Papers matching “homologous recombination” 172
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Evaluation of homologous recombination testing in ovarian carcinoma2026 Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Vera M. Witjes, Joanne A. de Hullu, Angela van Remortele, Lilian Vreede, Efraim H. Rosenberg, Saskia A.G.M. Cillessen, +8 more
5citations -
Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks2022 Nature Communications article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access cited by 1 patent
Bert van de Kooij, Alex Kruswick, Haico van Attikum, Michael B. Yaffe
69citations -
Multi-Pathway DNA Double-Strand Break Repair Reporters Reveal Extensive Cross-Talk Between End-Joining, Single Strand Annealing, and Homologous Recombination2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Bert van de Kooij, Alex Kruswick, Haico van Attikum, Michael B. Yaffe
1citations -
ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination2022 Nucleic Acids Research article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Katja Apelt, Seong-Ok Lee, Hsin‐Ru Chan, Martijn S. Luijsterburg, Justin W. C. Leung, Kyle M. Miller
39citations -
Functional Categorization of BRCA1 Variants of Uncertain Clinical Significance in Homologous Recombination Repair Complementation Assays2020 Clinical Cancer Research article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Peter Bouwman, Ingrid van der Heijden, Hanneke van der Gulden, Roebi de Bruijn, Merel E. Braspenning, Setareh Moghadasi, +3 more
39citations -
RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?2021 Expert Review of Molecular Diagnostics article Medicine PARP inhibition in cancer therapy Open access cited by 1 patent
Lise M. van Wijk, Andreea B. Nilas, Harry Vrieling, Maaike P.G. Vreeswijk
37citations -
The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks2024 Nature Communications article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Bert van de Kooij, Fenna J. van der Wal, Magdalena B. Rother, Wouter W. Wiegant, Pau Creixell, Merula Stout, +6 more
29citations -
Prediction of homologous recombination deficiency from routine histology with attention-based multiple instance learning in nine different tumor types
Chiara Maria Lavinia Loeffler, Omar S. M. El Nahhas, Hannah Sophie Muti, Zunamys Itzell Carrero, Tobias Seibel, Marko van Treeck, +10 more
22citations -
A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair2021 Cancer Research article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Emilia M. Pulver, Chirantani Mukherjee, Gerarda van de Kamp, Stefan J. Roobol, Magdalena B. Rother, Hanneke van der Gulden, +18 more
20citations -
Direct prediction of Homologous Recombination Deficiency from routine histology in ten different tumor types with attention-based Multiple Instance Learning: a development and validation study
Chiara Maria Lavinia Loeffler, Omar S. M. El Nahhas, Hannah Sophie Muti, Tobias Seibel, Didem Çifçi, Marko van Treeck, +9 more
12citations -
RAD51 as a biomarker for homologous recombination deficiency in high‐grade serous ovarian carcinoma: robustness and interobserver variability of the RAD51 test2023 The Journal of Pathology Clinical Research article Medicine Ovarian cancer diagnosis and treatment Open access
Claire J.H. Kramer, Alba Llop‐Guevara, Elisa Yaniz‐Galende, Benedetta Pellegrino, Natalja T. ter Haar, Andrea Herencia-Ropero, +6 more
8citations -
The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaks2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Bert van de Kooij, Fenna J. van der Wal, Magdalena B. Rother, Pau Creixell, Merula Stout, Wouter W. Wiegant, +6 more
5citations -
Efficacy and safety of olaparib in patients with tumors harboring alterations in homologous recombination repair pathway associated genes: Results from the Drug Rediscovery Protocol.2024 Journal of Clinical Oncology conference-abstract Medicine PARP inhibition in cancer therapy Open access
Ilse A.C. Spiekman, Niven Mehra, Laurien Joanna Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, +10 more
3citations -
BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination2023 Science Advances article Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Rania Ghouil, Simona M. Miron, Koichi Sato, Dejan Ristić, Sari E. van Rossum-Fikkert, Pierre Legrand, +9 more
2citations -
BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Rania Ghouil, Simona M. Miron, Koichi Sato, Dejan Ristić, Sari E. van Rossum-Fikkert, Pierre Legrand, +9 more
1citations -
Data from A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair
Emilia M. Pulver, Chirantani Mukherjee, Gerarda van de Kamp, Stefan J. Roobol, Magdalena B. Rother, Hanneke van der Gulden, +18 more
0citations -
S6K1 and S6K2 regulate homologous recombination DNA repair through control of BRCA1 protein stability2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms
Mariana Marcela Góis, Lais Bonafe, L O Silva, Mariana Camargo Silva Mancini, Rosalie A. Kampen, Isadora Carolina Betim Pavan, +4 more
0citations -
Association of RAD51 with homologous recombination deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial2021 Annals of Oncology article Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access cited by 1 patent
Alba Llop‐Guevara, Sibylle Loibl, Guillermo Javierre Villacampa, Valentina A. Vladimirova, Andreas Schneeweiß, Thomas Karn, +14 more
107citations