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mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine
Jana Sophia Buhre, Tamás Pongrácz, Inga Künsting, Anne Sophie Lixenfeld, Wenjun Wang, Jan Nouta, +14 more
91citations -
mRNA Expression Level of ALK in Neuroblastoma Is Associated with Histological Subtype, ALK Mutations and ALK Immunohistochemical Protein Expression2024 Journal of Molecular Pathology article Medicine Neuroblastoma Research and Treatments Open access
Rixt S. Bruinsma, Marta F. Fiocco, Wendy W.J. de Leng, Lennart A. Kester, Karin P.S. Langenberg, Godelieve A.M. Tytgat, +4 more
1citations -
Together is Better: mRNA Co‐Encapsulation in Lipoplexes is Required to Obtain Ratiometric Co‐Delivery and Protein Expression on the Single Cell Level2021 Advanced Science article Biochemistry, Genetics and Molecular Biology RNA Interference and Gene Delivery Open access
Heyang Zhang, Jeroen Bussmann, Florian Hendric Huhnke, Joke Devoldere, An‐Katrien Minnaert, Wim Jiskoot, +6 more
37citations -
Premature termination codons in the DMD gene cause reduced local mRNA synthesis2020 Proceedings of the National Academy of Sciences article Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
Raquel García‐Rodríguez, Monika Hiller, Laura Jiménez-Gracia, Zarah van der Pal, Judit Balog, Kevin Adamzek, +2 more
80citations -
Impact of immunosuppressive treatment and type of SARS-CoV-2 vaccine on antibody levels after three vaccinations in patients with chronic kidney disease or kidney replacement therapy
Pim Bouwmans, A. Lianne Messchendorp, Céline Imhof, Jan‐Stephan Sanders, Luuk B. Hilbrands, Marlies E. J. Reinders, +37 more
17citations -
Reduced PABPN1 levels causes cytoskeleton disorganization and aberrant differentiation2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
Cyriel Sebastiaan Olie, Erik van der Wal, Cikes Domagoj, Loes Maton, Jessica C. de Greef, I‐Hsuan Lin, +5 more
0citations -
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation2023 EMBO Molecular Medicine article Biochemistry, Genetics and Molecular Biology RNA Research and Splicing Open access
Arjan F. Theil, Alex Pines, Tuğba Kalaycı, José María Heredia‐Genestar, Anja Raams, Marion H. Rietveld, +14 more
12citations -
Elucidating another level of epigenetic regulation in osteoarthritis by identifying functional cis -acting long non-coding RNAs and their targets in articular cartilage2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Osteoarthritis Treatment and Mechanisms Open access
Marcella van Hoolwerff, Paula I. Metselaar, Margo Tuerlings, H. Eka D. Suchiman, Nico Lakenberg, Y.F. Ramos, +6 more
0citations -
Impact of prior SARS-CoV-2 acquisition on binding and neutralizing antibody responses following COVID-19 vaccination: A cross-protocol analysis of individual-level data from six phase 3 clinical trials
Aaron Hudson, Scott A. Borgetti, Anne-Marie Rick, Matthew B. Laurens, Samuel T. Robinson, Cynthia L. Gay, +24 more
0citations -
Pseudomonas mRNA 2.0: Boosting Gene Expression Through Enhanced mRNA Stability and Translational Efficiency25citations
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Alternative Polyadenylation Utilization Results in Ribosome Assembly and mRNA Translation Deficiencies in a Model for Muscle Aging2022 The Journals of Gerontology Series A article Biochemistry, Genetics and Molecular Biology RNA Research and Splicing Open access
Hailiang Mei, J. H. VAN BOOM, Salma el Abdellaoui, Kotb Abdelmohsen, Rachel Munk, Jennifer L. Martindale, +5 more
15citations -
The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not antigen-experienced vaccinees2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine SARS-CoV-2 and COVID-19 Research Open access
Julie Van Coillie, Tamás Pongrácz, Johann Rahmöller, Hung‐Jen Chen, Chiara Elisabeth Geyer, Lonneke A. van Vlught, +31 more
11citations -
In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy2023 Biomedicine & Pharmacotherapy article Biochemistry, Genetics and Molecular Biology RNA Interference and Gene Delivery Open access
Oscar Escalona-Rayo, Ye Zeng, Renzo A. Knol, Thomas J. F. Kock, Dennis Aschmann, Bram Slütter, +1 more
85citations -
Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA2025 Advanced Science article Biochemistry, Genetics and Molecular Biology RNA Interference and Gene Delivery Open access
Cheng Lin, Adrian Kuzmanović, Nan Wang, Liangliang Liao, Sabrina Ernst, Christian Penners, +16 more
5citations -
MO337: Higher Antibody Response After 2 Vaccinations With MRNA-1273 as Compared With BNT162B2 and AZD1222 in High-Risk Kidney Patients2022 Nephrology Dialysis Transplantation article Medicine SARS-CoV-2 and COVID-19 Research Open access
Pim Bouwmans, A. Lianne Messchendorp, Céline Imhof, Jan‐Stephan Sanders, Luuk B. Hilbrands, Priya Vart, +10 more
0citations -
Cellular uptake of modified mRNA occurs via caveolae-mediated endocytosis, yielding high protein expression in slow-dividing cells2023 Molecular Therapy — Nucleic Acids article Biochemistry, Genetics and Molecular Biology RNA Interference and Gene Delivery Open access
Claudia Del Toro Runzer, Shivesh Anand, Carlos Mota, Lorenzo Moroni, Christian Plank, Martijn van Griensven, +1 more
19citations