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Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells2023 Nature Cardiovascular Research article Immunology and Microbiology Atherosclerosis and Cardiovascular Diseases Open access
Marie A.C. Depuydt, Frank H. Schaftenaar, Koen H.M. Prange, Arjan Boltjes, Esmeralda Hemme, Lucie Delfos, +14 more
96citations -
Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus2020 Journal of Translational Autoimmunity article Immunology and Microbiology T-cell and B-cell Immunology Open access
Rachel Madley, Grace Nauman, Nichole M. Danzl, Chiara Borsotti, Mohsen Khosravi Maharlooei, Hao Wei Li, +5 more
22citations -
Targeting autoreactive B cells in rheumatoid arthritis through MHC class I-presented BCR-derived neo-epitopes2026 Journal of Autoimmunity article Biochemistry, Genetics and Molecular Biology vaccines and immunoinformatics approaches Open access
Renee van de Wetering, Arieke S. B. Kampstra, Michel G.D. Kester, Rayman T.N. Tjokrodirijo, Arnoud H. de Ru, Peter A. van Veelen, +3 more
0citations -
Cross-presentation of citrullinated antigens drives cytotoxic CD8 + T cell responses in rheumatoid arthritis2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Rheumatoid Arthritis Research and Therapies Open access
Jae‐Seung Moon, Mengrui Zhang, Laura S. van Dam, Eun Kyung Song, Orr Sharpe, Julie Carman, +6 more
0citations -
Increased Phosphorylation of Intracellular Signaling Molecules Indicates Continuous Activation of Human Autoreactive B‐Cells2025 European Journal of Immunology article Immunology and Microbiology T-cell and B-cell Immunology Open access
Sanne Kroos, Nienke J. Blomberg, Joanneke C. Kwekkeboom, Rudi W. Hendriks, Odilia B. J. Corneth, René E. M. Toes, +1 more
4citations -
Autoreactive B cells in rheumatoid arthritis consist of activated CXCR3+ memory B cells and plasmablasts2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Rheumatoid Arthritis Research and Therapies Open access
Sanne Reijm, Joanneke C. Kwekkeboom, Nienke J. Blomberg, Jolien Suurmond, Diane van der Woude, René E. M. Toes, +1 more
1citations -
Tissue-resident memory T cells in human kidney transplants have alloreactive potential2024 American Journal of Transplantation article Medicine Renal Transplantation Outcomes and Treatments Open access
Daphne M Hullegie-Peelen, Hector Tejeda Mora, Sebastiaan Heidt, Eric M. Bindels, Martin Johannes Hoogduijn, Dennis Alexander Hesselink, +1 more
4citations -
Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis2020 Science Translational Medicine article Medicine Rheumatoid Arthritis Research and Therapies Open access
Hendy Kristyanto, Nienke J. Blomberg, Linda M. Slot, Ellen I. H. van der Voort, Priscilla F. Kerkman, Aleida M. Bakker, +8 more
117citations -
Multifunctional, Multivalent PIC Polymer Scaffolds for Targeting Antigen-Specific, Autoreactive B Cells2022 ACS Biomaterials Science & Engineering article Chemistry Advanced Polymer Synthesis and Characterization Open access
Hendy Kristyanto, Miles D. Holborough-Kerkvliet, Lianne P. W. M. Lelieveldt, Yvonne L Bartels, Roel Hammink, Karin Anna van Schie, +3 more
11citations -
Autoreactive B cells remain active despite clinical disease control in rheumatoid arthritis2024 Journal of Autoimmunity article Medicine Rheumatoid Arthritis Research and Therapies Open access
Sam Neppelenbroek, Nienke J. Blomberg, Arieke S. B. Kampstra, Joost G.K. van der Hem, Tom W. J. Huizinga, René E. M. Toes, +1 more
10citations -
Human islet T cells are highly reactive to preproinsulin in type 1 diabetes2021 Proceedings of the National Academy of Sciences article Biochemistry, Genetics and Molecular Biology Diabetes and associated disorders Open access cited by 1 patent
Amanda M. Anderson, Laurie G. Landry, Aimon K. Alkanani, Laura L. Pyle, Alvin C. Powers, Mark A. Atkinson, +4 more
96citations -
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation2022 Science Advances article Biochemistry, Genetics and Molecular Biology Glycosylation and Glycoproteins Research Open access
Theresa Kissel, Changrong Ge, Lise Hafkenscheid, Joanneke C. Kwekkeboom, Linda M. Slot, Marco Cavallari, +18 more
77citations -
Effect of Antigen Valency on Autoreactive B-Cell Targeting2023 Molecular Pharmaceutics article Medicine Rheumatoid Arthritis Research and Therapies Open access
Margot J. van Weijsten, Kevin R. Venrooij, Lianne P. W. M. Lelieveldt, Theresa Kissel, Erik van Buijtenen, Floris J. van Dalen, +3 more
4citations -
Autoreactive B cell responses targeting nuclear antigens in systemic sclerosis: Implications for disease pathogenesis2022 Seminars in Arthritis and Rheumatism article Medicine Systemic Sclerosis and Related Diseases Open access cited by 2 patents
Sophie I E Liem, Sam Neppelenbroek, Cynthia M. Fehres, Corrie M. Wortel, René E. M. Toes, Tom W. J. Huizinga, +2 more
16citations