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A novel genetic strategy to interrogate an unknown phenotypic modifier: an Sdhc KO-Robertsonian mouse with a semi-homologous chromosome develops papillary thyroid carcinoma-like tumours0citations
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Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Genetics, Aging, and Longevity in Model Organisms Open access
Mara Neuerburg, Larissa Smulders, Erik B. van den Akker, Daniel Kolbe, Filippo Artoni, Isabell Brusius, +10 more
0citations -
Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Genetics, Aging, and Longevity in Model Organisms Open access
Helena M. Hinterding, Maarouf Baghdadi, Thies Gehrmann, Pasquale C. Putter, Mara Neuerburg, Nico Lakenberg, +4 more
0citations -
Transformation of primary murine peritoneal mast cells by constitutive KIT activation as a result of lost Cdkn2a/Arf expression2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Mast cells and histamine Open access
Sandro Capellmann, Herdit M. Schüler, Steffen K. Meurer, Lin Gan, Marlies Kauffmann, Katharina Horn, +4 more
0citations -
The Plasmodium falciparum CCCH zinc finger protein ZNF4 plays an important role in gametocyte exflagellation through the regulation of male gametocyte enriched transcripts2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Malaria Research and Control Open access
Borja Hanhsen, Afia Farrukh, Gabriele Pradel, Che Julius Ngwa
6citations -
Roles for the long non-coding RNA Pax6os1 / PAX6-AS1 in pancreatic beta cell identity and function2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Pancreatic function and diabetes Open access
Livia López–Noriega, Rebecca Callingham, Aida Martínez-Sánchez, Sameena Nawaz, Grazia Pizza, Nejc Haberman, +13 more
6citations -
Pulmonary ductal coarctation and left pulmonary artery interruption; pathology and role of neural crest and second heart field during development2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Congenital heart defects research Open access
Adriana C. Gittenberger–de Groot, Joshua Craiger Peterson, Lambertus J. Wisse, Arno A.W. Roest, Robert E. Poelmann, Regina Bökenkamp, +5 more
5citations -
PCSK9 affects expression of key surface proteins in human pancreatic beta cells through intra- and extracellular regulatory circuits2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Pancreatic function and diabetes Open access
Kevin Saitoski, Maria Ryaboshapkina, Ghaith M. Hamza, Andrew F. Jarnuczak, Claire Berthault, Françoise Carlotti, +7 more
1citations -
Targeting M2-TAM via STAT3/NF-kB/AKT Signaling Pathway With Oxaliplatin, Retinoic Acid, and Libidibia ferrea -Loaded Extracellular Vesicles From Macrophages 1 Down-Regulates Murine Colon Cancer Metastasis2023 Preprints.org preprint Biochemistry, Genetics and Molecular Biology Extracellular vesicles in disease Open access
Thaís Gomes de Carvalho, Pablo Lara, Carla Jorquera‐Cordero, Timo Schomann, Cícero Flávio Soares Aragão, Artur de Santana Oliveira, +6 more
1citations -
FOXP1 differentially regulates the development of murine vasopressin and oxytocin magnocellular neurons2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Psychology Neuroendocrine regulation and behavior Open access
Jari B. Berkhout, Sophie Trender, Quirin Krabichler, Yuval Podpecan, J. Peter H. Burbach, Valery Grinevich, +5 more
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Tsc1 haploinsufficiency leads to Pax2 dysregulation in the developing murine cerebellum2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Tuberous Sclerosis Complex Research Open access
Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, +1 more
0citations -
Itaconate enhances oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways2023 Research Square preprint Biochemistry, Genetics and Molecular Biology Virus-based gene therapy research Open access
Naziia Kurmasheva, Aida Said, Boaz Wong, Alena Kress, Zhenlong Liu, Chen Wang, +34 more
0citations -
The Brugada syndrome associated gene WT1 impacts on SCN5A expression and cardiac conduction2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cardiac electrophysiology and arrhythmias Open access
E. Madelief Marsman, Joost Allard Offerhaus, Thomas Stervinou, Leander Beekman, Simona Casini, T J Streef, +11 more
0citations -
A resource for generating and manipulating human microglial states in vitro2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Neuroinflammation and Neurodegeneration Mechanisms Open access
Michael-John Dolan, Martine Therrien, Saša Jereb, Tushar Kamath, Trevor Atkeson, Samuel E. Marsh, +16 more
12citations -
The enzymatic activity of the nsp14 exoribonuclease is critical for replication of Middle East respiratory syndrome-coronavirus2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine SARS-CoV-2 and COVID-19 Research Open access
Natacha S. Ogando, Jessika C. Zevenhoven-Dobbe, Clara C. Posthuma, Eric J. Snijder
8citations -
Deep and accurate detection of m 6 A RNA modifications using miCLIP2 and m6Aboost machine learning2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology RNA modifications and cancer Open access
Nadine Körtel, Cornelia Rücklé, You Zhou, Anke Busch, Peter Hoch-Kraft, F.X. Reymond Sutandy, +12 more
3citations -
Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Advanced Fluorescence Microscopy Techniques Open access
Aaron L. Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet E. M. Blom, Bruce N. Cohen, +13 more
2citations -
Glucose-dependent miR-125b is a negative regulator of β-cell function2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Pancreatic function and diabetes Open access
Rebecca Cheung, Grazia Pizza, PAULINE L. CHABOSSEAU, Delphine Rolando, Alejandra Tomás, Thomas Burgoyne, +18 more
2citations -
The interplay of TGF-β1 and cholesterol orchestrating hepatocyte cell fate, EMT, and signals for HSC activation2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Liver physiology and pathology Open access
Sai Wang, Frederik Link, Mei Han, Roohi Chaudhary, Anastasia Asimakopoulos, Roman Liebe, +11 more
1citations -
Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Protein Tyrosine Phosphatases Open access
Maaike Allers, Petra A. Bakker, Herman P. Spaink, Jeroen den Hertog
1citations -
EZH2 Inhibition Sensitizes BRCA1-Deficient Breast Cancer to Synthetic Lethal Therapy with ATM Inhibitors2021 Research Square preprint Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Leonie Ratz, Chiara Svetlana Brambillasca, Leandra Bartke, Marieke van de Ven, Natalie Proost, Bjørn Siteur, +12 more
0citations -
ACE2 decoy Fc-fusions and bi-specific killer engager (BiKEs) require Fc engagement for in vivo efficacy against SARS-CoV-22024 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine SARS-CoV-2 and COVID-19 Research Open access
Jenna K. Dick, Dustin M. Hicks, Venkatramana Divana Krishna, Jules A. Sangala, Benjamin T. Zandstra, Carly Baehr, +5 more
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Mixed acid fermentation products from Lachnospira eligens counteract myotube atrophy2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Gut microbiota and health Open access
Sophie Lecop, Edwige Piron, Audrey M. Neyrinck, Axelle E. Loriot, Sarah A. Pötgens, Raphaël Helaers, +11 more
0citations
25 results