Papers matching “brain extracellular fluid” 33
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Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations2021 Journal of Pharmacokinetics and Pharmacodynamics article Neuroscience Barrier Structure and Function Studies Open access
Mohammed A. A. Saleh, Chi Fong Loo, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
43citations -
Do Brain Extracellular Fluid Concentrations Predict PET ‐Inferred Receptor Occupancy in Human CNS ? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands2026 Clinical Pharmacology & Therapeutics article Neuroscience Neurotransmitter Receptor Influence on Behavior Open access
Divakar Budda, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
0citations -
Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice2023 Pharmaceutical Research article Neuroscience Barrier Structure and Function Studies Open access
Mohammed A. A. Saleh, Berfin Gülave, Olivia Campagne, Clinton F. Stewart, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
5citations -
Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?2025 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Daan W. van Valkengoed, Makoto Hirasawa, Vivi Rottschäfer, Elizabeth C. M. de Lange
5citations -
Role of extracellular vesicle-carried ncRNAs in the interactive ‘dialogue’ within the brain and beyond: emerging theranostic epigenetic modifiers in brain-derived nanoplatforms2025 Translational Neurodegeneration article Biochemistry, Genetics and Molecular Biology Extracellular vesicles in disease Open access
Nima Sanadgol, Pegah Mousavi, Fatemeh Sadri, Clara Voelz, Miriam Scheld, Roghayeh Khalseh, +5 more
9citations -
Exploring Kp,uu,BBB Values Smaller than Unity in Remoxipride: A Physiologically-Based CNS Model Approach Highlighting Brain Metabolism in Drugs with Passive Blood-Brain Barrier Transport2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Barrier Structure and Function Studies Open access
Mengxu Zhang, Ilona M. Vuist, Vivi Rottschäfer, Elizabeth C. M. de Lange
0citations -
Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport2024 European Journal of Pharmaceutical Sciences article Neuroscience Barrier Structure and Function Studies Open access
Mengxu Zhang, Ilona M. Vuist, Vivi Rottschäfer, Elizabeth C. M. de Lange
3citations -
Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model2022 Pharmaceutical Research article Medicine Cholinesterase and Neurodegenerative Diseases Open access
Mohammed A. A. Saleh, Julia S. Bloemberg, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
8citations -
Mass spectrometry based metabolomics of volume-restricted in-vivo brain samples: Actual status and the way forward2021 TrAC Trends in Analytical Chemistry article Biochemistry, Genetics and Molecular Biology Metabolomics and Mass Spectrometry Studies Open access
Marlien van Mever, Karen Segers, Debby Mangelings, Thomas Hankemeier, Yvan Vander Heyden, Ann Van Eeckhaut, +1 more
9citations -
Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?2025 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Berfin Gülave, Ariel Lesmana, Elizabeth C. M. de Lange, J. G. Coen van Hasselt
4citations -
The Extension of the LeiCNS-PK3.0 Model in Combination with the “Handshake” Approach to Understand Brain Tumor Pathophysiology2022 Pharmaceutical Research article Neuroscience Barrier Structure and Function Studies Open access
Makoto Hirasawa, Mohammed A. A. Saleh, Elizabeth C. M. de Lange
7citations -
LeiCNS-PK3.2: A physiologically based pharmacokinetic model framework for predicting intracellular concentrations of acyclovir and ganciclovir active metabolites2026 European Journal of Pharmaceutical Sciences article Medicine Drug Transport and Resistance Mechanisms Open access
Ming Sun, Martijn L. Manson, Tingjie Guo, Elizabeth C. M. de Lange
1citations -
Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Barrier Structure and Function Studies Open access
Berfin Gülave, Divakar Budda, Mohammed A. A. Saleh, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
0citations -
The PBPK LeiCNS-PK3.0 framework predicts Nirmatrelvir (but not Remdesivir or Molnupiravir) to achieve effective concentrations against SARS-CoV-2 in human brain cells2022 European Journal of Pharmaceutical Sciences article Medicine SARS-CoV-2 and COVID-19 Research Open access
Mohammed A. A. Saleh, Makoto Hirasawa, Ming Sun, Berfin Gülave, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
10citations -
Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?2023 European Journal of Pharmaceutical Sciences article Medicine Pain Management and Opioid Use Open access
Berfin Gülave, Divakar Budda, Mohammed A. A. Saleh, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
4citations