Papers matching “brain extracellular fluid” 25
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Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations2021 Journal of Pharmacokinetics and Pharmacodynamics article Neuroscience Barrier Structure and Function Studies Open access
Mohammed A. A. Saleh, Chi Fong Loo, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
43citations -
Do Brain Extracellular Fluid Concentrations Predict PET ‐Inferred Receptor Occupancy in Human CNS ? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands2026 Clinical Pharmacology & Therapeutics article Neuroscience Neurotransmitter Receptor Influence on Behavior Open access
Divakar Budda, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
0citations -
Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice2023 Pharmaceutical Research article Neuroscience Barrier Structure and Function Studies Open access
Mohammed A. A. Saleh, Berfin Gülave, Olivia Campagne, Clinton F. Stewart, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
5citations -
Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?2025 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Daan W. van Valkengoed, Makoto Hirasawa, Vivi Rottschäfer, Elizabeth C. M. de Lange
5citations -
Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport2024 European Journal of Pharmaceutical Sciences article Neuroscience Barrier Structure and Function Studies Open access
Mengxu Zhang, Ilona M. Vuist, Vivi Rottschäfer, Elizabeth C. M. de Lange
3citations -
Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model2022 Pharmaceutical Research article Medicine Cholinesterase and Neurodegenerative Diseases Open access
Mohammed A. A. Saleh, Julia S. Bloemberg, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
8citations -
Mass spectrometry based metabolomics of volume-restricted in-vivo brain samples: Actual status and the way forward2021 TrAC Trends in Analytical Chemistry article Biochemistry, Genetics and Molecular Biology Metabolomics and Mass Spectrometry Studies Open access
Marlien van Mever, Karen Segers, Debby Mangelings, Thomas Hankemeier, Yvan Vander Heyden, Ann Van Eeckhaut, +1 more
9citations -
Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?2025 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Berfin Gülave, Ariel Lesmana, Elizabeth C. M. de Lange, J. G. Coen van Hasselt
4citations -
The Extension of the LeiCNS-PK3.0 Model in Combination with the “Handshake” Approach to Understand Brain Tumor Pathophysiology2022 Pharmaceutical Research article Neuroscience Barrier Structure and Function Studies Open access
Makoto Hirasawa, Mohammed A. A. Saleh, Elizabeth C. M. de Lange
7citations -
LeiCNS-PK3.2: A physiologically based pharmacokinetic model framework for predicting intracellular concentrations of acyclovir and ganciclovir active metabolites2026 European Journal of Pharmaceutical Sciences article Medicine Drug Transport and Resistance Mechanisms Open access
Ming Sun, Martijn L. Manson, Tingjie Guo, Elizabeth C. M. de Lange
1citations -
Application of the LeiCNS-PK model to quantitatively evaluate the roles of BBB active influx and brain metabolism of fluvoxamine and its serotonin transporter (SERT) occupancy in rat and human0citations
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The PBPK LeiCNS-PK3.0 framework predicts Nirmatrelvir (but not Remdesivir or Molnupiravir) to achieve effective concentrations against SARS-CoV-2 in human brain cells2022 European Journal of Pharmaceutical Sciences article Medicine SARS-CoV-2 and COVID-19 Research Open access
Mohammed A. A. Saleh, Makoto Hirasawa, Ming Sun, Berfin Gülave, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
10citations -
Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?2023 European Journal of Pharmaceutical Sciences article Medicine Pain Management and Opioid Use Open access
Berfin Gülave, Divakar Budda, Mohammed A. A. Saleh, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
4citations -
Toward optimal moxifloxacin dosing in tuberculous meningitis: A translational physiologically based pharmacokinetic modeling approach2026 European Journal of Pharmaceutical Sciences article Medicine Antibiotics Pharmacokinetics and Efficacy Open access
Ming Sun, Katie Lynch, Theis Mariager, Jacob Bodilsen, Roland Nau, Rob Christiaan van Wijk, +2 more
0citations -
The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D 2 receptor occupancy in humans2026 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Mengxu Zhang, Thomas I.F.H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange
0citations -
Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system2021 Brain Communications article Biochemistry, Genetics and Molecular Biology Extracellular vesicles in disease Open access cited by 1 patent
Marina Sogorb-González, Carlos Vendrell‐Tornero, Jolanda Snapper, Anouk Stam, Sonay Keskin, Jana Miniarikova, +7 more
6citations -
Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis2025 European Journal of Pharmaceutical Sciences article Neuroscience Neuropeptides and Animal Physiology Open access
Divakar Budda, Zhicheng Zhang, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
5citations
25 results