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Simulation-based assessment of the P-glycoprotein expression-activity relationship shows a drug and system dependency2026 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Daan W. van Valkengoed, Vivi Rottschäfer, Elizabeth C. M. de Lange
1citations -
Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?2025 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Daan W. van Valkengoed, Makoto Hirasawa, Vivi Rottschäfer, Elizabeth C. M. de Lange
4citations -
Measurement of cyclosporin induced changes in P-glycoprotein function at the human blood-brain barrier using [18F]MC225 and PET2025 European Journal of Nuclear Medicine and Molecular Imaging article Medicine Drug Transport and Resistance Mechanisms Open access
Pascalle Mossel, Giordana Salvi de Souza, Antoon T. M. Willemsen, Gilles N. Stormezand, Nicola Antonio Colabufo, Jun Toyohara, +5 more
5citations -
Mapping cardiac drug transport: In vitro assessment of cardiac P-glycoprotein function with [18F]MC225 by using µ-engineered heart tissues2025 European Heart Journal Open article Medicine Drug Transport and Resistance Mechanisms Open access
Wanling Liu, Maureen Dannenberg, Pascalle Mossel, Zeyu Cai, Ines Farinha Antunes, Jürgen W. A. Sijbesma, +7 more
1citations -
Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?2025 Journal of Pharmacokinetics and Pharmacodynamics article Medicine Drug Transport and Resistance Mechanisms Open access
Berfin Gülave, Ariel Lesmana, Elizabeth C. M. de Lange, J. G. Coen van Hasselt
4citations -
Exploratory Study of Sex Differences in P‐Glycoprotein Function at the Blood–Brain Barrier2025 Clinical and Translational Science article Medicine Drug Transport and Resistance Mechanisms Open access
Giordana Salvi de Souza, Wanling Liu, Pascalle Mossel, Joost F. Somsen, Anna L. Bartels, Cristiane Regina Guerino Furini, +3 more
7citations -
Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4 , P‐gp, and CYP2D6 drug–drug–gene interaction network2023 CPT Pharmacometrics & Systems Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Denise Feick, Simeon Rüdesheim, Fatima Zahra Marok, Dominik Selzer, Helena Leonie Hanae Loer, Donato Teutonico, +6 more
12citations -
A New ABCB1 Inhibitor Enhances the Anticancer Effect of Doxorubicin in Both In Vitro and In Vivo Models of NSCLC2023 International Journal of Molecular Sciences article Medicine Drug Transport and Resistance Mechanisms Open access
Maria Pia Adorni, Maricla Galetti, Silvia La Monica, Matteo Incerti, Alessandro Ruffoni, Lisa Elviri, +6 more
16citations -
ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Drug Transport and Resistance Mechanisms Open access
Cecilia Bergonzini, Alessandro Gregori, Tessa M. S. Hagens, Vera E. van der Noord, Bob van de Water, Annelien J.M. Zweemer, +9 more
1citations -
Risperidone plasma concentrations are associated with side effects and effectiveness in children and adolescents with autism spectrum disorder2020 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Sanne Maartje Kloosterboer, Brenda C. M. de Winter, Catrien G. Reichart, Mirjam E. J. Kouijzer, Matthias M. J. de Kroon, Emma van Daalen, +11 more
80citations -
DDRE-32. ABC TRANSPORTERS RESTRICT THE BRAIN PENETRATION AND INTRACRANIAL EFFICACY OF ANTICANCER AGENTS EVEN WHEN BLOOD-BRAIN BARRIER INTEGRITY IS LOST2020 Neuro-Oncology conference-abstract Medicine Drug Transport and Resistance Mechanisms Open access
Mark C. de Gooijer, Elles Marleen Kemper, Levi C.M. Buil, Ceren H. Çitirikkaya, Tessa Buckle, Jos H. Beijnen, +1 more
0citations -
Organized Tubular Scaffolds to Build Vascularized Kidney Proximal Tubules2024 Journal of the American Society of Nephrology article Materials Science Electrospun Nanofibers in Biomedical Applications
Anne Metje van Genderen, Sebastian Beusink, Thibault Sampon, Marta G. Valverde, Tina Vermonden, Jitske Jansen, +2 more
0citations -
Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain2022 European Journal of Medicinal Chemistry article Medicine Cannabis and Cannabinoid Research Open access
Yingfang He, Uwe Grether, Marco F. Taddio, Carla Meier, Claudia Keller, Martin R. Edelmann, +14 more
14citations -
Towards precision dosing of aripiprazole in children and adolescents with autism spectrum disorder: Linking blood levels to weight gain and effectiveness2023 British Journal of Clinical Pharmacology article Medicine Pharmaceutical studies and practices Open access
Rebecca A. Hermans, Sebastiaan D. T. Sassen, Sanne Maartje Kloosterboer, Catrien G. Reichart, Mirjam E. J. Kouijzer, Matthias M. J. de Kroon, +8 more
8citations -
Extrahepatic metabolism of ibrutinib2020 Investigational New Drugs article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Johannes J.M. Rood, Amer Jamalpoor, Stéphanie van Hoppe, Matthijs J. van Haren, Roeland E. Wasmann, Manoe Jacoba Janssen, +4 more
28citations -
Nephroscreen: A robust and versatile renal tubule-on-a-chip platform for nephrotoxicity assessment2021 Current Opinion in Toxicology review Engineering 3D Printing in Biomedical Research Open access
Jelle Vriend, Marianne K. Vormann, Henriëtte L. Lanz, Jos Joore, Sebastiaan J. Trietsch, Frans G. M. Rüssel, +8 more
14citations -
Prevalence of ABCB1 3435C>T polymorphism in the Cuban population2021 Drug Metabolism and Personalized Therapy article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism
Idania Rodeiro, J. Herrera, Elizabeth Cuétara, Gabino Garrido, Elizabeth Reyes Reyes, Ioanna Martínez, +6 more
2citations -
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance2023 Proceedings of the National Academy of Sciences article Medicine Tuberculosis Research and Epidemiology Open access
M. Alexandra Lake, Kristin N. Adams, Feilin Nie, Elaine Fowler, Amit Kumar Verma, Silvia Dei, +6 more
33citations -
Should we abandon therapeutic drug monitoring of tacrolimus in whole blood and move to intracellular concentration measurements?2023 British Journal of Clinical Pharmacology article Medicine Renal Transplantation Outcomes and Treatments Open access
Suwasin Udomkarnjananun, Thanee Eiamsitrakoon, Brenda C. M. de Winter, Teun van Gelder, Dennis Alexander Hesselink
19citations -
A Comprehensive CYP2D6 Drug–Drug–Gene Interaction Network for Application in Precision Dosing and Drug Development2025 Clinical Pharmacology & Therapeutics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Simeon Rüdesheim, Helena Leonie Hanae Loer, Denise Feick, Fatima Zahra Marok, Laura Maria Fuhr, Dominik Selzer, +9 more
15citations -
Evaluation of Antiviral Drugs’ Central Nervous System Distribution Using In Vitro Blood–Brain and Blood-CSF Barrier Models: The Impact of Serum Protein Concentration2026 Cellular and Molecular Neurobiology article Neuroscience Barrier Structure and Function Studies Open access
Malik Johid Reza, Ukamaka O. Modebelu, Courtney Vail Fletcher, Nagadenahalli Byrareddy Siddappa, Robbyn Kimberly Anand, Tianyi Zhang, +6 more
0citations