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Oral iptacopan monotherapy in paroxysmal nocturnal haemoglobinuria: final 48-week results from the open-label, randomised, phase 3 APPLY-PNH trial in anti-C5-treated patients and the open-label, single-arm, phase 3 APPOINT-PNH trial in patients previously untreated with complement inhibitors2025 The Lancet Haematology article Immunology and Microbiology Complement system in diseases Open access
Antonio Maria Risitano, Austin Gladston Kulasekararaj, Phillip Scheinberg, Alexander Röth, Bing Han, Jaroslaw Pawel Maciejewski, +47 more
15citations -
The role of complement activation in autoimmune liver disease2020 Autoimmunity Reviews article Medicine Liver Diseases and Immunity Open access cited by 1 patent
Maaike Biewenga, Arantza Fariña Sarasqueta, Maarten E. Tushuizen, Eveline S. M. de Jonge‐Muller, Bart van Hoek, Leendert Adrianus Trouw
35citations -
Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Immunology and Microbiology Biomarkers in Disease Mechanisms Open access cited by 2 patents
Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers, Mariska E. Keizer, Jip Wulffelé, Tijn T. van der Velden, +4 more
3citations -
Complement Activation Levels Are Related to Disease Stage in AMD2020 Investigative Ophthalmology & Visual Science article Medicine Retinal Diseases and Treatments Open access cited by 1 patent
Thomas J. Heesterbeek, Yara T. E. Lechanteur, Laura Lorés‐Motta, Tina Schick, Mohamed R. Daha, Lebriz Altay, +6 more
79citations -
Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein2024 Proceedings of the National Academy of Sciences article Immunology and Microbiology Biomarkers in Disease Mechanisms Open access cited by 2 patents
Dylan P. Noone, Marjolein M. E. Isendoorn, Sebastiaan M. W. R. Hamers, Mariska E. Keizer, Jip Wulffelé, Tijn T. van der Velden, +4 more
26citations -
P774: SUBSTANTIAL INCREASES IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) RED BLOOD CELL CLONE SIZE WITH ORAL IPTACOPAN MONOTHERAPY CONFIRMS CONTROL OF HEMOLYSIS IN COMPLEMENT INHIBITOR-NAÏVE PNH PATIENTS
Régis Peffault de Latour, Bing Han, Jaroslaw Pawel Maciejewski, Yutaka Ueda, Rong Fu, Li Zhang, +15 more
3citations -
Development of an in vitro system and model-based translational framework to assess haemolysis risk following intravenous abuse of medications containing polyethylene oxide2020 Toxicology in Vitro article Immunology and Microbiology Complement system in diseases Open access
Peter Persich, Gerwin Erik Engels, Willem van Oeveren, Eric Galia, Stephan Benay, Susanne Thun
5citations -
MDS-278 Substantial Increases in Paroxysmal Nocturnal Hemoglobinuria (PNH) Red Blood Cell Clone Size With Oral Iptacopan Monotherapy Confirms Control of Hemolysis in Complement Inhibitor-Naive PNH Patients2023 Clinical Lymphoma Myeloma & Leukemia conference-abstract Immunology and Microbiology Complement system in diseases Open access
Régis Peffault de Latour, Bing Han, Jaroslaw Pawel Maciejewski, Yasutaka Ueda, Rong Fu, Li Zhang, +15 more
1citations -
Reply to the correspondence on ‘Development of bispecific antibodies that allow targeted local complement inhibition on rheumatoid arthritis related antigens’2026 Annals of the Rheumatic Diseases letter Immunology and Microbiology Complement system in diseases
Haiyu Wang, Saskia Nugteren, Rick J. Groenland, Stef van der Meulen, Hanneke Kapsenberg, Christoph Gstöttner, +6 more
0citations -
Cryo-Electron Microscopy and Biochemical Analysis Offer Insights Into the Effects of Acidic pH, Such as Occur During Acidosis, on the Complement Binding Properties of C-Reactive Protein19citations
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The INCLUSIVE System: A General Framework for Adaptive Industrial Automation2020 IEEE Transactions on Automation Science and Engineering article Psychology Human-Automation Interaction and Safety Open access cited by 1 patent
Valeria Villani, Lorenzo Sabattini, Paulina Barańska, Enrico Callegati, Julia N. Czerniak, Adel Debbache, +14 more
31citations -
Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody2023 Frontiers in Cellular Neuroscience article Neuroscience Neuroinflammation and Neurodegeneration Mechanisms Open access
Florine Seidel, Kees Fluiter, Robert Kleemann, Nicole Worms, Anita van Nieuwkoop, Martien P. M. Caspers, +5 more
3citations -
Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation2023 Proceedings of the National Academy of Sciences article Medicine Systemic Lupus Erythematosus Research Open access cited by 3 patents
Douwe J. Dijkstra, Fleur S. van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn, Jos Pool, Cynthia S. M. Kramer, +10 more
18citations