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Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches2024 Seminars in Immunology article Immunology and Microbiology Complement system in diseases Open access
Vitalijs Ovcinnikovs, Karin Dijkman, Gijs G. Zom, Frank J M Beurskens, Leendert Adrianus Trouw
18citations -
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation2024 Journal of the American Chemical Society article Immunology and Microbiology Complement system in diseases Open access
Leoni Abendstein, Willem E. M. Noteborn, Luc S. Veenman, Douwe J. Dijkstra, Fleur S. van de Bovenkamp, Leendert Adrianus Trouw, +1 more
16citations -
Complement Activation Levels Are Related to Disease Stage in AMD2020 Investigative Ophthalmology & Visual Science article Medicine Retinal Diseases and Treatments Open access
Thomas J. Heesterbeek, Yara T. E. Lechanteur, Laura Lorés‐Motta, Tina Schick, Mohamed R. Daha, Lebriz Altay, +6 more
79citations -
Lectin and alternative complement pathway activation in cutaneous manifestations of IgA-vasculitis: A new target for therapy?2022 Molecular Immunology article Immunology and Microbiology Complement system in diseases Open access
Jeffrey J. Damman, Antien L. Mooyaart, Thierry P. P. van den Bosch, Marc A. Seelen, Martijn B. van Doorn
20citations -
Thrombospondin-1 inhibits alternative complement pathway activation in vasculitis synergistically to factor H2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Complement system in diseases Open access
Swagata Konwar, Sophie Schroda, Jessika Kleindienst, Eva L. Decker, Martin Pohl, Barbara Zieger, +10 more
0citations -
DNA nanostructure-templated antibody complexes provide insights into the geometric requirements of human complement cascade activation2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Complement system in diseases Open access
Leoni Abendstein, Willem E. M. Noteborn, Luc S. Veenman, Douwe J. Dijkstra, Fleur S. van de Bovenkamp, Leendert Adrianus Trouw, +1 more
0citations -
C1q-targeting bispecific antibodies bypass Fc to trigger complement activation and receptor clustering agonism2026 Molecular Immunology article Medicine Monoclonal and Polyclonal Antibodies Research Open access
Douwe J. Dijkstra, Marfa Blanter, Els van der Meijden, Rick J. Groenland, Clifford Rodriguez, Boris Bleijlevens, +2 more
0citations -
Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Biomarkers in Disease Mechanisms Open access
Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers, Mariska E. Keizer, Jip Wulffelé, Tijn T. van der Velden, +4 more
3citations -
Systemic and local complement activation in peritoneal dialysis patients via conceivably distinct pathways2023 Peritoneal Dialysis International article Immunology and Microbiology Complement system in diseases Open access
Bernardo Faria, Mariana Gaya da Costa, Stefan P. Berger, Carla Lima, Cátia Pêgo, Jacob van den Born, +5 more
1citations -
Complement Activation is More Pronounced in the Kidneys of Critically Ill Patients With COVID-19 Than in Those With Bacterial Sepsis2025 Kidney International Reports article Immunology and Microbiology Complement system in diseases Open access
Firas Farisi Alkaff, Grietje G Talen, Marius Christianus van den Heuvel, Meint Volbeda, Matijs van Meurs, Jill Moser, +3 more
1citations -
Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein2024 Proceedings of the National Academy of Sciences article Immunology and Microbiology Biomarkers in Disease Mechanisms Open access
Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers, Mariska E. Keizer, Jip Wulffelé, Tijn T. van der Velden, +4 more
24citations -
Complement activation in secondary thrombotic microangiopathies2025 Nephrology Dialysis Transplantation article Immunology and Microbiology Complement system in diseases Open access
Johann Morelle, Fernando Caravaca‐Fontán, Fádi Fakhouri, Eleni A. Frangou, Annette N. Bruchfeld, Jürgen Floege, +9 more
18citations -
Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids2023 Frontiers in Immunology article Immunology and Microbiology Complement system in diseases Open access
Lonneke H. Gaykema, Rianne Y. van Nieuwland, Mette C. Dekkers, Mieke F. van Essen, Sebastiaan Heidt, Arnaud Zaldumbide, +3 more
17citations -
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation2024 The Journal of Immunology article Immunology and Microbiology Complement system in diseases Open access
Sebastiaan M. W. R. Hamers, Aimee L. Boyle, Thomas Harry Sharp
5citations