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Distinct Effects of Inflammation on Cytochrome P450 Regulation and Drug Metabolism: Lessons from Experimental Models and a Potential Role for Pharmacogenetics2020 Genes article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Laura M. de Jong, Wim Jiskoot, Jesse Joachim Swen, Martijn L. Manson
122citations -
Association of Polymorphic Cytochrome P450 Enzyme Pathways with Falls in Multimedicated Older Adults2024 Journal of the American Medical Directors Association article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Katja Susanne Just, Laura M. Pott, Catharina Scholl, Michael Steffens, Michael Dieter Denkinger, Dietrich Rothenbacher, +2 more
4citations -
Nanoscopic visualization of microgel-immobilized cytochrome P450 enzymes and their local activity2024 Nanoscale article Biochemistry, Genetics and Molecular Biology Advanced Fluorescence Microscopy Techniques Open access
Lukas Schubert, Chiara Nenninger, Maximilian Nöth, Thomke Belthle, Robert Dirk de Lange, Andrij Pich, +2 more
3citations -
MicroGelzymes: pH-Independent Immobilization of Cytochrome P450 BM3 in Microgels2020 Biomacromolecules article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization
Maximilian Nöth, Larissa Hussmann, Thomke Belthle, Islam El‐Awaad, Mehdi D. Davari, Felix Jakob, +2 more
38citations -
Flexibility Regulation of Loops Surrounding the Tunnel Entrance in Cytochrome P450 Enhanced Substrate Access Substantially2022 ACS Catalysis article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization
Zhongyu Li, Shuaiqi Meng, Kaili Nie, Ulrich Schwaneberg, Mehdi D. Davari, Haijun Xu, +2 more
80citations -
Preparative‐Scale Production of Testosterone Metabolites by Human Liver Cytochrome P450 Enzyme 3A42020 Advanced Synthesis & Catalysis article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Nico D. Fessner, Matic Srdič, Hansjörg Weber, Christian Schmid, David Schönauer, Ulrich Schwaneberg, +1 more
20citations -
Preparative Production of Functionalized (N- and O-Heterocyclic) Polycyclic Aromatic Hydrocarbons by Human Cytochrome P450 3A4 in a Bioreactor2022 Biomolecules article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access
Matic Srdič, Nico D. Fessner, Deniz Yıldız, Anton Glieder, Markus Spiertz, Ulrich Schwaneberg
7citations -
Uncoupling of Cytochrome P450 2B6 and stimulation of reactive oxygen species production in pharmacogenomic alleles affected by interethnic variability2024 Biochimica et Biophysica Acta (BBA) - General Subjects article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Sabrina Yamoune, Julian Peter Müller, Immaculate Mbongo Langmia, Catharina Scholl, Julia Stingl
10citations -
Unraveling the Effects of Acute Inflammation on Pharmacokinetics: A Model-Based Analysis Focusing on Renal Glomerular Filtration Rate and Cytochrome P450 3A4-Mediated Metabolism2023 European Journal of Drug Metabolism and Pharmacokinetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Feiyan Liu, Linda B. S. Aulin, Martijn L. Manson, Elke H. J. Krekels, J. G. Coen van Hasselt
9citations -
Assessment of Substrate Status of Drugs Metabolized by Polymorphic Cytochrome P450 (CYP) 2 Enzymes: An Analysis of a Large-Scale Dataset2024 Biomedicines article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Justyna Wozniak, Judith Schmitt, Jana Koch, Julia Stingl, Katja Susanne Just
6citations -
Impact of steroid hormone levels on estradiol‐mediated regulation of cytochrome P450 2B6 compared to 1B1 in breast cancer cells2024 Basic & Clinical Pharmacology & Toxicology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Marco Hoffmann, Julian Peter Müller, Jochen Maurer, A. Folliot, Sabrina Yamoune, Julia Stingl
5citations -
Structural insights into the effects of glycerol on ligand binding to cytochrome P4502022 Acta Crystallographica Section D Structural Biology article Materials Science Enzyme Structure and Function
Sergey S. Bukhdruker, Tatsiana Varaksa, Philipp S. Orekhov, Irina P. Grabovec, Egor Marin, Ivan Kapranov, +10 more
4citations -
Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment2021 Basic & Clinical Pharmacology & Toxicology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Sabrina Yamoune, Katharina Wintz, Christian Niederau, Rogerio Bastos Craveiro, Michael F. Wolf, Julia Stingl
7citations -
Evaluation of stabilizing additives to protect activities of cytochrome P450 enzymes for in vitro drug testing and pharmacogenetic studies: Focus on CYP2D62025 Biochimica et Biophysica Acta (BBA) - General Subjects article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism
Sabrina Yamoune, Henner Koch, Daniel Delev, Yvonne G. Weber, Julia Stingl
4citations -
CYP P450 and non-CYP P450 Drug Metabolizing Enzyme Families Exhibit Differential Sensitivities towards Proinflammatory Cytokine Modulation2024 Drug Metabolism and Disposition article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Laura M. de Jong, Chandan Harpal, Dirk‐Jan van den Berg, Menno Hoekstra, Nienke J Peter, Robert Rißmann, +2 more
11citations -
Global Dynamic Design (GDD) Empowers Cytochrome P450s for Improved Catalytic Performance2025 ACS Sustainable Chemistry & Engineering article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization
Shuaiqi Meng, Yu Ji, Peng Zhang, Binbin Nian, Chenba Zhu, Mehdi D. Davari, +3 more
2citations -
Modulating the Coupling Efficiency of P450 BM3 by Controlling Water Diffusion through Access Tunnel Engineering2021 ChemSusChem article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization Open access cited by 1 patent
Shuaiqi Meng, Yu Ji, Luo Liu, Mehdi D. Davari, Ulrich Schwaneberg
24citations -
Structural insights into 3Fe–4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P4502023 Frontiers in Molecular Biosciences article Materials Science Enzyme Structure and Function Open access
Andrei A. Gilep, Tatsiana Varaksa, Sergey S. Bukhdruker, Anton Kavaleuski, Yury L. Ryzhykau, Sviatlana V. Smolskaya, +17 more
13citations -
The molecular basis and enzyme engineering strategies for improvement of coupling efficiency in cytochrome P450s2022 Biotechnology Advances article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization
Shuaiqi Meng, Yu Ji, Leilei Zhu, Gaurao V. Dhoke, Mehdi D. Davari, Ulrich Schwaneberg
49citations -
Introduction of aromatic amino acids in electron transfer pathways yielded improved catalytic performance of cytochrome P450s2023 CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION) article Chemistry Metal-Catalyzed Oxygenation Mechanisms
Shuaiqi Meng, Zhongyu Li, Yu Ji, Anna Joëlle Ruff, Luo Liu, Mehdi D. Davari, +1 more
39citations