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Model‐Based Patient Selection and Dosing Strategies for HRAS and PIK3CA Dysregulated HNSCC : A QSP Model for Alpelisib and Tipifarnib Combination2026 Clinical Pharmacology & Therapeutics article Biochemistry, Genetics and Molecular Biology PI3K/AKT/mTOR signaling in cancer Open access
Jaehee V. Shim, Douglas Chung, Alison Smith, Shivani Malik, Binaifer Balsara, Francis Burrows, +2 more
2citations -
Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model2020 Journal for ImmunoTherapy of Cancer article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Sai Ping Lau, Nadine van Montfoort, Priscilla Kinderman, Melanie M. Lukkes, Larissa Klaase, Menno van Nimwegen, +15 more
65citations -
Effects of anti-RANKL, zoledronate, or combination therapy in a mouse model of fibrous dysplasia: a preclinical study2026 Journal of Bone and Mineral Research article Medicine Bone Tumor Diagnosis and Treatments Open access
Biagio Palmisano, Chiara Tavanti, Giorgia Farinacci, Alessandro Corsi, Marta Serafini, Natasha M. Appelman‐Dijkstra, +1 more
3citations -
COMBINATION THERAPY WITH A SENSE OLIGONUCLEOTIDE TO INDUCIBLE NITRIC OXIDE SYNTHASE MRNA AND HUMAN SOLUBLE THROMBOMODULIN IMPROVES SURVIVAL OF SEPSIS MODEL RATS AFTER PARTIAL HEPATECTOMY
Richi Nakatake, Masaya Kotsuka, Morihiko Ishizaki, Hiroaki Kitade, Katsuhiko Yoshizawa, Rene Hany Tolba, +2 more
3citations -
Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model2023 Frontiers in Molecular Biosciences article Biochemistry, Genetics and Molecular Biology Genetic and Kidney Cyst Diseases Open access
Xuewen Song, Wouter N. Leonhard, Anish A. Kanhai, Gregory R. Steinberg, York Pei, Dorien J.M. Peters
7citations -
The Extension of the LeiCNS-PK3.0 Model in Combination with the “Handshake” Approach to Understand Brain Tumor Pathophysiology2022 Pharmaceutical Research article Neuroscience Barrier Structure and Function Studies Open access
Makoto Hirasawa, Mohammed A. A. Saleh, Elizabeth C. M. de Lange
7citations -
Combination of searches for heavy vector boson resonances in proton-proton collisions at $$ \sqrt{s}=13 $$ TeV2026 Journal of High Energy Physics article Physics and Astronomy Particle physics theoretical and experimental studies Open access
A Hayrapetyan, В. Макаренко, A. Tumasyan, W. Adam, L. Benato, T. Bergauer, +93 more
0citations -
#2295 Characterization and standard of care efficacy testing in a translational mouse model of cardiovascular-kidney-metabolic syndrome2025 Nephrology Dialysis Transplantation article Medicine Chronic Kidney Disease and Diabetes Open access
Arianne van Koppen, Anke M. Smits, Tri Quang Nguyen, Amélie Dendooven, Ingeborg M. Bajema, Harry van Goor, +5 more
0citations -
Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies2020 Molecular Systems Biology article Biochemistry, Genetics and Molecular Biology Gene Regulatory Network Analysis Open access
Federica Eduati, Patricia Jaaks, Jessica Wappler, Thorsten Cramer, Christoph A. Merten, Mathew J. Garnett, +1 more
79citations -
Therapeutic liposomal combination to enhance chemotherapy response and immune activation of tumor microenvironment2024 Journal of Controlled Release article Materials Science Nanoparticle-Based Drug Delivery Open access
Zili Gu, Jie Yin, Candido G. Da Silva, Qi Liu, Luis Javier Cruz, FERRY A. OSSENDORP, +1 more
14citations -
Antagonistic interaction between posaconazole and olorofim in a murine model of invasive pulmonary aspergillosis2025 Journal of Antimicrobial Chemotherapy article Medicine Antifungal resistance and susceptibility Open access
Christopher A. Darlow, Nicola Farrington, Anne‐Grete Märtson, Adam J. Johnson, Laura McEntee, Iona Horner, +4 more
7citations -
Immune checkpoint inhibition combined with targeted therapy using a novel virus-like drug conjugate induces complete responses in a murine model of local and distant tumors2023 Cancer Immunology Immunotherapy article Medicine Cancer Immunotherapy and Biomarkers Open access cited by 1 patent
Ruben V. Huis in ‘t Veld, Sen Ma, Rhonda C. Kines, Anneli Savinainen, Cadmus Collins Rich, FERRY A. OSSENDORP, +1 more
19citations -
#1311 Cardiac damage in a multifactorial DKD/CKD mouse model resembles HFpEF and can be reduced by standard-of-care treatment2024 Nephrology Dialysis Transplantation article Medicine Chronic Kidney Disease and Diabetes Open access
Arianne van Koppen, Elsbet Jantine Pieterman, Simon A. Hinke, Tri Quang Nguyen, Amélie Dendooven, Ingeborg M. Bajema, +3 more
0citations -
Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure2021 Nephrology Dialysis Transplantation article Medicine Parathyroid Disorders and Treatments Open access cited by 1 patent
Aegida Neradová, Grzegorz B. Wasilewski, Selene Prisco, Peter J. A. Leenders, Marjolein M. J. Caron, Tim J. M. Welting, +5 more
18citations -
Human organoid biofilm model for assessing antibiofilm activity of novel agents2021 npj Biofilms and Microbiomes article Biochemistry, Genetics and Molecular Biology Bacterial biofilms and quorum sensing Open access
Bing Catherine Wu, Evan F. Haney, Noushin Akhoundsadegh, Daniel Pletzer, Michael J. Trimble, Alwin E. Adriaans, +2 more
63citations -
The shapes of elongating gastruloids are consistent with convergent extension driven by a combination of active cell crawling and differential adhesion2024 PLoS Computational Biology article Biochemistry, Genetics and Molecular Biology Developmental Biology and Gene Regulation Open access
Esmée Adegeest, Noémie M. L. P. Bérenger-Currias, Maria Mircea, Roeland M. H. Merks, Stefan Semrau
24citations -
A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis2022 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Sepsis Diagnosis and Treatment Open access
Feiyan Liu, Linda B. S. Aulin, Sebastiaan S. A. Kossen, Julius Cathalina, Marlotte Bremmer, Amanda C. Foks, +3 more
11citations