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Bioprocess in‐line monitoring using Raman spectroscopy and Indirect Hard Modeling (IHM): A simple calibration yields a robust model2023 Biotechnology and Bioengineering article Chemistry Spectroscopy and Chemometric Analyses Open access
David Heinrich Müller, Carsten Flake, Thorsten Brands, Hans‐Jürgen Koß
17citations -
Process Model Files for Manuscript under Consideration "Techno-Economic Modeling and Optimization of a Lignocellulosic Biorefinery for gamma-Valerolactone and 1,4-Pentanediol Production"
Kaan Rehwasser, Julian Nöhl, Alexander Walter Wilhelm Echtermeyer, Lukas Polte, Andreas Jupke, Pascal Albrecht, +3 more
0citations -
Process Model Files for Manuscript under Consideration "Techno-Economic Modeling and Optimization of a Lignocellulosic Biorefinery for gamma-Valerolactone and 1,4-Pentanediol Production"
Kaan Rehwasser, Julian Nöhl, Alexander Walter Wilhelm Echtermeyer, Lukas Polte, Andreas Jupke, Pascal Albrecht, +3 more
0citations -
estim8 - An FMI-compliant Python toolbox for bioprocess modeling and parameter estimation2026 The Journal of Open Source Software article Biochemistry, Genetics and Molecular Biology Viral Infectious Diseases and Gene Expression in Insects Open access
Tobias Latour, Michael Osthege, Wolfgang Wiechert, Stephan Noack
0citations -
pyFOOMB: Python framework for object oriented modeling of bioprocesses2021 Engineering in Life Sciences article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Johannes Hemmerich, Niklas Tenhaef, Wolfgang Wiechert, Stephan Noack
30citations -
COMPmodelpy: Understanding Microbial Metabolism in Bioreactors in a Compartment Modeling Framework2026 RWTH Publications (RWTH Aachen) conference-paper Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Samira van den Bogaard, Titania Insani Sugiarto, Tobias B. Alter, Lars M. Blank
0citations -
COMPmodelpy: Understanding Microbial Metabolism in Bioreactors in a Compartment Modeling Framework2026 Zenodo (CERN European Organization for Nuclear Research) article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Samira van den Bogaard, Titania Insani Sugiarto, Tobias B. Alter, Lars M. Blank
0citations -
Robotic integration enables autonomous operation of laboratory scale stirred tank bioreactors with model‐driven process analysis2021 Biotechnology and Bioengineering article Biochemistry, Genetics and Molecular Biology Viral Infectious Diseases and Gene Expression in Insects Open access
Holger Morschett, Niklas Tenhaef, Johannes Hemmerich, Laura Herbst, Markus Spiertz, Deniz Doğan, +3 more
16citations -
A dual-parameter identification approach for data-based predictive modeling of hybrid gene regulatory network-growth kinetics in Pseudomonas putida mt-22020 Bioprocess and Biosystems Engineering article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction
Argyro Tsipa, Jake Alan Pitt, Julio R. Banga, Athanasios Mantalaris
4citations -
Control of parallelized bioreactors II: probabilistic quantification of carboxylic acid reductase activity for bioprocess optimization2022 Bioprocess and Biosystems Engineering article Biochemistry, Genetics and Molecular Biology Viral Infectious Diseases and Gene Expression in Insects Open access
Nikolas von den Eichen, Michael Osthege, Lukas Bromig, Wolfgang Wiechert, Marco Oldiges, Dirk Weuster‐Botz
11citations -
Synthetic spectral libraries for Raman model calibration2025 Analytical and Bioanalytical Chemistry article Chemistry Spectroscopy and Chemometric Analyses Open access cited by 1 patent
Louis Hellequin, Vicent J. Borràs, Patrick Romann, Nandita Vishwanathan, Jonathan Souquet, Thomas K. Villiger
3citations -
pyFOOMB: Python Framework for Object Oriented Modelling of Bioprocesses2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Johannes Hemmerich, Niklas Tenhaef, Wolfgang Wiechert, Stephan Noack
3citations -
Explore or exploit? A model‐based screening strategy for PETase secretion by Corynebacterium glutamicum2022 Biotechnology and Bioengineering article Biochemistry, Genetics and Molecular Biology Viral Infectious Diseases and Gene Expression in Insects Open access
Laura M. Helleckes, Carolin Müller, Tim Griesbach, Vera Waffenschmidt, Matthias Moch, Michael Osthege, +2 more
22citations -
Online Process State Estimation for Hansenula polymorpha Cultivation with 2D Fluorescence Spectra-Based Chemometric Model Calibrated from a Theoretical Model in Place of Offline Measurements2023 Fermentation article Biochemistry, Genetics and Molecular Biology Viral Infectious Diseases and Gene Expression in Insects Open access
Majharulislam Babor, Olivier Paquet‐Durand, Christoph Berg, Jochen Büchs, Bernd Hitzmann
4citations -
Assessing the capabilities of 2D fluorescence monitoring in microtiter plates with data-driven modeling for secondary substrate limitation experiments of Hansenula polymorpha2023 Journal of Biological Engineering article Biochemistry, Genetics and Molecular Biology Viral Infectious Diseases and Gene Expression in Insects Open access
Christoph Berg, Laura Herbst, Lisa Gremm, Nina Ihling, Olivier Paquet‐Durand, Bernd Hitzmann, +1 more
3citations -
Computer-aided bioprocess and solvent design for industrial methyl ketone production2026 Chemical Engineering Journal article Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Henry Hilker, Lukas Raßpe-Lange, Lukas Polte, Anita L. Ziegler, Clemens Kortmann, Alexander Mitsos, +2 more
0citations -
Computer-Aided Bioprocess and Solvent Design for Industrial Methyl Ketone Production2026 ChemRxiv preprint Biochemistry, Genetics and Molecular Biology Microbial Metabolic Engineering and Bioproduction Open access
Henry Hilker, Lukas Raßpe-Lange, Lukas Polte, Anita L. Ziegler, Clemens Kortmann, Alexander Mitsos, +2 more
0citations -
Analysis across scales: Integrated insights in metabolism and economic feasibility of recombinant protein production from CO2 and H20citations
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Analysis across scales: Integrated insights in metabolism and economic feasibility of recombinant protein production from CO2 and H20citations