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Towards biomarkers for outcomes after pancreatic ductal adenocarcinoma and ischemic stroke, with focus on (co-)morbidity and aging / cellular senescence (SASKit): protocol for a prospective cohort study
Larissa Henze, Uwe Walter, Hugo Murua Escobar, Christian Junghanß, Robert Jaster, Rüdiger Köhling, +9 more
0citations -
Vascular niches are the primary hotspots for aging within the multicellular architecture of cardiac tissue2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Cardiac Fibrosis and Remodeling Open access
David Rodríguez Morales, Veronica Larcher, Mariano Ruz Jurado, Lukas Stefan Tombor, Lukas Zanders, Julian U. G. Wagner, +5 more
0citations -
Loss of nuclear-cytoplasmic compartmentalization is a hallmark of aging in podocytes2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Nuclear Structure and Function
Mohamed Hamed, Yingying Gao, Frank Stein, Grishal Vijay, Thilo Stausberg, Ramona Jühlen, +6 more
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Protracted fate acquisition and epigenetic de-aging during induced neural stem cell conversion of human blood cells2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access
Lea Jessica Berg, Julia Franzen, Andreas Buneß, Rachel Konang, Chao Sheng, Michael Peitz, +3 more
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Microvesicle-Mediated Tissue Regeneration Mitigates the Effects of Cellular Ageing2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Extracellular vesicles in disease Open access
Dagmara McGuiness, Armand M. G. Jaminon, Barend M.E. Mees, Colin Selman, Leon J. Schurgers, Paul G. Shiels
0citations -
Rewired type I IFN signaling is linked to age-dependent differences in COVID-192024 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology interferon and immune responses Open access
Sophia Brumhard, Sebastian Wisniewski, Philipp Georg, David Hillus, Anna Luisa Hiller, Rosario Astaburuaga-García, +25 more
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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Hematopoietic Stem Cell Transplantation Open access
Jos H. M. Urbanus, Jason Cosgrove, Joost B. Beltman, Yuval Elhanati, Rafael de Andrade Moral, Cécile Conrad, +13 more
1citations -
Degradation Analysis of 18650 Cylindrical Cell Battery Pack with Immersion Liquid Cooling System. Part 2: Aging Assessment at Cell Level2024 SSRN Electronic Journal preprint Engineering Advanced Battery Technologies Research Open access
Timo Rüwald, Hedi van Faassen, Heinrich Ditler, Darya Chahardahcherik, Dominik Schulte, Egbert Figgemeier
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Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages2022 Research Square preprint Biochemistry, Genetics and Molecular Biology Single-cell and spatial transcriptomics Open access
Amirhossein Modabbernia, Didac Vidal‐Piñeiro, Ingrid Agartz, Ole A. Andreassen, Rosa Ayesa‐Arriola, Alessandro Bertolino, +67 more
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Plasma triacylglycerol length and saturation level mark healthy aging groups in humans2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Lipid metabolism and biosynthesis Open access
Weisha Li, Bauke V. Schomakers, Michel van Weeghel, Lotte Grevendonk, Frédéric Maxime Vaz, Gajja Sophi Salomons, +5 more
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Evaluation of B-Cell Kinetics After Acellular Pertussis Vaccination in Four Cohorts of Different Age and Priming Background2021 Preprints.org preprint Immunology and Microbiology Bacterial Infections and Vaccines Open access
Annieck M. Diks, Pauline Versteegen, Cristina Teodósio, Rick J. Groenland, Bas de Mooij, Anne‐Marie Buisman, +6 more
1citations -
Multimodal evidence for impaired glymphatic brain clearance as a mediator of “inflammaging” in schizophrenia – integrating insights from in vivo neuroimaging, omics, and post-mortem single nucleus-RNA-Seq data2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Cerebrospinal fluid and hydrocephalus Open access
Xiaolin Tan, Malte Simon, Daniel Rosebrock, Mariia M Firulyova, Doris Gruber-Schoffnegger, Marisa Fuerst, +7 more
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Reversing PROTAC-induced ASH2L degradation reactivates proliferation in senescent cells2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Protein Degradation and Inhibitors Open access
Janina Müller, Mirna Barsoum, Philip Bussmann, Mohamed H. Elsafi Mabrouk, Roksaneh Sayadi-Boroujeni, Anna-Maria Vllaho, +6 more
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Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Genetics, Aging, and Longevity in Model Organisms Open access
Pasquale C. Putter, Di Guan, Thies Gehrmann, Daniel Kolbe, Jiping Yang, HyeRim Han, +13 more
2citations -
Omics studies of nuclear protein aggregates in subcellular fractions reveals co- aggregation of RNA-binding proteins affecting cytosolic pathways2025 Research Square preprint Biochemistry, Genetics and Molecular Biology RNA Research and Splicing Open access
Milad Shademan, Sarah E. Flannery, Erik Bos, Tom M. J. Evers, Vahid Sheikhhassani, Alireza Mashaghi, +5 more
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A combined lifestyle intervention induces a sensitization of the blood transcriptomic response to a nutrient challenge2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Nutrition, Genetics, and Disease Open access
Thies Gehrmann, Marian Beekman, Joris Deelen, Linda Partridge, Ondine van de Rest, Leon Mei, +6 more
5citations -
Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Telomeres, Telomerase, and Senescence Open access
Spiros Palikyras, Konstantinos Sofiadis, Athanasia Stavropoulou, Adi Danieli‐Mackay, Vassiliki Varamogianni‐Mamatsi, David Hörl, +15 more
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Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Genetics, Aging, and Longevity in Model Organisms Open access
Gwendoline Astre, Tehila Atlan, Uri Goshtchevsky, Kobi Shapira, Adi Oron-Gottesman, Tomer Levy, +5 more
9citations -
Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Glioma Diagnosis and Treatment Open access
Vidhya Madapusi Ravi, Paulina Will, Jan Kueckelhaus, Na Sun, Kevin Joseph, Henrike Salié, +20 more
12citations -
Immunogenicity and protective efficacy of one- and two-dose regimens of the Ad26.COV2.S COVID-19 vaccine candidate in adult and aged rhesus macaques2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine SARS-CoV-2 and COVID-19 Research Open access
Laura Solforosi, Harmjan Kuipers, Sietske K. Rosendahl Huber, Joan E. M. van der Lubbe, Liesbeth Dekking, Dominika N. Czapska-Casey, +31 more
10citations