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Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data2021 Science Translational Medicine article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Maaike van der Lee, William G. Allard, Rolf H. A. M. Vossen, Renée F. Baak-Pablo, Roberta Menafra, Birgit A. L. M. Deiman, +8 more
80citations -
CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System—Results From the ADRED Study2021 Frontiers in Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Katja Susanne Just, Harald Dormann, Mathias Freitag, Marlen Schurig, Miriam Böhme, Michael Steffens, +5 more
20citations -
A Comprehensive CYP2D6 Drug–Drug–Gene Interaction Network for Application in Precision Dosing and Drug Development2025 Clinical Pharmacology & Therapeutics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Simeon Rüdesheim, Helena Leonie Hanae Loer, Denise Feick, Fatima Zahra Marok, Laura Maria Fuhr, Dominik Selzer, +9 more
15citations -
Cognitive function in the context of pharmacogenetic CYP2D6 variability and anticholinergic burden in older adults – results from the ActiFE study2026 European Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Linda Lorenz, Judith Berres, Michael Dieter Denkinger, Dietrich Rothenbacher, Stefanie Braig, Dhayana Dallmeier, +1 more
1citations -
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP3A4 and CYP1A2 and antipsychotics2023 European Journal of Human Genetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Lianne Beunk, Marga Nijenhuis, Bianca Soree, Nienke J. de Boer‐Veger, Anne‐Marie Buunk, Henk‐Jan Guchelaar, +9 more
154citations -
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone)2021 European Journal of Human Genetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Maja Matić, Marga Nijenhuis, Bianca Soree, Nienke J. de Boer‐Veger, Anne‐Marie Buunk, Elisa J. F. Houwink, +8 more
59citations -
The role of the poor metabolizer genotype CYP2D6 and CYP1A2 phenotype in the pharmacokinetics of duloxetine and venlafaxine—A case report2020 Basic & Clinical Pharmacology & Toxicology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism
Isabel Scharrer, Daniele Nolan, Markus R. Baumgartner, Michael Paulzen, Georgios Schoretsanitis, Franziskos Xepapadakos
6citations -
Nutrimetric Validation of Solanidine as Dietary‐Derived CYP2D6 Activity Marker In Vivo2023 Clinical Pharmacology & Therapeutics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Julian Peter Müller, Jens Andreas Sarömba, Patrick Ziegler, Roman Tremmel, Jens Rengelshausen, Elke Schaeffeler, +4 more
15citations -
Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account2025 Clinical Pharmacology & Therapeutics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Inger Johansson, Emmanouella M. Xanthopoulou, Yitian Zhou, Anabel Sanchez‐Spitman, Maaike van der Lee, Birgit Malene Wollmann, +6 more
8citations -
Combined effect of CYP2C19 and CYP2D6 genotypes on escitalopram serum concentration and its metabolic ratio in a European patient population2024 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Pari Faraj, Tore Haslemo, Jenny Phung Tran, Julia Stingl, Espen Molden, Kristine Hole
7citations -
Solanidine metabolic ratios for CYP2D6 phenotyping after a standardized potato meal2026 Frontiers in Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Julian Peter Müller, Daniel Friske, Mohammed Hasoumi, Bob Miller, Jens Andreas Sarömba, Jolanta Tupiec, +5 more
0citations -
Solanidine‐derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients2025 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Jens Andreas Sarömba, Julian Peter Müller, Jolanta Tupiec, Anjali A. Roeth, Berkan Kurt, Florian Kahles, +4 more
16citations -
Solanidine‐derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients2025 British Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Jens Andreas Sarömba, Julian Peter Müller, Jolanta Tupiec, Anjali A. Roeth, Berkan Kurt, Florian Kahles, +4 more
4citations -
CYP2D6 Metabolizer Phenotype Is Associated with Early Antidepressant Discontinuation in the UK Biobank2026 Pharmaceuticals article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Tehila Cohen, Estee Rebibo, Allan Hunter Young, Kristian Kleine Schaars, Mário F. Juruena, Thomas G. Schulze, +3 more
0citations -
Effects of genetic variability of CYP2D6 on neural substrates of sustained attention during on-task activity2020 Translational Psychiatry article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Roberto Viviani, Irene Messina, Lisa Dommes, Anna Paul, Katharina Luise Schneider, Catharina Scholl, +1 more
14citations -
Response to “Comment on cognitive function in the context of pharmacogenetic CYP2D6 variability and anticholinergic burden in older adults – results from the ActiFE study”2026 European Journal of Clinical Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Linda Lorenz, Judith Berres, Michael Dieter Denkinger, Dietrich Rothenbacher, Stefanie Braig, Dhayana Dallmeier, +1 more
0citations -
Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4 , P‐gp, and CYP2D6 drug–drug–gene interaction network2023 CPT Pharmacometrics & Systems Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Denise Feick, Simeon Rüdesheim, Fatima Zahra Marok, Dominik Selzer, Helena Leonie Hanae Loer, Donato Teutonico, +6 more
12citations -
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs2021 European Journal of Human Genetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
J. Brouwer, Marga Nijenhuis, Bianca Soree, Henk‐Jan Guchelaar, Jesse Joachim Swen, Ron H. N. van Schaik, +9 more
135citations -
Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction of CYP2D6 and COMT with atomoxetine and methylphenidate2022 European Journal of Human Genetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Marga Nijenhuis, Bianca Soree, Wafa O. M. Jama, Nienke J. de Boer‐Veger, Anne Marie Buunk, Henk‐Jan Guchelaar, +9 more
27citations -
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP2C19 and non-SSRI/non-TCA antidepressants2024 European Journal of Human Genetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Lianne Beunk, Marga Nijenhuis, Bianca Soree, Nienke J. de Boer‐Veger, Anne‐Marie Buunk, Henk‐Jan Guchelaar, +8 more
24citations -
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between CYP2D6 and CYP2C19 and tricyclic antidepressants2026 European Journal of Human Genetics article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Kristian Kleine Schaars, Marga Nijenhuis, Bianca Soree, Nienke J. de Boer‐Veger, Anne‐Marie Buunk, Henk‐Jan Guchelaar, +8 more
8citations -
Evaluation of stabilizing additives to protect activities of cytochrome P450 enzymes for in vitro drug testing and pharmacogenetic studies: Focus on CYP2D62025 Biochimica et Biophysica Acta (BBA) - General Subjects article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism
Sabrina Yamoune, Henner Koch, Daniel Delev, Yvonne G. Weber, Julia Stingl
4citations -
Very strong correlations of metoprolol- and solanidine-derived metabolic ratios in a real-world cohort with a stable metoprolol drug regimen2026 Frontiers in Pharmacology article Pharmacology, Toxicology and Pharmaceutics Pharmacogenetics and Drug Metabolism Open access
Jens Andreas Sarömba, Berkan Kurt, Alessandra Antwerpen, Konstantin Rex, Anna Giacin, Justus Bornemann, +12 more
1citations