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Acetaminophen alters endogenous lipid signaling and attenuates pathological pain through a mechanism requiring diacylglycerol lipase, monoacylglycerol lipase and cannabinoid CB1 receptors in mice
Carlos Henrique Alves Jesus, Jonah L. Wirt, Taylor J. Woodward, Luana Assis Ferreira, John Hainline, Mirjam C. W. Huizenga, +5 more
2citations -
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization2024 Journal of Medicinal Chemistry article Medicine Cholinesterase and Neurodegenerative Diseases Open access
Stefania Butini, Uwe Grether, Kwang‐Mook Jung, Alessia Ligresti, Marco Allarà, Annemarieke G. J. Postmus, +18 more
8citations -
Evaluating the effect of glycation on lipase activity using boronate affinity chromatography and mass spectrometry2023 Food Chemistry article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access
Guusje van Schaick, Sanne Pot, Joost den Hartog, Michiel Akeroyd, Rob van der Hoeven, Wim Bijleveld, +4 more
3citations -
Polar Substitutions on the Surface of a Lipase Substantially Improve Tolerance in Organic Solvents2022 ChemSusChem article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access
Haiyang Cui, Markus Vedder, Lingling Zhang, Karl‐Erich Jaeger, Ulrich Schwaneberg, Mehdi D. Davari
40citations -
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence2023 Nature Communications article Medicine Cannabis and Cannabinoid Research Open access cited by 1 patent
Ming Sen Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, János Pálóczi, Avand Amedi, Richard J. B. H. N. van den Berg, +23 more
56citations -
Systematically Scrutinizing the Impact of Substitution Sites on Thermostability and Detergent Tolerance for Bacillus subtilis Lipase A2020 Journal of Chemical Information and Modeling article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization
Christina Nutschel, Alexander Fulton, Olav Zimmermann, Ulrich Schwaneberg, Karl‐Erich Jaeger, Holger Gohlke
32citations -
How Does Surface Charge Engineering of Bacillus subtilis Lipase A Improve Ionic Liquid Resistance? Lessons Learned from Molecular Dynamics Simulations2022 ACS Sustainable Chemistry & Engineering article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization
Subrata Pramanik, Haiyang Cui, Gaurao V. Dhoke, Can Bora Yildiz, Markus Vedder, Karl‐Erich Jaeger, +2 more
31citations -
Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain2022 European Journal of Medicinal Chemistry article Medicine Cannabis and Cannabinoid Research Open access
Yingfang He, Uwe Grether, Marco F. Taddio, Carla Meier, Claudia Keller, Martin R. Edelmann, +14 more
14citations -
Angiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue2022 Molecular Metabolism article Medicine Adipose Tissue and Metabolism Open access cited by 2 patents
Robin van Eenige, Wietse In het Panhuis, Milena Schönke, Céline Jouffe, Thomas H. Devilee, Ricky Siebeler, +11 more
13citations -
Deletion and Randomization of Structurally Variable Regions in B. subtilis Lipase A (BSLA) Alter Its Stability and Hydrolytic Performance Against Long Chain Fatty Acid Esters2020 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access
Ronny Martínez, Claudia Bernal, Rodrigo Álvarez, Christopher Concha, Ricardo Cabrera, Gaurao V. Dhoke, +1 more
12citations -
Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research2025 Journal of the American Chemical Society article Medicine Cannabis and Cannabinoid Research Open access
Axel Hentsch, Mónica Guberman, Silke Radetzki, Mirjam C. W. Huizenga, Yingfang He, Jörg Contzen, +18 more
12citations -
A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase2025 Angewandte Chemie International Edition article Medicine Cannabis and Cannabinoid Research Open access
Axel Hentsch, Mónica Guberman, Silke Radetzki, Mirjam C. W. Huizenga, Jérôme Paul, Jörg Benz, +13 more
10citations -
Genome-wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in Hepatic Lipase (LIPC)2020 Circulation Genomic and Precision Medicine article Medicine Lipid metabolism and disorders Open access
Dorina Ibi, Raymond Noordam, Jan Bert van Klinken, Ruifang Li‐Gao, Renée de Mutsert, Stella Trompet, +9 more
4citations -
First-in-human (phase I) trial of SOL-116, a humanised IgG4 monoclonal antibody targeting bile salt-stimulated lipase, in healthy participants and rheumatoid arthritis patients
Anouk C. Meijs, Johan Kolmert, Susanne Lindquist, Peter Hovstadius, Hendrika W. Grievink, Anneli Hällgren, +3 more
0citations -
Translational Application of the Five-Star Matrix for the Structure-Guided Optimization of a Bicyclopiperazine DEL Hit into Bcpz 1.5: A Potent Monoacylglycerol Lipase Inhibitor with Functional Inhibition in Human Brain Homogenate and Efficacy in Neuroinflammatory Models
Benjamin Brennecke, Louise Plais, Benoit Hornsperger, Martin Binder, Christian Bartelmus, Markus Bürkler, +32 more
0citations -
Inhibition of diacylglycerol lipase β modulates lipid and endocannabinoid levels in the ex vivo human placenta2023 Frontiers in Endocrinology article Biochemistry, Genetics and Molecular Biology Lipid metabolism and biosynthesis Open access
Natascha Berger, Tom van der Wel, Birgit Hirschmugl, T. Baernthaler, Juergen Gindlhuber, Nermeen Fawzy, +5 more
8citations -
Profiling of a high mannose-type N-glycosylated lipase using hydrophilic interaction chromatography-mass spectrometry2020 Analytica Chimica Acta article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access
Andrea Gargano, Guusje van Schaick, Liana S. Roca, Johanna H. van den Berg-Verleg, Rob Haselberg, Michiel Akeroyd, +2 more
25citations