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Mechanistic Investigations of Metallo-β-Lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition2020 ChemRxiv preprint Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Nicola Wade, Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Matthijs J. van Haren, Vida Mashayekhi, Nathaniel I. Martin
0citations -
Mechanistic Investigations of Metallo-β-Lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition2020 ChemRxiv preprint Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Nicola Wade, Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Matthijs J. van Haren, Vida Mashayekhi, Nathaniel I. Martin
1citations -
Methyl substituted β –lactam framework based antibiotics and β -lactamase inhibitors: Proof of concept by computations2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Chemistry Synthesis of β-Lactam Compounds Open access
Vaishali Thakkur, Chandan Kumar Das, Shivani Verma, Suman Saha, Nisanth N. Nair
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High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-specific Protease USP182025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Chemical Synthesis and Analysis Open access
Raymond Kooij, Vito Pol, Bjorn R. van Doodewaerd, Ayşegül Sapmaz, Günter Fritz, Klaus‐Peter Knobeloch, +1 more
2citations -
An Enhanced Sampling Approach to the Induced Fit Docking Problem in Protein-Ligand Binding: the case of mono-ADP-ribosylation hydrolases inhibitors2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Protein Structure and Dynamics Open access
Qianqian Zhao, Riccardo Capelli, Paolo Carloni, Bernhard Lüscher, Jinyu Li, Giulia Rossetti
1citations -
Tuning inhibitor susceptibility of human 4-hydroxyphenylpyruvate dioxygenase to rescue tyrosine catabolism in the presence of β-triketones2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access
Jessie Neuckermans, Alan Mertens, Sien Lequeue, Nina Stefanie Salvi, Liesbeth Desmet, Gigly G. Del’haye, +4 more
0citations -
Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine SARS-CoV-2 and COVID-19 Research Open access
Irene Georgiou, Colin Robinson, Sean N. O’Byrne, Alex Matsuda, Przemysław Grygier, Shamshad Ahmad, +17 more
1citations -
Tau phosphorylated at serine 356 is associated with Alzheimer’s disease pathology and can be lowered in mouse and human brain tissue using the NUAK inhibitor WZ40032023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Alzheimer's disease research and treatments Open access
Lewis W. Taylor, Elizabeth M. Simzer, Claire Pimblett, Oscar T. T. Lacey-Solymar, Robert I. McGeachan, Jamie L. Rose, +10 more
2citations -
6′,6′-Difluoro-aristeromycin is a potent inhibitor of MERS-coronavirus replication2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine SARS-CoV-2 and COVID-19 Research Open access
Natacha S. Ogando, Jessika C. Zevenhoven-Dobbe, Dnyandev B. Jarhad, Sushil Tripathi, Hyuk Woo Lee, Lak Shin Jeong, +2 more
2citations -
Huib32: A Potent and Selective USP32 Inhibitor Modulating Endosomal Processes and Advancing Cell-Permeable USP32 Probes2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access
Stephan Scherpe, Vito Pol, Raymond Kooij, Adán Pinto-Fernández, Rayman T.N. Tjokrodirijo, Darragh Patrick O'Brien, +6 more
1citations -
Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of IMP Type Metallo-β-Lactamases2020 ChemRxiv preprint Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Kamaleddin H. M. E. Tehrani, Nicola Wade, Vida Mashayekhi, Nora C. Brüchle, Willem Jespers, Koen Voskuil, +4 more
0citations -
Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of IMP Type Metallo-β-Lactamases2020 ChemRxiv preprint Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access
Kamaleddin H. M. E. Tehrani, Nicola Wade, Vida Mashayekhi, Nora C. Brüchle, Willem Jespers, Koen Voskuil, +4 more
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Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases2024 eLife preprint Biochemistry, Genetics and Molecular Biology ATP Synthase and ATPases Research Open access
Jianing Liu, Anokhi Shah, Yue Ma, Katie Hardman, Niklas G. Johansson, Orquídea Ribeiro, +8 more
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Functional Differentiation of GH172 Arabinofuranosidases Through Divergent Quaternary Structures2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Materials Science Enzyme Structure and Function Open access
Jennifer Ross, Moescha Hoopman, Florian Küllmer, Omar Al-Jourani, Augustinas Silale, Morwan M. Osman, +17 more
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In-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Protease and Inhibitor Mechanisms Open access
Bart Claushuis, Robert A. Cordfunke, Arnoud H. de Ru, Annemarie M. Otte, Hans C. van Leeuwen, Oleg I. Klychnikov, +4 more
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[1,2,4]Triazolo[3,4- b ]benzothiazole scaffold as versatile nicotinamide mimic allowing nanomolar inhibition of different PARP enzymes2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine PARP inhibition in cancer therapy Open access
Sudarshan Murthy, Maria Giulia Nizi, Mirko M. Maksimainen, Serena Massari, Juho Alaviuhkola, Barbara E. Lippok, +11 more
0citations -
Spatially resolved mapping of monoacylglycerol lipase activity in the brain2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cannabis and Cannabinoid Research Open access
Daan van der Vliet, Alex X.Y. Klinkenberg, Rik Platte, Kieran P. Higgins, Susanne Prokop, Mirjam C. W. Huizenga, +8 more
0citations -
Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases2024 eLife preprint Biochemistry, Genetics and Molecular Biology ATP Synthase and ATPases Research Open access
Jianing Liu, Anokhi Shah, Xinyu Liu, Joshua L. Wort, Yue Ma, Katie Hardman, +9 more
2citations -
Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases2025 eLife preprint Biochemistry, Genetics and Molecular Biology ATP Synthase and ATPases Research Open access
Jianing Liu, Anokhi Shah, Xinyu Liu, Joshua L. Wort, Yue Ma, Katie Hardman, +10 more
0citations -
Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Genetic Neurodegenerative Diseases Open access
Michael A. Margreiter, Monika Witzenberger, Yasmine Wasser, Elena Davydova, Robert Janowski, Carina Sobisch, +11 more
0citations