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Fast and efficient generation of knock-in human organoids using homology-independent CRISPR/Cas9 precision genome editing2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access cited by 15 patents
Benedetta Artegiani, Delilah F. G. Hendriks, Joep Beumer, Rutger N.U. Kok, Xuan Zheng, Indi P. Joore, +4 more
29citations -
Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine CAR-T cell therapy research Open access cited by 6 patents
Yannick D. Müller, Leonardo M. R. Ferreira, Émilie Ronin, Patrick Ho, Vinh Q. Nguyen, Gaetano Faleo, +10 more
11citations -
PAKC: A novel Panel of HLA class I Antigen presentation machinery Knockout Cells from the same genetic origin2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Immunotherapy and Immune Responses Open access
Antonius A. de Waard, Tamara Verkerk, Marlieke L.M. Jongsma, Kelly Hoefakker, Sunesh Sethumadhavan, Carolin Gerke, +9 more
6citations -
Multi-Pathway DNA Double-Strand Break Repair Reporters Reveal Extensive Cross-Talk Between End-Joining, Single Strand Annealing, and Homologous Recombination2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Bert van de Kooij, Alex Kruswick, Haico van Attikum, Michael B. Yaffe
1citations -
T cell correction pipeline for Inborn Errors of Immunity2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Katariina Mamia, Solrun Kolbeinsdottir, Zhuokun Li, Kornel Labun, Anna Zofia Komisarczuk, Salla Keskitalo, +22 more
1citations -
The pain target NaV1.7 is expressed late during human iPS cell differentiation into sensory neurons as determined in high resolution imaging2023 Research Square preprint Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access
Yi Liu, Rachna Balaji, Marcelo A. S. Toledo, Sabrina Ernst, Petra A. I. Hautvast, Martin Zenke, +2 more
0citations -
Finding needles in haystacks: identification of novel conserved PETase enzymes in Streptomyces2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Enzyme Production and Characterization Open access
Jo-Anne Verschoor, Martijn R. J. Croese, Sven E. Lakemeier, Annemiek Mugge, Charlotte M. C. Burgers, Paolo Innocenti, +5 more
0citations -
Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Parasites and Host Interactions Open access
Benjamin J. Hulme, Kathrin K. Geyer, Josephine E. Forde-Thomas, Gilda Padalino, Dylan Wyn Phillips, Wannaporn Ittiprasert, +6 more
0citations -
Cell-Surface RNA Forms Ternary Complex with RNA-Binding Proteins and Heparan Sulfate to Recruit Immune Receptors2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology RNA Research and Splicing Open access
Zeshi Li, Bhagyashree S. Joshi, Ruud H. M. Wijdeven, Irene Santos‐Barriopedro, Milad Shademan, Eric Bos, +5 more
4citations -
MUSICiAn: Genome-wide Identification of Genes Involved in DNA Repair via Control-Free Mutational Spectra Analysis2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology DNA Repair Mechanisms Open access
Colm Seale, Marco Barazas, Robin van Schendel, Marcel Tijsterman, Joana P. Gonçalves
3citations -
A high-impact COL6A3 mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loading2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Osteoarthritis Treatment and Mechanisms Open access
Niek G.C. Bloks, Zainab Harissa, Shaunak Sanjay Adkar, Amanda R. Dicks, Ghazaleh Hajmousa, Nancy S. Steward, +8 more
2citations -
Accurate characterization of CRISPR-Cas9 genome editing outcomes and mosaicism with near-perfect long reads2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Ida Höijer, Robin van Schendel, Anastasia Emmanouilidou, Rebecka Östlund, Ignas Bunikis, Marcel Tijsterman, +2 more
1citations -
The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Ananth Pallaseni, Elin Madli Peets, Gareth Girling, Ivan Kuzmin, Marilin Moor, Núria Muñoz-Subirana, +7 more
1citations -
Modulating CRISPR-Cas genome editing using guide-complementary DNA oligonucleotides2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Thomas Swartjes, Peng Shang, Dennis J. van den Berg, Tim Künne, Niels Geijsen, Stan J. J. Brouns, +3 more
0citations -
GSTM1 and GSTT1 Double Null Genotypes Determining Cell Fate and Proliferation as Potential Risk Factors of Relapse in Children With Hematological Malignancies After Stem Cell Transplantation. On Behalf of the Pediatric Disease Working Party of the European Society for Blood and Marrow Transplantation2021 Research Square preprint Biochemistry, Genetics and Molecular Biology Glutathione Transferases and Polymorphisms Open access
Simona Jurković Mlakar, Chakradhara Rao S. Uppugunduri, Tiago Nava, Vid Mlakar, Hadrien G. Golay, Shannon K. D. Robin, +10 more
0citations -
Alpha-mannosidase-2 modulates arbovirus infection in a pathogen- and Wolbachia -specific manner in Aedes aegypti mosquitoes2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Agricultural and Biological Sciences Insect symbiosis and bacterial influences Open access
Nadya Urakova, Renuka Elizabeth Joseph, Allyn Huntsinger, Vanessa M. Macias, Matthew J. Jones, Leah T. Sigle, +7 more
0citations -
CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology CRISPR and Genetic Engineering Open access
Ida Höijer, Anastasia Emmanouilidou, Rebecka Östlund, Robin van Schendel, Selma Bozorgpana, Lars Feuk, +3 more
0citations -
Lignin degradation and valorization by Pseudomonas putida KT2440: a new role for glutathione peroxidase2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Engineering Lignin and Wood Chemistry Open access
Qing Zhou, Annabel Fransen, Paolo Innocenti, Arthur F. J. Ram, Johannes H. DE WINDE
0citations -
A genome-wide CRISPR/Cas phenotypic screen for modulators of DUX4 cytotoxicity reveals screen complications2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Muscle Physiology and Disorders Open access
Ator Ashoti, Francesco Limone, Melissa van Kranenburg, Anna Alemany, Mirna Lilian Baak, Judith Vivié, +4 more
2citations -
A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology interferon and immune responses Open access
Sandra Hess, Marta Campos Alonso, Michael J. D. Brand, Susan Lauw, Urs Lindenmann, Paul P. Geurink, +3 more
6citations -
Roles for the long non-coding RNA Pax6os1 / PAX6-AS1 in pancreatic beta cell identity and function2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Pancreatic function and diabetes Open access
Livia López–Noriega, Rebecca Callingham, Aida Martínez-Sánchez, Sameena Nawaz, Grazia Pizza, Nejc Haberman, +13 more
6citations -
YAP1 is essential for self-organized differentiation of pluripotent stem cells2022 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Pluripotent Stem Cells Research Open access
Kira Zeevaert, Roman Goetzke, Mohamed H. Elsafi Mabrouk, Catharina Maaßen, Ann-Christine Henneke, Chao He, +3 more
1citations