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Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage and regeneration response after cisplatin2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Chemotherapy-induced organ toxicity mitigation Open access
Lukas S. Wijaya, Steven J. Kunnen, Panuwat Trairatphisan, Ciaran P. Fisher, Meredith E. Crosby, Kai Schaefer, +11 more
0citations -
Chemo-phosphoproteomic profiling with ATR inhibitors berzosertib and gartisertib uncovers new biomarkers and DNA damage response regulators2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Rathan S Jadav, Florian Weiland, Sylvie M. Noordermeer, Thomas D. Carroll, Yuandi Gao, Jianming Wang, +12 more
1citations -
UBC9 and EME1 sumoylation foster ribosomal DNA damage repair in CPT response2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Easa Nagamalleswari, Bakshi Karishma, Jan Breucker, Michaela Gschweitl, Román González‐Prieto, Nathalie Eisenhardt, +4 more
0citations -
CIP2A interacts with TopBP1 and is selectively essential for DNA damage-induced basal-like breast cancer tumorigenesis2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Anni Laine, Srikar Goud Nagelli, Caroline C. Farrington, Umar Butt, Anna N. Cvrljevic, Julia P. Vainonen, +17 more
2citations -
Clearance of DNA damage-arrested RNAPII is selectively impaired in Cockayne syndrome cells2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Paula J. van der Meer, George Yakoub, Yuka Nakazawa, Tomoo Ogi, Martijn S. Luijsterburg
8citations -
A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Diana van den Heuvel, Cornelia G. Spruijt, Román González‐Prieto, Michelle T. Paulsen, Di Zhou, Haoyu Wu, +10 more
5citations -
Transcriptomic mapping of the inter-individual variability of cellular stress response activation in primary human hepatocytes2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Marije Niemeijer, Witold Więcek, Suzanna Huppelschoten, Peter Bouwman, Audrey Baze, Celine Parmentier, +4 more
3citations -
DNA damage independent inhibition of NF-κB transcription by anthracyclines2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology NF-κB Signaling Pathways Open access
Ângelo Ferreira Chora, Dora C. S. Pedroso, Eleni Kyriakou, Nadja Pejanovic, Henrique G. Colaço, Raffaella Gozzelino, +20 more
2citations -
DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Tuberculosis Research and Epidemiology Open access
Melissa Dalcina Chengalroyen, Mandy K. Mason, Alessandro Borsellini, R. Tassoni, Garth L. Abrahams, Sasha L. Lynch, +10 more
2citations -
ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access cited by 1 patent
Yana van der Weegen, Klaas de Lint, Diana van den Heuvel, Yuka Nakazawa, Ishwarya Venkata Narayanan, Noud H.M. Klaassen, +8 more
6citations -
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access
Max S. Kloet, Chatrin Chatrin, Rishov Mukhopadhyay, Bianca D. M. van Tol, Rebecca Smith, Sarah A. Rotman, +7 more
2citations -
Keep looking at the negative side: improved detection of drug-induced liver injury with non-hepatotoxicant data oversampling2025 ChemRxiv preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Olivier J. M. Béquignon, Steven Wink, Steven W. Hiemstra, J. E. Fokkelman-Klip, Wouter den Hollander, Giulia Callegaro, +2 more
0citations -
Keep looking at the negative side: improved detection of drug-induced liver injury with non-hepatotoxicant data oversampling2025 ChemRxiv preprint Pharmacology, Toxicology and Pharmaceutics Drug-Induced Hepatotoxicity and Protection Open access
Olivier J. M. Béquignon, Steven Wink, Steven W. Hiemstra, J. E. Fokkelman-Klip, Wouter den Hollander, Giulia Callegaro, +2 more
0citations -
EZH2 Inhibition Sensitizes BRCA1-Deficient Breast Cancer to Synthetic Lethal Therapy with ATM Inhibitors2021 Research Square preprint Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Leonie Ratz, Chiara Svetlana Brambillasca, Leandra Bartke, Marieke van de Ven, Natalie Proost, Bjørn Siteur, +12 more
0citations -
Transcriptomic signatures associated with regional cortical thickness changes in Parkinson’s disease2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Parkinson's Disease Mechanisms and Treatments Open access
Arlin Keo, Oleh Dzyubachyk, Jeroen van der Grond, Jacobus Johannes van Hilten, Marcel J. T. Reinders, Ahmed Essam Mahfouz
0citations -
The mycobacterial mutasome: composition and recruitment in live cells2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Tuberculosis Research and Epidemiology Open access
Sophia J. Gessner, Zela Alexandria-Mae Martin, Joana A. Santos, Neeraj Dhar, Ryan Dinkele, Timothy J. de Wet, +12 more
4citations -
A missense variant effect map for the human tumour suppressor protein CHK22024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology BRCA gene mutations in cancer Open access
Marinella Gebbia, Daniel Zimmerman, Rosanna Jiang, Jochen Weile, Roujia Li, Michelle Gavac, +9 more
1citations -
Multi-level monitoring of EME1-MUS81 in CPT induced nucleolar rDNA repair2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Bakshi Karishma, Easa Nagamalleswari, Jan Breucker, Nathalie Eisenhardt, Richa Tiwari, Román González‐Prieto, +8 more
0citations -
Sequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndrome2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Congenital heart defects research Open access
Markus Krane, Martina Dreßen, Gianluca Santamaria, Ilaria My, Christine M. Schneider, Tatjana Dorn, +40 more
2citations -
LKB1 functions as a checkpoint for neuronal–glial balance during enteric nervous system development2026 Genes & Development preprint Medicine Congenital gastrointestinal and neural anomalies Open access
Anthony Lucas, Florence Appaix, Jordan Allard, Marie Mével‐Aliset, Florence Fauvelle, Bertrand Favier, +7 more
0citations