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Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation2024 Cell Communication and Signaling article Biochemistry, Genetics and Molecular Biology Bone Metabolism and Diseases Open access
Aaron Babendreyer, Julia Kieselhorst, Cindy Rinkens, A. M. Lyashenko, Stefan Düsterhöft, Holger Jahr, +2 more
10citations -
Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells2020 Frontiers in Cardiovascular Medicine article Biochemistry, Genetics and Molecular Biology Protease and Inhibitor Mechanisms Open access
Aaron Babendreyer, Diana M. Rojas‐González, Anja Adelina Giese, Sandra Fellendorf, Stefan Düsterhöft, Petra Mela, +1 more
27citations -
In Silico and Experimental ADAM17 Kinetic Modeling as Basis for Future Screening System for Modulators2022 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Protease and Inhibitor Mechanisms Open access cited by 1 patent
Marian Bienstein, Dmitriy Minond, Ulrich Schwaneberg, Mehdi D. Davari, Daniela Yildiz
13citations -
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release2021 Cellular and Molecular Life Sciences article Biochemistry, Genetics and Molecular Biology Protease and Inhibitor Mechanisms Open access
Stefan Düsterhöft, Selcan Kahveci-Türköz, Justyna Wozniak, Anke Seifert, Petr Kašpárek, Henrike Ohm, +8 more
25citations -
ADAM17 Is an Essential Factor for the Infection of Bovine Cells with Pestiviruses2022 Viruses article Agricultural and Biological Sciences Animal Virus Infections Studies Open access
Marianne Zaruba, Hann-Wei Chen, Ole Frithjof Pietsch, Kati Szakmary-Braendle, Angelika Auer, Marlene Mötz, +5 more
15citations -
Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity2024 Cellular and Molecular Life Sciences article Biochemistry, Genetics and Molecular Biology Protease and Inhibitor Mechanisms Open access
Katharina Bläsius, Sarah Knapp, Charlotte Flaßhove, Friederike Sonnabend, Diandra T. Keller, Nikola Tacken, +8 more
12citations -
A structural model of the iRhom–ADAM17 sheddase complex reveals functional insights into its trafficking and activity2023 Cellular and Molecular Life Sciences article Biochemistry, Genetics and Molecular Biology Protease and Inhibitor Mechanisms Open access
Selcan Kahveci-Türköz, Katharina Bläsius, Justyna Wozniak, Cindy Rinkens, Anke Seifert, Petr Kašpárek, +9 more
18citations -
ADAM10 and ADAM17 differently mediate induced pulmonary ACE release by either direct proteolysis or indirect upregulation protein synthesis2026 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research article Medicine Renin-Angiotensin System Studies Open access
Yan Yu, Aaron Babendreyer, Alessa Pabst, Anna Michely, Marie Tauscher, Christian Martin, +4 more
3citations -
ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?2023 International Journal of Molecular Sciences article Biochemistry, Genetics and Molecular Biology Protease and Inhibitor Mechanisms Open access
Sanne Lidewij Maas, Marjo M. P. C. Donners, Emiel P. C. van der Vorst
16citations -
EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells2023 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research article Medicine Cytokine Signaling Pathways and Interactions Open access
Neele Schumacher, Ilka Thomsen, Florian Brundert, Václav Hejret, Stefan Düsterhöft, Boris Tichý, +3 more
15citations -
Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells2021 Scientific Reports article Biochemistry, Genetics and Molecular Biology Protease and Inhibitor Mechanisms Open access cited by 1 patent
Anja Adelina Giese, Aaron Babendreyer, Peter Krappen, Annika Groß, Pavel Strnad, Stefan Düsterhöft, +1 more
21citations -
The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner2020 International Journal of Molecular Sciences article Immunology and Microbiology Phagocytosis and Immune Regulation Open access
Anke Seifert, Justyna Wozniak, Stefan Düsterhöft, Petr Kašpárek, Radislav Sedláček, Stephan Dreschers, +3 more
13citations -
Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells2020 British Journal of Cancer article Biochemistry, Genetics and Molecular Biology Enzyme function and inhibition Open access
Ivana Kajanová, Miriam Zaťovičová, Lenka Jelenska, Olga Sedlakova, Monika Baráthová, Lucia Csáderová, +11 more
22citations -
Shedding of Klotho: Functional Implications in Chronic Kidney Disease and Associated Vascular Disease2021 Frontiers in Cardiovascular Medicine article Medicine Parathyroid Disorders and Treatments Open access cited by 1 patent
Valeria Saar-Kovrov, Marjo M. P. C. Donners, Emiel P. C. van der Vorst
45citations