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Ligand Rigidity Steers the Selectivity and Efficiency of the Photosubstitution Reaction of Strained Ruthenium Polypyridyl Complexes2023 Journal of the American Chemical Society article Chemistry Photochemistry and Electron Transfer Studies Open access
Matthijs L. A. Hakkennes, Michael S. Meijer, Jan Paul Menzel, Anne-Charlotte Goetz, Roy Van Duijn, Maxime A. Siegler, +2 more
28citations -
Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition2021 Scientific Reports article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access
Xuesong Wang, Willem Jespers, Rubén Prieto‐Díaz, María Majellaro, Adriaan P. IJzerman, Gerard J. P. van Westen, +3 more
14citations -
Perspective: Implications of Ligand–Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors2020 ACS Pharmacology & Translational Science article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Wijnand J. C. van der Velden, Laura H. Heitman, METTE MARIE ROSENKILDE
67citations -
Deciphering conformational selectivity in the A2A adenosine G protein-coupled receptor by Free Energy simulations2021 Zenodo (CERN European Organization for Nuclear Research) article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Willem Jespers, Adriaan P. IJzerman, Eddy Sotelo, Gerard J. P. van Westen, Åqvist, Hugo Gutiérrez‐de‐Terán
0citations -
Reduced Arene Complexes of Hafnium Supported by a Triamidoamine Ligand2021 Angewandte Chemie International Edition article Chemistry Organometallic Complex Synthesis and Catalysis Open access
Priyabrata Ghana, Sebastian Schrader, Thayalan Rajeshkumar, Thomas P. Spaniol, Ulli Englert, Laurent Maron, +1 more
12citations -
Design, Synthesis, and In Vitro Characterization of a Tryptamine-Based Visible-Light Photoswitchable 5-HT 2A R Ligand Showing Efficacy Preference for β-Arrestin over Mini-Gq2025 Journal of Medicinal Chemistry article Materials Science Photochromic and Fluorescence Chemistry Open access
Alexandra Sink, Eline Pottie, Samuel J. Carter, Robert J. Tombari, Verena Weber, Paolo Carloni, +4 more
6citations -
Bridging Stability and Reactivity: Novel Dinucleating Ligand With Rigid Backbone Stabilizes a Cu 2 O 2 Side‐On Peroxido Structure2026 European Journal of Inorganic Chemistry article Chemistry Metal-Catalyzed Oxygenation Mechanisms Open access
Rosalie Dalhoff, Christine Charlotte Müller, Alexander Hoffmann, Sonja Herres‐Pawlis
0citations -
Molecular basis of ligand binding and receptor activation at the human A3 adenosine receptor2025 Nature Communications article Biochemistry, Genetics and Molecular Biology Adenosine and Purinergic Signaling Open access
Liudi Zhang, Jesse I. Mobbs, Felix M. Bennetts, Hariprasad Venugopal, Anh T. N. Nguyen, Arthur Christopoulos, +5 more
7citations -
The effect of cancer-associated mutations on ligand binding and receptor function – A case for the 5-HT2C receptor2024 European Journal of Pharmacology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Chen‐Lin Feng, Rongfang Liu, Xuesong Wang, Willem Jespers, Marina Gorostiola González, Gerard J. P. van Westen, +2 more
1citations -
Halogen Bonds in Ligand–Protein Systems: Molecular Orbital Theory for Drug Design2020 Journal of Chemical Information and Modeling article Chemistry Crystallography and molecular interactions Open access
Enrico Margiotta, Stephanie C. C. van der Lubbe, Lucas de Azevedo Santos, Gábor Paragi, Stefano Moro, F. Matthias Bickelhaupt, +1 more
58citations -
Axial Ligand Tuning of the Catalytic Two- versus Four-Electron Reduction of Dioxygen by a Dinuclear Cobalt Complex2026 Journal of the American Chemical Society article Chemistry Metal-Catalyzed Oxygenation Mechanisms Open access
Ayan Bera, Xinyang Peng, Dibya Jyoti Barman, Michael Haumann, Sagie Katz, Dennis G. H. Hetterscheid, +2 more
0citations -
Multicentric Analytical and Inter-observer Comparability of Four Clinically Developed Programmed Death-ligand 1 Immunohistochemistry Assays in Advanced Clear-cell Renal Cell Carcinoma
Ulrich J. Sommer, Markus Eckstein, Johannes U Ammann, Till A. Braunschweig, Stephan Macher-Göppinger, Kristina Schwamborn, +10 more
13citations -
Impedance-based phenotypic profiling of metabotropic glutamate receptor ligand responses in SCA1 human iPSC-derived neuronal cultures2026 Neurobiology of Disease article Neuroscience Neuroscience and Neuropharmacology Research Open access
Laurie M.C. Kerkhof, Ronald A.M. Buijsen, Barry A. Pepers, Linda M. van der Graaf, Jean‐Philippe Frimat, Laura H. Heitman, +1 more
0citations -
Deciphering conformational selectivity in the A2A adenosine G protein-coupled receptor by free energy simulations2021 PLoS Computational Biology article Biochemistry, Genetics and Molecular Biology Receptor Mechanisms and Signaling Open access
Willem Jespers, Laura H. Heitman, Adriaan P. IJzerman, Eddy Sotelo, Gerard J. P. van Westen, Johan Åqvist, +1 more
9citations -
Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets2022 Biomedicine & Pharmacotherapy article Biochemistry, Genetics and Molecular Biology Estrogen and related hormone effects Open access
Laura Van Moortel, Jonathan Thommis, Brecht Maertens, Dorien Clarisse, Delphine De Sutter, Claude Libert, +4 more
20citations -
Delta-like ligand 3 expression in isocitrate dehydrogenase-mutant and isocitrate dehydrogenase-wildtype glioma is largely retained at recurrence, supporting its potential as a therapeutic target
Rosa Luning, Sybren L. N. Maas, Pim J. French, Youri Hoogstrate, Levi van Hijfte, Rania Head, +4 more
0citations -
Self-Assembled Ligand-Capped Plasmonic Au Nanoparticle Films in the Kretschmann Configuration for Sensing of Volatile Organic Compounds2022 ACS Applied Nano Materials article Materials Science Gold and Silver Nanoparticles Synthesis and Applications Open access
Rituraj Borah, Jorid Smets, Rajeshreddy Ninakanti, Max Lutz Tietze, Rob Ameloot, Dmitry N. Chigrin, +3 more
23citations