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Ex vivo gut-hepato-biliary organ perfusion model to characterize oral absorption, gut-wall metabolism, pre-systemic hepatic metabolism and biliary excretion; application to midazolam2024 European Journal of Pharmaceutical Sciences article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Lianne J. Stevens, Evita van de Steeg, Jason B. Doppenberg, Ian P.J. Alwayn, Catherijne A. J. Knibbe, Jeroen Dubbeld
7citations -
Semi‐Physiological Population Pharmacokinetic Modeling of Oral and Intravenous Paracetamol to Quantify Presystemic Metabolism and Enterohepatic Recirculation2026 CPT Pharmacometrics & Systems Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Cedric Lau, Charlotte van Kesteren, Robert Matthijs Smeenk, Marieke Martine Beex-Oosterhuis, Birgit C. P. Koch, Lingtak‐Neander Chan, +5 more
0citations -
P28-18 Diverging endocrine disruption potential of resorcinol and paracetamol: thyroid peroxidase inhibition potency and metabolic fate differences under pharmaceutical and cosmetic use explain their contrasting endocrine disruption capabilities2025 Toxicology Letters article Environmental Science Effects and risks of endocrine disrupting chemicals
Karma C. Fussell, Sjoerd Verkaart, Joris van den Elzen, Manuela Pavan, Brunhilde Blömeke, Mira Wenker, +1 more
1citations -
Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review2020 Alcoholism Clinical and Experimental Research review Medicine Alcohol Consumption and Health Effects Open access cited by 1 patent
Janique Arnts, Benedict T. K. Vanlerberghe, Sylvia Roozen, Cleo Lina Crunelle, Ad Masclee, Steven W.M. Olde Damink, +5 more
57citations -
Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics2024 Cell Host & Microbe article Biochemistry, Genetics and Molecular Biology Gut microbiota and health Open access
Joshua B. Simpson, Morgan E. Walker, Josh J. Sekela, Samantha M. Ivey, Parth B. Jariwala, Cameron M. Storch, +15 more
66citations -
Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate2022 Gut Microbes article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina Borlandelli, Marissa M. Bivins, Natalie K. Barker, +9 more
43citations -
Metagenomics Combined with Activity-Based Proteomics Point to Gut Bacterial Enzymes that Reactivate Mycophenolate2022 medRxiv preprint Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina Borlandelli, Natalie K. Barker, Alicia A. Sorgen, +8 more
6citations -
Proof of Concept: First Pediatric [14C]microtracer Study to Create Metabolite Profiles of Midazolam2020 Clinical Pharmacology & Therapeutics article Medicine Pharmaceutical studies and practices Open access
Bianca D. van Groen, Esther van Duijn, Arjan de Vries, Miriam G. Mooij, Dick Tibboel, Wouter H. J. Vaes, +1 more
6citations -
Impact of Renal Impairment and Dialysis on the Pharmacokinetics and Pharmacodynamics of Roxadustat2020 Journal of the American Society of Nephrology article Medicine Erythropoietin and Anemia Treatment
Dorien Groenendaal‐van de Meent, Virginie Kerbusch, Rüdiger Kaspera, Maria B. Barroso, Piergiorgio Galletti, Gernot Klein, +1 more
0citations -
Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice2023 Frontiers in Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Rebekka Fendt, Ahmed Ghallab, Maiju Myllys, Ute Hofmann, Reham A. R. A. Hassan, Zaynab Hobloss, +11 more
0citations -
SO052EFFECT OF SEVERE RENAL IMPAIRMENT OR END-STAGE RENAL DISEASE ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF ROXADUSTAT, AN ORAL HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITOR2020 Nephrology Dialysis Transplantation article Medicine Erythropoietin and Anemia Treatment Open access
Dorien Groenendaal‐van de Meent, Virginie Kerbusch, Rüdiger Kaspera, Begona Barroso-Fernandez, Piergiorgio Galletti, Gernot Klein, +1 more
0citations -
The Oral Bioavailability and Metabolism of Midazolam in Stable Critically Ill Children: A Pharmacokinetic Microtracing Study2020 Clinical Pharmacology & Therapeutics article Medicine Pharmaceutical studies and practices Open access
Bianca D. van Groen, Elke H. J. Krekels, Miriam G. Mooij, Esther van Duijn, Wouter H. J. Vaes, Albert D. Windhorst, +8 more
31citations -
Field amplified sample stacking and in-capillary derivatization for forensic analysis of morphine and morphine-6-glucuronide in human urine by capillary electrophoresis2021 Talanta Open article Engineering Microfluidic and Capillary Electrophoresis Applications Open access
Walaa Zarad, Ahmed Ali, Yasmine Aboulella, Maha Kamal, Tsutomu Masujima, Samy Emara, +1 more
13citations -
Highly Sensitive In-Capillary Derivatization and Field Amplified Sample Stacking to Analyze Narcotic Drugs in Human Serum by Capillary Zone Electrophoresis2023 Separations article Engineering Microfluidic and Capillary Electrophoresis Applications Open access
Monika Malak, Hager Ebrahim, Heba Sonbol, Ahmed Ali, Yasmine Aboulella, Ghada M. Hadad, +1 more
12citations -
Discovery of novel diagnostic biomarkers for Sjögren-Larsson syndrome by untargeted lipidomics2024 Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids article Biochemistry, Genetics and Molecular Biology Metabolism and Genetic Disorders Open access
Frédéric Maxime Vaz, Pippa Staps, Jan Bert van Klinken, Henk van LENTHE, Martin A. T. Vervaart, Ronald J. A. Wanders, +6 more
8citations -
Partial dechlorination of 2,4,4′-trichlorobiphenyl (PCB 28) mediated by recombinant human CYP1A22023 Archives of Toxicology article Environmental Science Toxic Organic Pollutants Impact Open access
Isabella Eva Randerath, Natalia Quinete, Julian Peter Müller, Julia Stingl, Jens Bertram, Thomas Schettgen, +2 more
5citations