hui Ye, Agustín Tortajada, Sandra Rodríguez, Raúl Torres-Ruiz, +16 more
0citations -
Characterization of patients with Becker muscular dystrophy by histology, magnetic resonance imaging, function, and strength assessments2021 Muscle & Nerve article Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
Giacomo P. Comi, Erik Harmen Niks, Claudia Maria Cinnante, Hermien E. Kan, Krista Vandenborne, Rebecca J. Willcocks, +8 more
15citations -
Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models2023 Nature Communications article Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
Laura G.M. Heezen, Tamim Abdelaal, Maaike van Putten, Annemieke M Aartsma-Rus, Ahmed Essam Mahfouz, Pietro Spitali
55citations -
Unraveling the spatial landscape of dystrophinopathies: a transcriptomic approach to Becker and Duchenne muscular dystrophies2026 The Journal of Pathology article Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
L. Heezen, Stefan Nicolau, Julia van der Weerd, Jan Kueckelhaus, Jordi Díaz‐Manera, Hermien E. Kan, +6 more
2citations -
Histone deacetylase inhibition with givinostat: a multi-targeted mode of action with the potential to halt the pathological cascade of Duchenne muscular dystrophy22citations