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The TNFα-binding domain of the therapeutic antibody adalimumab elicits CD4 T-cell responses in rheumatoid arthritis patients2025 Frontiers in Immunology article Biochemistry, Genetics and Molecular Biology vaccines and immunoinformatics approaches Open access
Mateusz Makuch, Josine van Beek, Carla Ann Wijbrandts, Marja Aalbers, Philippe Stas, Alexander B. Meijer, +7 more
3citations -
CD4+ T-Cell Responses Mediate Progressive Neurodegeneration in Experimental Ischemic Retinopathy2020 American Journal Of Pathology article Medicine Glaucoma and retinal disorders Open access cited by 1 patent
T. H. Khanh Vu, Huihui Chen, Li Pan, Kin‐Sang Cho, Djoeke Doesburg, Eric F. Thee, +4 more
34citations -
Defining nature, responses and drivers of regulatory- and conventional CD4+ T cells in the human term decidua2026 Frontiers in Immunology article Immunology and Microbiology Reproductive System and Pregnancy Open access
Lotte J. Verleng, Julia Busselaar, Mark Mensink, Ellen Schrama, Hanneke Kapsenberg, Carin van der Keur, +5 more
0citations -
CD4+ T-cell help delivery to monocyte-derived dendritic cells promotes effector differentiation of helper and cytotoxic T cells2025 Immunology Letters article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Douwe M. T. Bosma, Julia Busselaar, Mo D. Staal, Elselien Frijlink, Matthias Mack, Fiamma Salerno, +1 more
7citations -
Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens2023 Nature Biotechnology article Medicine Cancer Immunotherapy and Biomarkers Open access cited by 2 patents
Chiara Maria Cattaneo, Thomas Battaglia, Jos H. M. Urbanus, Živa Moravec, Rhianne Voogd, Rosa de Groot, +5 more
43citations -
High-affinity antigen association to cationic liposomes via coiled coil-forming peptides induces a strong antigen-specific CD4+ T-cell response2020 European Journal of Pharmaceutics and Biopharmaceutics article Immunology and Microbiology Immunotherapy and Immune Responses Open access cited by 2 patents
R.J.T. Leboux, Naomi Benne, Winant L. van Os, Jeroen Bussmann, Alexander Kros, Wim Jiskoot, +1 more
11citations -
Characterization of T cell responses to co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in healthy adults in Gabon2021 PLoS neglected tropical diseases article Immunology and Microbiology Parasites and Host Interactions Open access
Yoanne D. Mouwenda, Madeleine Eunice Betouke Ongwe, Friederike Sonnet, Koen A. Stam, Lucja A. Labuda, Sophie De Vries, +14 more
13citations -
T cell responses in repeated controlled human schistosome infection compared to natural exposure2025 Nature Communications article Immunology and Microbiology Parasites and Host Interactions Open access
Emmanuella Driciru, Jan Pieter R. Koopman, Sabine C.L. van Steenbergen, Friederike Sonnet, Koen A. Stam, Laura de Bes-Roeleveld, +17 more
7citations -
CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors2024 Cellular and Molecular Immunology article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Xin Lei, Daniël de Groot, Marij J.P. Welters, Tom de Wit, Ellen Schrama, Hans van Eenennaam, +10 more
65citations -
T-cell responses to primary SARS-CoV-2 vaccination in Down syndrome – From childhood to adulthood2026 Human Vaccines & Immunotherapeutics article Medicine SARS-CoV-2 and COVID-19 Research Open access
Lobke C.M. Hensen, Bianca M. M. Streng, Femke van Wijk, Stefan Nierkens, Joanne Wildenbeest, Louis Bont, +16 more
0citations -
A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs2024 Nature Communications article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Kieran English, Rain Y. Q. Kwan, Lauren E. Holz, Claire McGuffog, Jelte M. M. Krol, Daryan Kempe, +7 more
26citations -
Efficient generation of human cDC1-like cells to detect and enhance tumor-reactive T cells via CD4+ T cell help2026 Cell Reports Methods article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Yizhi Wang, Xin Lei, Tom de Wit, Ellen Schrama, Marij J.P. Welters, Karel van Leeuwen, +8 more
0citations -
Stem-like PD-1 + TCF-1 + CD8 + T cells result from helpless priming and rely on CD4 + T-cell help to complete their cytotoxic effector differentiation2026 Journal for ImmunoTherapy of Cancer article Immunology and Microbiology T-cell and B-cell Immunology Open access
Julia Busselaar, Douwe M. T. Bosma, Mo D. Staal, Xin Lei, Yanling Xiao, Jannie G. Borst
2citations -
Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy2026 Proceedings of the National Academy of Sciences article Medicine Parkinson's Disease Mechanisms and Treatments Open access
Jae‐Seung Moon, Salvinaz Islam Moutusy, Mengrui Zhang, Alain Ndayisaba, Diego Rodriguez, Daniel N. El Kodsi, +12 more
1citations -
Type 2 T-Cell Responses against Distinct Epitopes of the Desmoglein 3 Ectodomain in Pemphigus Vulgaris2023 Journal of Investigative Dermatology article Medicine Autoimmune Bullous Skin Diseases Open access
Dario Didona, Luca Scarsella, Christoph Hudemann, Karolin Volkmann, Christine Lea Zimmer, Benedikt Beckert, +20 more
15citations -
Pediatric IBD patients show medication and disease activity dependent changes in NK cell and CD4 memory T cell populations2023 Frontiers in Pediatrics article Biochemistry, Genetics and Molecular Biology Inflammatory Bowel Disease Open access
Angeliki Pappa, Julia Mührer, Sudheendra Hebbar Subramanyam, Kim Ohl, Moritz Muschaweck, Norbert Wagner, +2 more
6citations -
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2 specific CD8 T cell responses following COVID-192021 Zenodo (CERN European Organization for Nuclear Research) article Medicine SARS-CoV-2 and COVID-19 Research Open access
Anna H.E. Roukens, Cilia R. Pothast, Marion Koning, Wesley Huisman, Renate S. Hagedoorn, Mihaela Zlei, +10 more
2citations