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Feasibility of Community Pharmacist-Initiated and Point-of-Care CYP2C19 Genotype-Guided De-Escalation of Oral P2Y12 Inhibitors2023 Genes article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Amar D. Levens, Melina C. den Haan, J. Wouter Jukema, Mette Heringa, Wilbert B. van den Hout, Dirk Jan A. R. Moes, +1 more
11citations -
Dutch Gastrointestinal Stromal Tumor (GIST) Registry Data Comparing Sunitinib with Imatinib Dose Escalation in Second-Line Advanced Non-KIT Exon 9 Mutated GIST Patients
Mahmoud Mohammadi, Thekla M. Werkhoven, Nikki S. IJzerman, Dide den Hollander, Roos F. Bleckman, Astrid W. Oosten, +4 more
5citations -
Randomized Study on Dose Escalation in Definitive Chemoradiation for Patients With Locally Advanced Esophageal Cancer (ARTDECO Study)2021 Journal of Clinical Oncology article Medicine Esophageal Cancer Research and Treatment Open access
Maarten C.C.M. Hulshof, Elisabeth D. Geijsen, Tom Rozema, Vera Oppedijk, Jeroen Buijsen, Karen J. Neelis, +9 more
316citations -
Planning target volume margin assessment for online adaptive MR-guided dose-escalation in rectal cancer on a 1.5 T MR-Linac2021 Radiotherapy and Oncology article Physics and Astronomy Advanced Radiotherapy Techniques Open access
Hidde Eijkelenkamp, M. Boekhoff, Maaike E. Verweij, Femke P. Peters, Gert Jacobus Meijer, Martijn Intven
41citations -
TEIPP-vaccination in checkpoint-resistant non-small cell lung cancer: a first-in-human phase I/II dose-escalation study2025 Nature Communications article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Mitchell Emmers, Marij J.P. Welters, Michelle V. Dietz, Saskia J A M Santegoets, Sanne Boekesteijn, Anouk Stolk, +12 more
17citations -
Sustained Remission and Outcomes with Abatacept plus Methotrexate Following Stepwise Dose De-escalation in Patients with Early Rheumatoid Arthritis2023 Rheumatology and Therapy article Medicine Rheumatoid Arthritis Research and Therapies Open access
Paul E. Emery, Yoshiya Tanaka, Vivian P. Bykerk, Gustavo Citera, Clifton O. Bingham, Subhashis Banerjee, +8 more
16citations -
Safety, Tolerability, and Immunogenicity of the InvaplexAR-Detox Shigella Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protocol for a Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Phase Ia/b Clinical Trial2025 Vaccines article Biochemistry, Genetics and Molecular Biology Escherichia coli research studies Open access
Geert V.T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, +15 more
3citations -
De-escalation of axillary surgery in breast cancer patients treated in the neoadjuvant setting: a Dutch population-based study2020 Breast Cancer Research and Treatment article Biochemistry, Genetics and Molecular Biology Breast Cancer Treatment Studies Open access
Janine M. Simons, Linetta B. Koppert, Ernest J. T. Luiten, Carmen C. van der Pol, Sanaz Samiei, Johannes H.W. de Wilt, +2 more
44citations -
Intraoperative Molecular Fluorescence Imaging of Pancreatic Cancer by Targeting Vascular Endothelial Growth Factor: A Multicenter Feasibility Dose-Escalation Study2022 Journal of Nuclear Medicine article Medicine Optical Imaging and Spectroscopy Techniques Open access
Babs G. Sibinga Mulder, Marjory Koller, Evelien W. Duiker, Arantza Fariña Sarasqueta, Jakobus Burggraaf, Vincent Erwin de Meijer, +6 more
35citations -
Safety and tumour-specific immunological responses of combined dendritic cell vaccination and anti-CD40 agonistic antibody treatment for patients with metastatic pancreatic cancer: protocol for a phase I, open-label, single-arm, dose-escalation study (REACtiVe-2 trial)
Sai Ping Lau, Freek R. van ‘t Land, Sjoerd H. van der Burg, Marjolein Y.V. Homs, Martijn P. Lolkema, Joachim G.J.V. Aerts, +1 more
9citations -
Impact of Partial- to Full-Support Escalation With Microaxial Flow Pumps Prior to Durable Left Ventricular Assist Device Implantation2026 European Journal of Cardio-Thoracic Surgery article Engineering Mechanical Circulatory Support Devices
Daniel Lewin, Gaik Nersesian, Sebastian V Rojas, Marina Pieri, Mariusz K. Szymanski, Janajade Kooij, +18 more
2citations -
Ripretinib intrapatient dose escalation after disease progression provides clinically meaningful outcomes in advanced gastrointestinal stromal tumour2021 European Journal of Cancer article Medicine Gastrointestinal Tumor Research and Treatment Open access
Suzanne George, Ping Chi, Michael Charles Heinrich, Margaret von Mehren, Robin L. Jones, Kristen N. Ganjoo, +11 more
31citations -
Serum N-Glycomic Biomarkers Predict Treatment Escalation in Inflammatory Bowel Disease2023 Journal of Crohn s and Colitis article Biochemistry, Genetics and Molecular Biology Inflammatory Bowel Disease Open access
Archana Shubhakar, Bas C. Jansen, Alex T. Adams, Karli R. Reiding, Nicholas T. Ventham, Rahul Kalla, +8 more
20citations -
A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti–PD-1 antibody, in patients with advanced solid tumors2020 Journal for ImmunoTherapy of Cancer article Medicine Cancer Immunotherapy and Biomarkers Open access cited by 1 patent
Aung Naing, Justin F. Gainor, Hans A. J. Gelderblom, Patrick M. Forde, Marcus Otho Butler, Chia‐Chi Lin, +11 more
86citations