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Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4 , P‐gp, and CYP2D6 drug–drug–gene interaction network2023 CPT Pharmacometrics & Systems Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Denise Feick, Simeon Rüdesheim, Fatima Zahra Marok, Dominik Selzer, Helena Leonie Hanae Loer, Donato Teutonico, +6 more
12citations -
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance2023 Proceedings of the National Academy of Sciences article Medicine Tuberculosis Research and Epidemiology Open access
M. Alexandra Lake, Kristin N. Adams, Feilin Nie, Elaine Fowler, Amit Kumar Verma, Silvia Dei, +6 more
33citations -
Simulation-based assessment of the P-glycoprotein expression-activity relationship shows a drug and system dependency2026 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Daan W. van Valkengoed, Vivi Rottschäfer, Elizabeth C. M. de Lange
2citations -
Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance2025 Proceedings of the National Academy of Sciences article Medicine Tuberculosis Research and Epidemiology Open access
Adam J. Fountain, Jan Böhning, Stephen H. McLaughlin, Tomos E. Morgan, Paul H. Edelstein, Mark A. Troll, +4 more
7citations -
Effect of Cellular and Microenvironmental Multidrug Resistance on Tumor-Targeted Drug Delivery in Triple-Negative Breast cancer2023 Journal of Controlled Release article Materials Science Nanoparticle-Based Drug Delivery Open access
Okan Tezcan, Asmaa Said Elshafei, Karina Benderski, Elena Rama, Maike Wagner, Diana Moeckel, +8 more
23citations -
Changes in Protein Expression of Renal Drug Transporters and Drug‐Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients2025 Clinical Pharmacology & Therapeutics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Annika C. Tillmann, Dorien J.M. Peters, Amin Rostami‐Hodjegan, Patricia D. Wilson, Jill T. Norman, Jill Barber, +1 more
1citations -
Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?2025 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Berfin Gülave, Ariel Lesmana, Elizabeth C. M. de Lange, J. G. Coen van Hasselt
4citations -
Mapping cardiac drug transport: In vitro assessment of cardiac P-glycoprotein function with [18F]MC225 by using µ-engineered heart tissues2025 European Heart Journal Open article Medicine Drug Transport and Resistance Mechanisms Open access
Wanling Liu, Maureen Dannenberg, Pascalle Mossel, Zeyu Cai, Ines Farinha Antunes, Jürgen W. A. Sijbesma, +7 more
1citations -
Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily2024 Frontiers in Pharmacology article Medicine Drug Transport and Resistance Mechanisms Open access
Daniela Digles, Álvaro Inglés‐Prieto, Vojtech Dvorak, Tamara A. M. Mocking, Ulrich Goldmann, Andrea Garofoli, +28 more
12citations -
Should we abandon therapeutic drug monitoring of tacrolimus in whole blood and move to intracellular concentration measurements?2023 British Journal of Clinical Pharmacology article Medicine Renal Transplantation Outcomes and Treatments Open access
Suwasin Udomkarnjananun, Thanee Eiamsitrakoon, Brenda C. M. de Winter, Teun van Gelder, Dennis Alexander Hesselink
19citations -
A New ABCB1 Inhibitor Enhances the Anticancer Effect of Doxorubicin in Both In Vitro and In Vivo Models of NSCLC2023 International Journal of Molecular Sciences article Medicine Drug Transport and Resistance Mechanisms Open access
Maria Pia Adorni, Maricla Galetti, Silvia La Monica, Matteo Incerti, Alessandro Ruffoni, Lisa Elviri, +6 more
16citations -
Extrahepatic metabolism of ibrutinib2020 Investigational New Drugs article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Johannes J.M. Rood, Amer Jamalpoor, Stéphanie van Hoppe, Matthijs J. van Haren, Roeland E. Wasmann, Manoe Jacoba Janssen, +4 more
28citations -
ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells2024 Journal of Experimental & Clinical Cancer Research article Medicine Drug Transport and Resistance Mechanisms Open access
Cecilia Bergonzini, Alessandro Gregori, Tessa M. S. Hagens, Vera E. van der Noord, Bob van de Water, Annelien J.M. Zweemer, +10 more
38citations -
Exploratory Study of Sex Differences in P‐Glycoprotein Function at the Blood–Brain Barrier2025 Clinical and Translational Science article Medicine Drug Transport and Resistance Mechanisms Open access
Giordana Salvi de Souza, Wanling Liu, Pascalle Mossel, Joost F. Somsen, Anna L. Bartels, Cristiane Regina Guerino Furini, +3 more
7citations -
Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport2024 European Journal of Pharmaceutical Sciences article Neuroscience Barrier Structure and Function Studies Open access
Mengxu Zhang, Ilona M. Vuist, Vivi Rottschäfer, Elizabeth C. M. de Lange
3citations